bromocriptine-1925 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the bromocriptine-1925 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADA adenosine deaminase
AKR1C2 aldo-keto reductase family 1, member C2
AKTIP AKT interacting protein
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
BEX1 brain expressed, X-linked 1
CABIN1 calcineurin binding protein 1
CCDC130 coiled-coil domain containing 130
CCDC85C coiled-coil domain containing 85C
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CHKA choline kinase alpha
COBL cordon-bleu WH2 repeat protein
COL5A1 collagen, type V, alpha 1
COPS7B COP9 signalosome subunit 7B
DCBLD2 discoidin, CUB and LCCL domain containing 2
DLK2 delta-like 2 homolog (Drosophila)
DTX4 deltex 4, E3 ubiquitin ligase
DUSP3 dual specificity phosphatase 3
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EPHB3 EPH receptor B3
EPS8L1 EPS8-like 1
FBXO42 F-box protein 42
FNBP1 formin binding protein 1
GBX2 gastrulation brain homeobox 2
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GPR4 G protein-coupled receptor 4
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRK6 G protein-coupled receptor kinase 6
GSTZ1 glutathione S-transferase zeta 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
HABP4 hyaluronan binding protein 4
HEATR6 HEAT repeat containing 6
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HIST1H2BG histone cluster 1, H2bg
HMOX2 heme oxygenase 2
HP1BP3 heterochromatin protein 1, binding protein 3
INSIG1 insulin induced gene 1
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLF12 Kruppel-like factor 12
KRT86 keratin 86, type II
LBP lipopolysaccharide binding protein
LDLR low density lipoprotein receptor
LPCAT4 lysophosphatidylcholine acyltransferase 4
LPIN1 lipin 1
LPP LIM domain containing preferred translocation partner in lipoma
MFSD11 major facilitator superfamily domain containing 11
MICALL1 MICAL-like 1
MMP25 matrix metallopeptidase 25
MVK mevalonate kinase
N4BP1 NEDD4 binding protein 1
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NIPAL2 NIPA-like domain containing 2
P2RX6 purinergic receptor P2X, ligand gated ion channel, 6
PCGF2 polycomb group ring finger 2
PCSK7 proprotein convertase subtilisin/kexin type 7
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PLSCR3 phospholipid scramblase 3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRDX2 peroxiredoxin 2
RGS3 regulator of G-protein signaling 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNF43 ring finger protein 43
RPL10 ribosomal protein L10
RPL27A ribosomal protein L27a
SAMHD1 SAM domain and HD domain 1
SHMT1 serine hydroxymethyltransferase 1 (soluble)
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAPC2 small nuclear RNA activating complex, polypeptide 2, 45kDa
SQLE squalene epoxidase
SRBD1 S1 RNA binding domain 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSBP3 single stranded DNA binding protein 3
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
STK19 serine/threonine kinase 19
STX12 syntaxin 12
SURF2 surfeit 2
SYNGR1 synaptogyrin 1
TBCD tubulin folding cofactor D
TEAD3 TEA domain family member 3
TFG TRK-fused gene
TMEM161A transmembrane protein 161A
TP53I11 tumor protein p53 inducible protein 11
TSPAN9 tetraspanin 9
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WRAP53 WD repeat containing, antisense to TP53
WSCD1 WSC domain containing 1
YIPF2 Yip1 domain family, member 2
ZNF337 zinc finger protein 337
ZSCAN26 zinc finger and SCAN domain containing 26

decreased expression

Symbol Name
ABI1 abl-interactor 1
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACSF2 acyl-CoA synthetase family member 2
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIDA axin interactor, dorsalization associated
ANXA2P3 annexin A2 pseudogene 3
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ASCC1 activating signal cointegrator 1 complex subunit 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BCL2A1 BCL2-related protein A1
BFAR bifunctional apoptosis regulator
BMS1 BMS1 ribosome biogenesis factor
C1ORF109 chromosome 1 open reading frame 109
CD53 CD53 molecule
CDC73 cell division cycle 73
CHPF chondroitin polymerizing factor
CNTD2 cyclin N-terminal domain containing 2
COMMD10 COMM domain containing 10
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CTSC cathepsin C
CXCL6 chemokine (C-X-C motif) ligand 6
DCTN4 dynactin 4 (p62)
DMXL1 Dmx-like 1
DPYD dihydropyrimidine dehydrogenase
ECT2 epithelial cell transforming 2
EIF1B eukaryotic translation initiation factor 1B
EMC2 ER membrane protein complex subunit 2
FAM8A1 family with sequence similarity 8, member A1
FPGT fucose-1-phosphate guanylyltransferase
FZD6 frizzled class receptor 6
GSTM5 glutathione S-transferase mu 5
HACD3 3-hydroxyacyl-CoA dehydratase 3
HAS2 hyaluronan synthase 2
HSPA4L heat shock 70kDa protein 4-like
IFT57 intraflagellar transport 57
ISCU iron-sulfur cluster assembly enzyme
KATNBL1 katanin p80 subunit B-like 1
KCTD3 potassium channel tetramerization domain containing 3
KIF20B kinesin family member 20B
KIF3B kinesin family member 3B
LTN1 listerin E3 ubiquitin protein ligase 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGT1 magnesium transporter 1
MBD5 methyl-CpG binding domain protein 5
MEAF6 MYST/Esa1-associated factor 6
MEX3C mex-3 RNA binding family member C
MOCS2 molybdenum cofactor synthesis 2
MORC3 MORC family CW-type zinc finger 3
MSX1 msh homeobox 1
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEIL3 nei endonuclease VIII-like 3 (E. coli)
NEMF nuclear export mediator factor
NFS1 NFS1 cysteine desulfurase
NIP7 NIP7, nucleolar pre-rRNA processing protein
NOL6 nucleolar protein 6 (RNA-associated)
NRSN2 neurensin 2
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
NUCB2 nucleobindin 2
NUPL2 nucleoporin like 2
PAK1IP1 PAK1 interacting protein 1
PARG poly (ADP-ribose) glycohydrolase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit
POTEKP POTE ankyrin domain family, member K, pseudogene
PRCC papillary renal cell carcinoma (translocation-associated)
RBBP5 retinoblastoma binding protein 5
RNF11 ring finger protein 11
RNF167 ring finger protein 167
RPL23AP32 ribosomal protein L23a pseudogene 32
RPS17P5 ribosomal protein S17 pseudogene 5
SDHAF3 succinate dehydrogenase complex assembly factor 3
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SIRT7 sirtuin 7
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLMO2 slowmo homolog 2 (Drosophila)
SNAI2 snail family zinc finger 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
TGIF1 TGFB-induced factor homeobox 1
THYN1 thymocyte nuclear protein 1
TMEM242 transmembrane protein 242
TRIP12 thyroid hormone receptor interactor 12
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
TUBA3D tubulin, alpha 3d
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae)
UBA2 ubiquitin-like modifier activating enzyme 2
UBXN2B UBX domain protein 2B
USP8 ubiquitin specific peptidase 8
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial
ZBTB11 zinc finger and BTB domain containing 11
ZNF217 zinc finger protein 217