bronchiectasis Gene Set

Dataset	GeneRIF Biological Term Annotations
Category	structural or functional annotations
Type	biological term
Description	A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (Human Disease Ontology, DOID_9563)
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Genes

17 genes co-occuring with the biological term bronchiectasis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol	Name
ADRB2	adrenoceptor beta 2, surface
CFTR	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CXCR1	chemokine (C-X-C motif) receptor 1
ELANE	elastase, neutrophil expressed
FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2
IFNG	interferon, gamma
JMJD6	jumonji domain containing 6
MBL2	mannose-binding lectin (protein C) 2, soluble
MMP1	matrix metallopeptidase 1
MMP8	matrix metallopeptidase 8
MMP9	matrix metallopeptidase 9
SCNN1B	sodium channel, non voltage gated 1 beta subunit
SCNN1G	sodium channel, non voltage gated 1 gamma subunit
SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TLR2	toll-like receptor 2