brca2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description breast cancer 2, early onset|Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008] (NCBI Entrez Gene Database, 675)
Similar Terms
Downloads & Tools

Genes

108 genes co-occuring with the biological term brca2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BARD1 BRCA1 associated RING domain 1
BCCIP BRCA2 and CDKN1A interacting protein
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRD7 bromodomain containing 7
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C11ORF30 chromosome 11 open reading frame 30
CASP10 caspase 10, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CDH13 cadherin 13
CDK2 cyclin-dependent kinase 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CREBBP CREB binding protein
CTBP1 C-terminal binding protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DMC1 DNA meiotic recombinase 1
DUSP12 dual specificity phosphatase 12
E2F3 E2F transcription factor 3
ERCC2 excision repair cross-complementation group 2
ERCC4 excision repair cross-complementation group 4
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FAM175A family with sequence similarity 175, member A
FANCA Fanconi anemia, complementation group A
FANCD2 Fanconi anemia, complementation group D2
FANCG Fanconi anemia, complementation group G
FGFR2 fibroblast growth factor receptor 2
FLNA filamin A, alpha
GATA3 GATA binding protein 3
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HDAC1 histone deacetylase 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMG20B high mobility group 20B
HTRA1 HtrA serine peptidase 1
IGF2 insulin-like growth factor 2
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KL klotho
KRAS Kirsten rat sarcoma viral oncogene homolog
LATS1 large tumor suppressor kinase 1
LSP1 lymphocyte-specific protein 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MCPH1 microcephalin 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEN1 multiple endocrine neoplasia I
MIR1245A microRNA 1245a
MIR146A microRNA 146a
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MORF4L1 mortality factor 4 like 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MSH6 mutS homolog 6
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PALB2 partner and localizer of BRCA2
PARP1 poly (ADP-ribose) polymerase 1
PAX5 paired box 5
PAX6 paired box 6
PCAT1 prostate cancer associated transcript 1 (non-protein coding)
PDCD6IP programmed cell death 6 interacting protein
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLK1 polo-like kinase 1
POLH polymerase (DNA directed), eta
RAD21 RAD21 homolog (S. pombe)
RAD51 RAD51 recombinase
RAD51B RAD51 paralog B
RAD51C RAD51 paralog C
RAD52 RAD52 homolog (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBMX RNA binding motif protein, X-linked
RECQL5 RecQ protein-like 5
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SHFM1 split hand/foot malformation (ectrodactyly) type 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLX4 SLX4 structure-specific endonuclease subunit
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SP1 Sp1 transcription factor
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TGFB1 transforming growth factor, beta 1
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TP53 tumor protein p53
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UIMC1 ubiquitin interaction motif containing 1
USP11 ubiquitin specific peptidase 11
WT1 Wilms tumor 1
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZAR1L zygote arrest 1-like
ZNF350 zinc finger protein 350
ZNF365 zinc finger protein 365