brugada syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. (Human Disease Ontology, DOID_0050451)
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Genes

97 genes co-occuring with the disease brugada syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SCN5A sodium channel, voltage gated, type V alpha subunit 4.19377
GPD1L glycerol-3-phosphate dehydrogenase 1-like 2.18712
SCN3B sodium channel, voltage gated, type III beta subunit 2.11
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 2.07899
RANGRF RAN guanine nucleotide release factor 1.97223
SCN1B sodium channel, voltage gated, type I beta subunit 1.78849
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.75323
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 1.74233
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.64936
SCN2B sodium channel, voltage gated, type II beta subunit 1.59519
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 1.54982
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.5282
SCN4B sodium channel, voltage gated, type IV beta subunit 1.46979
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 1.4632
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 1.41972
NOTCH1 notch 1 1.38996
ANK2 ankyrin 2, neuronal 1.37512
ST20 suppressor of tumorigenicity 20 1.37076
NAV1 neuron navigator 1 1.36814
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 1.36422
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 1.35028
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.33414
PKP2 plakophilin 2 1.33196
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.32541
RYR2 ryanodine receptor 2 (cardiac) 1.26473
SCN8A sodium channel, voltage gated, type VIII alpha subunit 1.25037
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 1.21305
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4 1.17765
SCN3A sodium channel, voltage gated, type III alpha subunit 1.17378
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 1.11687
PRSS30P protease, serine, 30, pseudogene 1.04546
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 1.01047
FGF11 fibroblast growth factor 11 0.938289
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.865093
DPP6 dipeptidyl-peptidase 6 0.837656
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 0.819206
TMEM43 transmembrane protein 43 0.813873
KCNIP2 Kv channel interacting protein 2 0.806898
SCN4A sodium channel, voltage gated, type IV alpha subunit 0.798282
IRX5 iroquois homeobox 5 0.781069
SCN10A sodium channel, voltage gated, type X alpha subunit 0.763494
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.761862
NAV2 neuron navigator 2 0.743547
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.739488
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 0.730571
CAV3 caveolin 3 0.727333
IRF6 interferon regulatory factor 6 0.726524
IRX4 iroquois homeobox 4 0.706754
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 0.705144
KCNT1 potassium channel, sodium activated subfamily T, member 1 0.699517
FGF12 fibroblast growth factor 12 0.681096
SLMAP sarcolemma associated protein 0.681096
VDAC3 voltage-dependent anion channel 3 0.671527
GSPT1 G1 to S phase transition 1 0.643404
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease 0.636708
IRX6 iroquois homeobox 6 0.612011
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 0.609276
IRX1 iroquois homeobox 1 0.609276
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.60303
JPH2 junctophilin 2 0.586276
FGF14 fibroblast growth factor 14 0.560227
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.556344
ANK1 ankyrin 1, erythrocytic 0.493885
CASQ2 calsequestrin 2 (cardiac muscle) 0.492359
TPTE transmembrane phosphatase with tensin homology 0.470332
HIST1H1A histone cluster 1, H1a 0.465038
JUP junction plakoglobin 0.451454
CANX calnexin 0.43753
PDZD2 PDZ domain containing 2 0.429266
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 0.42139
KCNJ11 potassium channel, inwardly rectifying subfamily J, member 11 0.372217
BSN bassoon presynaptic cytomatrix protein 0.367779
TBX2 T-box 2 0.349717
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.346409
DLG1 discs, large homolog 1 (Drosophila) 0.344574
DSG2 desmoglein 2 0.31464
DSC2 desmocollin 2 0.295851
PEG10 paternally expressed 10 0.279011
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 0.269043
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 0.269043
TBX3 T-box 3 0.26266
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.257358
TNNT2 troponin T type 2 (cardiac) 0.244696
RIPK4 receptor-interacting serine-threonine kinase 4 0.242945
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.242595
IGLV2-8 immunoglobulin lambda variable 2-8 0.238054
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 0.233878
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.221793
APLNR apelin receptor 0.205916
HTN3 histatin 3 0.205585
DSC3 desmocollin 3 0.205254
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 0.197099
MEGF6 multiple EGF-like-domains 6 0.185313
CLCN1 chloride channel, voltage-sensitive 1 0.185313
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.176757
MMD monocyte to macrophage differentiation-associated 0.172038
WARS tryptophanyl-tRNA synthetase 0.160203