bronchiectasis Gene Set

Dataset MPO Gene-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (Human Disease Ontology, DOID_9563)
External Link http://www.informatics.jax.org/searches/Phat.cgi?id=MP:0011012
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Genes

1 gene mutations causing the bronchiectasis phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

Symbol Name
NPAS3 neuronal PAS domain protein 3