btk Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description Bruton agammaglobulinemia tyrosine kinase|The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013] (NCBI Entrez Gene Database, 695)
Similar Terms
Downloads & Tools

Genes

21 genes co-occuring with the biological term btk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANKRD54 ankyrin repeat domain 54
BAG3 BCL2-associated athanogene 3
BCL2 B-cell CLL/lymphoma 2
BLNK B-cell linker
BTK Bruton agammaglobulinemia tyrosine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CD40 CD40 molecule, TNF receptor superfamily member 5
CREB1 cAMP responsive element binding protein 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
SYK spleen tyrosine kinase
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TLR9 toll-like receptor 9
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta