brca1 Gene Set

Dataset Phosphosite Textmining Biological Term Annotations
Category structural or functional annotations
Type biological term
Description breast cancer 1, early onset|This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 672)
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Genes

47 proteins co-occuring with the biological term brca1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Symbol Name
ACACA acetyl-CoA carboxylase alpha
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
ATRIP ATR interacting protein
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CFL1 cofilin 1 (non-muscle)
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ESR1 estrogen receptor 1
H2AFX H2A histone family, member X
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIST1H3A histone cluster 1, H3a
HORMAD1 HORMA domain containing 1
HORMAD2 HORMA domain containing 2
JUN jun proto-oncogene
LIMK2 LIM domain kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MCM2 minichromosome maintenance complex component 2
MDC1 mediator of DNA-damage checkpoint 1
MLH1 mutL homolog 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
NBN nibrin
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PGR progesterone receptor
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RAD17 RAD17 homolog (S. pombe)
RAD52 RAD52 homolog (S. cerevisiae)
RAD9A RAD9 homolog A (S. pombe)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBBP8 retinoblastoma binding protein 8
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPA2 replication protein A2, 32kDa
RPS6 ribosomal protein S6
SMC1A structural maintenance of chromosomes 1A
STAT1 signal transducer and activator of transcription 1, 91kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
UIMC1 ubiquitin interaction motif containing 1
WRN Werner syndrome, RecQ helicase-like