bupropion-3180 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the bupropion-3180 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ADCK2 aarF domain containing kinase 2
ADRA1A adrenoceptor alpha 1A
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANTXR1 anthrax toxin receptor 1
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APAF1 apoptotic peptidase activating factor 1
APBA3 amyloid beta (A4) precursor protein-binding, family A, member 3
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARPIN actin-related protein 2/3 complex inhibitor
ARTN artemin
BTN3A3 butyrophilin, subfamily 3, member A3
BUD31 BUD31 homolog (S. cerevisiae)
C17ORF53 chromosome 17 open reading frame 53
C1ORF21 chromosome 1 open reading frame 21
C1RL complement component 1, r subcomponent-like
CA5B carbonic anhydrase VB, mitochondrial
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CARTPT CART prepropeptide
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCDC30 coiled-coil domain containing 30
CD1A CD1a molecule
CD1B CD1b molecule
CD22 CD22 molecule
CD6 CD6 molecule
CDRT1 CMT1A duplicated region transcript 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN17 claudin 17
CLTA clathrin, light chain A
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CRYBA2 crystallin, beta A2
CTNNA2 catenin (cadherin-associated protein), alpha 2
DSC2 desmocollin 2
DTNA dystrobrevin, alpha
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EVI2B ecotropic viral integration site 2B
FBXL7 F-box and leucine-rich repeat protein 7
FGF12 fibroblast growth factor 12
FKBP10 FK506 binding protein 10, 65 kDa
FLJ11292
GH1 growth hormone 1
GLS glutaminase
GPR21 G protein-coupled receptor 21
GPR85 G protein-coupled receptor 85
GRM7 glutamate receptor, metabotropic 7
HDAC7 histone deacetylase 7
HFE hemochromatosis
HIST1H1T histone cluster 1, H1t
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IFI44 interferon-induced protein 44
IFNA8 interferon, alpha 8
IGKC immunoglobulin kappa constant
KIF25 kinesin family member 25
LARP7 La ribonucleoprotein domain family, member 7
MAOA monoamine oxidase A
MAP3K9 mitogen-activated protein kinase kinase kinase 9
MMP27 matrix metallopeptidase 27
MYRIP myosin VIIA and Rab interacting protein
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NPAP1 nuclear pore associated protein 1
NUDCD3 NudC domain containing 3
ODAM odontogenic, ameloblast asssociated
OR2B6 olfactory receptor, family 2, subfamily B, member 6
PCBP3 poly(rC) binding protein 3
PCDHGA1 protocadherin gamma subfamily A, 1
PDE4D phosphodiesterase 4D, cAMP-specific
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PNMA2 paraneoplastic Ma antigen 2
PRKCQ protein kinase C, theta
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RYR2 ryanodine receptor 2 (cardiac)
SECTM1 secreted and transmembrane 1
SETD1A SET domain containing 1A
SIRT5 sirtuin 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLITRK5 SLIT and NTRK-like family, member 5
SOX15 SRY (sex determining region Y)-box 15
SPAG6 sperm associated antigen 6
SPEF1 sperm flagellar 1
ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2
TAGLN3 transgelin 3
TECPR2 tectonin beta-propeller repeat containing 2
THY1 Thy-1 cell surface antigen
TK2 thymidine kinase 2, mitochondrial
TPSAB1 tryptase alpha/beta 1
TRPM3 transient receptor potential cation channel, subfamily M, member 3
TXK TXK tyrosine kinase
UBE2I ubiquitin-conjugating enzyme E2I
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
VGF VGF nerve growth factor inducible
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AFAP1 actin filament associated protein 1
AFF4 AF4/FMR2 family, member 4
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL15 ADP-ribosylation factor-like 15
ART1 ADP-ribosyltransferase 1
BAG4 BCL2-associated athanogene 4
BMP4 bone morphogenetic protein 4
C2ORF27A chromosome 2 open reading frame 27A
C2ORF68 chromosome 2 open reading frame 68
CAMKV CaM kinase-like vesicle-associated
CCDC85C coiled-coil domain containing 85C
CD82 CD82 molecule
CDKL3 cyclin-dependent kinase-like 3
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN5 chloride channel, voltage-sensitive 5
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CST6 cystatin E/M
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DGAT1 diacylglycerol O-acyltransferase 1
EFNA3 ephrin-A3
EPHA2 EPH receptor A2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EXD3 exonuclease 3'-5' domain containing 3
FAM131A family with sequence similarity 131, member A
FBXL6 F-box and leucine-rich repeat protein 6
FGGY FGGY carbohydrate kinase domain containing
FKBP5 FK506 binding protein 5
FLRT3 fibronectin leucine rich transmembrane protein 3
FURIN furin (paired basic amino acid cleaving enzyme)
GEMIN8 gem (nuclear organelle) associated protein 8
GMPR guanosine monophosphate reductase
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GPX1 glutathione peroxidase 1
HIST1H2AL histone cluster 1, H2al
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-J major histocompatibility complex, class I, J (pseudogene)
HOXC10 homeobox C10
HOXC5 homeobox C5
HOXC8 homeobox C8
IFT140 intraflagellar transport 140
JUNB jun B proto-oncogene
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA1456 KIAA1456
KRT83 keratin 83, type II
LDHB lactate dehydrogenase B
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYZ lysozyme
MAP1S microtubule-associated protein 1S
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAP9 microtubule-associated protein 9
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MRPL44 mitochondrial ribosomal protein L44
NBEAL2 neurobeachin-like 2
NPY5R neuropeptide Y receptor Y5
NSD1 nuclear receptor binding SET domain protein 1
NXPH4 neurexophilin 4
ONECUT2 one cut homeobox 2
PCDHA6 protocadherin alpha 6
PHF21A PHD finger protein 21A
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLL polymerase (DNA directed), lambda
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
PTPRG protein tyrosine phosphatase, receptor type, G
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RCAN3 RCAN family member 3
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RNF39 ring finger protein 39
ROM1 retinal outer segment membrane protein 1
RPL13P5 ribosomal protein L13 pseudogene 5
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A4 S100 calcium binding protein A4
SCMH1 sex comb on midleg homolog 1 (Drosophila)
SDC3 syndecan 3
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SKA1 spindle and kinetochore associated complex subunit 1
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SOX3 SRY (sex determining region Y)-box 3
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SRGN serglycin
STAG3L1 stromal antigen 3-like 1 (pseudogene)
TCP10 t-complex 10
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TMEM104 transmembrane protein 104
TMEM209 transmembrane protein 209
TOM1 target of myb1 (chicken)
TTC23 tetratricopeptide repeat domain 23
UBXN6 UBX domain protein 6
UNC119 unc-119 homolog (C. elegans)
VEGFB vascular endothelial growth factor B
VEZT vezatin, adherens junctions transmembrane protein
ZBTB6 zinc finger and BTB domain containing 6