brca1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description breast cancer 1, early onset|This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 672)
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Genes

255 genes co-occuring with the biological term brca1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACACA acetyl-CoA carboxylase alpha
AHR aryl hydrocarbon receptor
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
AR androgen receptor
AREG amphiregulin
ARNT aryl hydrocarbon receptor nuclear translocator
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
AURKA aurora kinase A
BABAM1 BRISC and BRCA1 A complex member 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BARD1 BRCA1 associated RING domain 1
BCL2 B-cell CLL/lymphoma 2
BP1 Blood pressure QTL 1
BRAP BRCA1 associated protein
BRAT1 BRCA1-associated ATM activator 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRD7 bromodomain containing 7
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CA9 carbonic anhydrase IX
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR2 cell cycle and apoptosis regulator 2
CCND1 cyclin D1
CCNE1 cyclin E1
CCNT1 cyclin T1
CD82 CD82 molecule
CDC25A cell division cycle 25A
CDC27 cell division cycle 27
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CHD8 chromodomain helicase DNA binding protein 8
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSPN claspin
CREBBP CREB binding protein
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTSL cathepsin L
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAZAP1 DAZ associated protein 1
DDB2 damage-specific DNA binding protein 2, 48kDa
DDIT3 DNA-damage-inducible transcript 3
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DTX3L deltex 3 like, E3 ubiquitin ligase
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F6 E2F transcription factor 6
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EGLN1 egl-9 family hypoxia-inducible factor 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EGR1 early growth response 1
EIF3E eukaryotic translation initiation factor 3, subunit E
ELAVL1 ELAV like RNA binding protein 1
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ERCC4 excision repair cross-complementation group 4
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
ESR1 estrogen receptor 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM175A family with sequence similarity 175, member A
FANCD2 Fanconi anemia, complementation group D2
FASN fatty acid synthase
FBXO44 F-box protein 44
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FGFR2 fibroblast growth factor receptor 2
FHIT fragile histidine triad
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FLNA filamin A, alpha
FOXA1 forkhead box A1
FOXC1 forkhead box C1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA3 GATA binding protein 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
H2AFX H2A histone family, member X
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOXA5 homeobox A5
HOXA9 homeobox A9
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTRA1 HtrA serine peptidase 1
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IRF7 interferon regulatory factor 7
IRS1 insulin receptor substrate 1
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
JUNB jun B proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KL klotho
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT18 keratin 18, type I
LMO4 LIM domain only 4
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MBD2 methyl-CpG binding domain protein 2
MCPH1 microcephalin 1
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MGMT O-6-methylguanine-DNA methyltransferase
MIR146A microRNA 146a
MIR146B microRNA 146b
MIR182 microRNA 182
MIR342 microRNA 342
MIR638 microRNA 638
MKI67 marker of proliferation Ki-67
MLH1 mutL homolog 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH2 mutS homolog 2
MTA1 metastasis associated 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOD1 myogenic differentiation 1
NBN nibrin
NBR1 neighbor of BRCA1 gene 1
NCOA3 nuclear receptor coactivator 3
NELFB negative elongation factor complex member B
NF1 neurofibromin 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFYA nuclear transcription factor Y, alpha
NINL ninein-like
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMI N-myc (and STAT) interactor
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NUCLEOLIN nucleolin multifunctional protein
NUMB numb homolog (Drosophila)
OLA1 Obg-like ATPase 1
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PARP9 poly (ADP-ribose) polymerase family, member 9
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PGR progesterone receptor
PHB prohibitin
PHBP3 prohibitin pseudogene 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK1 polo-like kinase 1
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
POU2F1 POU class 2 homeobox 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PTEN phosphatase and tensin homolog
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTK2 protein tyrosine kinase 2
RAD21 RAD21 homolog (S. pombe)
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RAD51C RAD51 paralog C
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC1 replication factor C (activator 1) 1, 145kDa
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF4 ring finger protein 4
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPA2 replication protein A2, 32kDa
RPS6 ribosomal protein S6
RPSA ribosomal protein SA
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SET SET nuclear proto-oncogene
SLX4 SLX4 structure-specific endonuclease subunit
SMAD3 SMAD family member 3
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC1A structural maintenance of chromosomes 1A
SNAI2 snail family zinc finger 2
SP1 Sp1 transcription factor
SPP1 secreted phosphoprotein 1
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAT1 signal transducer and activator of transcription 1, 91kDa
TERT telomerase reverse transcriptase
TGFB1 transforming growth factor, beta 1
TLK1 tousled-like kinase 1
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TRAF2 TNF receptor-associated factor 2
TSG101 tumor susceptibility 101
TUBB3 tubulin, beta 3 class III
TUBG1 tubulin, gamma 1
UBE2I ubiquitin-conjugating enzyme E2I
UBXN1 UBX domain protein 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
VAV1 vav 1 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
VIM vimentin
WHSC1 Wolf-Hirschhorn syndrome candidate 1
XIST X inactive specific transcript (non-protein coding)
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YARS tyrosyl-tRNA synthetase
YY1 YY1 transcription factor
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZNF350 zinc finger protein 350
ZNF365 zinc finger protein 365