bupropion-5782 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the bupropion-5782 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF2 AF4/FMR2 family, member 2
ALPK1 alpha-kinase 1
APC2 adenomatosis polyposis coli 2
AREG amphiregulin
ARTN artemin
BAAT bile acid CoA:amino acid N-acyltransferase
C16ORF70 chromosome 16 open reading frame 70
C8A complement component 8, alpha polypeptide
CA2 carbonic anhydrase II
CARTPT CART prepropeptide
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD3D CD3d molecule, delta (CD3-TCR complex)
CD40 CD40 molecule, TNF receptor superfamily member 5
CEL carboxyl ester lipase
CELF2 CUGBP, Elav-like family member 2
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CFAP70 cilia and flagella associated protein 70
CLDN10 claudin 10
CNTD2 cyclin N-terminal domain containing 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAAM2 dishevelled associated activator of morphogenesis 2
DENND3 DENN/MADD domain containing 3
DHRS12 dehydrogenase/reductase (SDR family) member 12
DOCK6 dedicator of cytokinesis 6
DOK2 docking protein 2, 56kDa
DUSP1 dual specificity phosphatase 1
EDN1 endothelin 1
EFR3B EFR3 homolog B (S. cerevisiae)
ELSPBP1 epididymal sperm binding protein 1
ESRRA estrogen-related receptor alpha
FAXDC2 fatty acid hydroxylase domain containing 2
FLT4 fms-related tyrosine kinase 4
GK glycerol kinase
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GYG2 glycogenin 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDAC6 histone deacetylase 6
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
IBSP integrin-binding sialoprotein
IGF1R insulin-like growth factor 1 receptor
IGHM immunoglobulin heavy constant mu
IHH indian hedgehog
IL1R1 interleukin 1 receptor, type I
IRGC immunity-related GTPase family, cinema
KCNK12 potassium channel, two pore domain subfamily K, member 12
KDM5C lysine (K)-specific demethylase 5C
KIAA1107 KIAA1107
KIF1A kinesin family member 1A
KLHDC8A kelch domain containing 8A
KYNU kynureninase
LAG3 lymphocyte-activation gene 3
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LINC00597 long intergenic non-protein coding RNA 597
LMTK2 lemur tyrosine kinase 2
LMX1B LIM homeobox transcription factor 1, beta
LRRC37BP1 leucine rich repeat containing 37B pseudogene 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAST2 microtubule associated serine/threonine kinase 2
MBL2 mannose-binding lectin (protein C) 2, soluble
MFAP3 microfibrillar-associated protein 3
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTMR3 myotubularin related protein 3
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow
N4BP1 NEDD4 binding protein 1
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NKX2-5 NK2 homeobox 5
NMT2 N-myristoyltransferase 2
NR5A2 nuclear receptor subfamily 5, group A, member 2
OR10H1 olfactory receptor, family 10, subfamily H, member 1
ORC5 origin recognition complex, subunit 5
PADI2 peptidyl arginine deiminase, type II
PGAP3 post-GPI attachment to proteins 3
PICK1 protein interacting with PRKCA 1
PIN1P1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 pseudogene 1
PLEKHM2 pleckstrin homology domain containing, family M (with RUN domain) member 2
PMCHL1 pro-melanin-concentrating hormone-like 1, pseudogene
PRB3 proline-rich protein BstNI subfamily 3
PRKG1 protein kinase, cGMP-dependent, type I
PTCH1 patched 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PVR poliovirus receptor
PVT1 Pvt1 oncogene (non-protein coding)
RANBP1 RAN binding protein 1
RPL10L ribosomal protein L10-like
RPL35A ribosomal protein L35a
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SLMO1 slowmo homolog 1 (Drosophila)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TBXA2R thromboxane A2 receptor
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLDC1 TBC/LysM-associated domain containing 1
TTC12 tetratricopeptide repeat domain 12
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
XIST X inactive specific transcript (non-protein coding)
ZNF528 zinc finger protein 528
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ARID3A AT rich interactive domain 3A (BRIGHT-like)
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BCAS3 breast carcinoma amplified sequence 3
C11ORF63 chromosome 11 open reading frame 63
C1QTNF1 C1q and tumor necrosis factor related protein 1
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C9ORF40 chromosome 9 open reading frame 40
C9ORF91 chromosome 9 open reading frame 91
CARD8 caspase recruitment domain family, member 8
CCDC71 coiled-coil domain containing 71
CDK3 cyclin-dependent kinase 3
CORO2A coronin, actin binding protein, 2A
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREB5 cAMP responsive element binding protein 5
CSRNP3 cysteine-serine-rich nuclear protein 3
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14
DOCK1 dedicator of cytokinesis 1
EFNA3 ephrin-A3
EGF epidermal growth factor
FANCF Fanconi anemia, complementation group F
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FAT4 FAT atypical cadherin 4
FBXL15 F-box and leucine-rich repeat protein 15
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FCHO1 FCH domain only 1
FGGY FGGY carbohydrate kinase domain containing
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
GLCE glucuronic acid epimerase
GLS2 glutaminase 2 (liver, mitochondrial)
GMEB1 glucocorticoid modulatory element binding protein 1
HIST1H2AI histone cluster 1, H2ai
HIST1H2AM histone cluster 1, H2am
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8
IFI44L interferon-induced protein 44-like
IFNAR1 interferon (alpha, beta and omega) receptor 1
IL17RA interleukin 17 receptor A
IL4R interleukin 4 receptor
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD7 potassium channel tetramerization domain containing 7
KIAA0895 KIAA0895
KLF2 Kruppel-like factor 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MAST3 microtubule associated serine/threonine kinase 3
MATN3 matrilin 3
MBTD1 mbt domain containing 1
MMRN2 multimerin 2
MON1B MON1 secretory trafficking family member B
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTA2 metastasis associated 1 family, member 2
MYLK myosin light chain kinase
NDE1 nudE neurodevelopment protein 1
NT5M 5',3'-nucleotidase, mitochondrial
PARM1 prostate androgen-regulated mucin-like protein 1
PCDHGB5 protocadherin gamma subfamily B, 5
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLD2 phospholipase D2
PRR15L proline rich 15-like
PRR4 proline rich 4 (lacrimal)
QSER1 glutamine and serine rich 1
R3HCC1L R3H domain and coiled-coil containing 1-like
RAD54L2 RAD54-like 2 (S. cerevisiae)
RNF31 ring finger protein 31
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
S100A3 S100 calcium binding protein A3
SAP30L SAP30-like
SCAMP4 secretory carrier membrane protein 4
SCARA3 scavenger receptor class A, member 3
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC35F6 solute carrier family 35, member F6
SLC46A3 solute carrier family 46, member 3
SMAD7 SMAD family member 7
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPAG4 sperm associated antigen 4
SPIDR scaffolding protein involved in DNA repair
SULT1A2 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
SYNPO synaptopodin
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box)
TEX40 testis expressed 40
TMEM159 transmembrane protein 159
TPST2 tyrosylprotein sulfotransferase 2
TRAF2 TNF receptor-associated factor 2
TRIM66 tripartite motif containing 66
TUBA3C tubulin, alpha 3c
UBOX5 U-box domain containing 5
UGT8 UDP glycosyltransferase 8
WDR4 WD repeat domain 4
XK X-linked Kx blood group
ZFHX3 zinc finger homeobox 3
ZNF215 zinc finger protein 215
ZNF324 zinc finger protein 324
ZNF671 zinc finger protein 671
ZNF767P zinc finger family member 767, pseudogene
ZNF862 zinc finger protein 862