bronchiectasis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (Human Disease Ontology, DOID_9563)
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Genes

150 genes co-occuring with the disease bronchiectasis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
FLNC filamin C, gamma 2.5839
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.80923
AGFG2 ArfGAP with FG repeats 2 1.6877
ELANE elastase, neutrophil expressed 1.52292
DNAI1 dynein, axonemal, intermediate chain 1 1.41271
CD79A CD79a molecule, immunoglobulin-associated alpha 1.30314
DNAH11 dynein, axonemal, heavy chain 11 1.23646
CXCL8 chemokine (C-X-C motif) ligand 8 1.21478
CD4 CD4 molecule 1.0816
DNAH5 dynein, axonemal, heavy chain 5 0.982215
AK7 adenylate kinase 7 0.965825
MPO myeloperoxidase 0.95745
ALB albumin 0.936629
BPI bactericidal/permeability-increasing protein 0.915551
CRP C-reactive protein, pentraxin-related 0.879014
DYNLRB2 dynein, light chain, roadblock-type 2 0.832329
BTK Bruton agammaglobulinemia tyrosine kinase 0.800333
DNAH1 dynein, axonemal, heavy chain 1 0.783526
DNALI1 dynein, axonemal, light intermediate chain 1 0.779023
SPAG17 sperm associated antigen 17 0.778613
CTSG cathepsin G 0.77575
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 0.766759
RSPH9 radial spoke head 9 homolog (Chlamydomonas) 0.76431
TEF thyrotrophic embryonic factor 0.763902
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.746798
OR2H2 olfactory receptor, family 2, subfamily H, member 2 0.734622
PTBP3 polypyrimidine tract binding protein 3 0.728547
CAPS calcyphosine 0.725311
CCDC40 coiled-coil domain containing 40 0.703134
MUC1 mucin 1, cell surface associated 0.694301
MMP8 matrix metallopeptidase 8 0.687491
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.680697
SFTPA2 surfactant protein A2 0.677504
GC group-specific component (vitamin D binding protein) 0.667947
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6 0.663578
DNAH9 dynein, axonemal, heavy chain 9 0.658818
CCDC39 coiled-coil domain containing 39 0.653671
REG3G regenerating islet-derived 3 gamma 0.647743
SPEF2 sperm flagellar 2 0.641827
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.637102
NCF4 neutrophil cytosolic factor 4, 40kDa 0.630027
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 0.629242
SPAG16 sperm associated antigen 16 0.61162
RIN2 Ras and Rab interactor 2 0.61162
LYZ lysozyme 0.588222
KPNB1 karyopherin (importin) beta 1 0.581606
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.561004
KCNRG potassium channel regulator 0.560616
DNAI2 dynein, axonemal, intermediate chain 2 0.544705
SLPI secretory leukocyte peptidase inhibitor 0.541992
IL31RA interleukin 31 receptor A 0.538118
FAT3 FAT atypical cadherin 3 0.533088
HSF4 heat shock transcription factor 4 0.518805
SPAG6 sperm associated antigen 6 0.516494
DNASE1 deoxyribonuclease I 0.506123
TLR2 toll-like receptor 2 0.505356
TNPO1 transportin 1 0.505356
MMP9 matrix metallopeptidase 9 0.498467
TLR5 toll-like receptor 5 0.488169
CST4 cystatin S 0.485505
SFTPD surfactant protein D 0.476772
RGMA repulsive guidance molecule family member a 0.464283
SIAE sialic acid acetylesterase 0.456732
PRAMEF12 PRAME family member 12 0.45447
CXCR1 chemokine (C-X-C motif) receptor 1 0.446558
BEST2 bestrophin 2 0.437906
PGRMC1 progesterone receptor membrane component 1 0.433021
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 0.428516
USB1 U6 snRNA biogenesis 1 0.427765
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.422515
AES amino-terminal enhancer of split 0.422515
HGS hepatocyte growth factor-regulated tyrosine kinase substrate 0.421016
TNF tumor necrosis factor 0.415773
RNASE3 ribonuclease, RNase A family, 3 0.409414
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 0.404931
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.401572
CDAN1 codanin 1 0.400453
CD40LG CD40 ligand 0.379626
ICK intestinal cell (MAK-like) kinase 0.368518
SCGB3A1 secretoglobin, family 3A, member 1 0.367779
TTR transthyretin 0.357814
FOXJ1 forkhead box J1 0.350452
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.342372
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.342006
GRP gastrin-releasing peptide 0.342006
CDON cell adhesion associated, oncogene regulated 0.336144
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.333949
PDZD11 PDZ domain containing 11 0.331025
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 0.328834
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 0.328469
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 0.325916
SAA2 serum amyloid A2 0.322273
OR10K2 olfactory receptor, family 10, subfamily K, member 2 0.320454
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.319363
RPGR retinitis pigmentosa GTPase regulator 0.314278
HLA-A major histocompatibility complex, class I, A 0.307033
CHRM1 cholinergic receptor, muscarinic 1 0.305226
HAND2 heart and neural crest derivatives expressed 2 0.303059
PKD2 polycystic kidney disease 2 (autosomal dominant) 0.303059
SFTPC surfactant protein C 0.300533
IFT88 intraflagellar transport 88 0.298731
IL6 interleukin 6 0.297291
CAMP cathelicidin antimicrobial peptide 0.285444
IL1B interleukin 1, beta 0.283297
CORO1A coronin, actin binding protein, 1A 0.281153
IL4R interleukin 4 receptor 0.280439
TYK2 tyrosine kinase 2 0.279724
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 0.278297
SAA1 serum amyloid A1 0.277227
BLVRA biliverdin reductase A 0.277227
PKD1 polycystic kidney disease 1 (autosomal dominant) 0.27687
OFD1 oral-facial-digital syndrome 1 0.272953
CD27 CD27 molecule 0.272953
MST1 macrophage stimulating 1 0.268687
TIMP1 TIMP metallopeptidase inhibitor 1 0.257711
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.256299
HLA-C major histocompatibility complex, class I, C 0.253127
CTCFL CCCTC-binding factor (zinc finger protein)-like 0.249608
GARS glycyl-tRNA synthetase 0.244345
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.238403
HBA2 hemoglobin, alpha 2 0.232142
HTRA3 HtrA serine peptidase 3 0.224884
OR4F29 olfactory receptor, family 4, subfamily F, member 29 0.223165
CD19 CD19 molecule 0.217012
DOCK8 dedicator of cytokinesis 8 0.216672
SH2D1A SH2 domain containing 1A 0.204593
TUB tubby bipartite transcription factor 0.202946
PPCS phosphopantothenoylcysteine synthetase 0.202618
CSTA cystatin A (stefin A) 0.199681
MMP1 matrix metallopeptidase 1 0.199356
FCGRT Fc fragment of IgG, receptor, transporter, alpha 0.198709
STAT4 signal transducer and activator of transcription 4 0.198064
CALCA calcitonin-related polypeptide alpha 0.194232
SDC1 syndecan 1 0.193285
LTA4H leukotriene A4 hydrolase 0.189859
BLOC1S6 biogenesis of lysosomal organelles complex-1, subunit 6, pallidin 0.187415
RING1 ring finger protein 1 0.187113
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.18651
FBLN5 fibulin 5 0.18621
GNS glucosamine (N-acetyl)-6-sulfatase 0.185313
S100A8 S100 calcium binding protein A8 0.181798
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 0.177301
CTSB cathepsin B 0.170789
TOB1 transducer of ERBB2, 1 0.170544
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit 0.169571
CFI complement factor I 0.164786
ICAM1 intercellular adhesion molecule 1 0.163729
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) 0.161139
PIGR polymeric immunoglobulin receptor 0.158434
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 0.158266