buspirone-6743 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the buspirone-6743 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTN3 actinin, alpha 3 (gene/pseudogene)
ACVR1B activin A receptor, type IB
ADAM12 ADAM metallopeptidase domain 12
ADAM22 ADAM metallopeptidase domain 22
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide
ADPRH ADP-ribosylarginine hydrolase
AHCYL1 adenosylhomocysteinase-like 1
AIF1 allograft inflammatory factor 1
ARMC4 armadillo repeat containing 4
ATF5 activating transcription factor 5
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
BAAT bile acid CoA:amino acid N-acyltransferase
BBC3 BCL2 binding component 3
CD6 CD6 molecule
CD86 CD86 molecule
CD8B CD8b molecule
CLCN7 chloride channel, voltage-sensitive 7
COL21A1 collagen, type XXI, alpha 1
CTSZ cathepsin Z
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGCR8 DGCR8 microprocessor complex subunit
DHRS7 dehydrogenase/reductase (SDR family) member 7
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DPY19L1P1 DPY19L1 pseudogene 1
DSTYK dual serine/threonine and tyrosine protein kinase
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EHMT1 euchromatic histone-lysine N-methyltransferase 1
ELOVL2 ELOVL fatty acid elongase 2
ETV1 ets variant 1
ETV6 ets variant 6
EYA4 EYA transcriptional coactivator and phosphatase 4
FGB fibrinogen beta chain
FLJ21369 uncharacterized protein FLJ21369
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GJA8 gap junction protein, alpha 8, 50kDa
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR135 G protein-coupled receptor 135
GPR21 G protein-coupled receptor 21
HBS1L HBS1-like translational GTPase
HDAC6 histone deacetylase 6
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HIC2 hypermethylated in cancer 2
HIPK3 homeodomain interacting protein kinase 3
ING4 inhibitor of growth family, member 4
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
LAMC2 laminin, gamma 2
LIPG lipase, endothelial
MAP1B microtubule-associated protein 1B
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MARK2 MAP/microtubule affinity-regulating kinase 2
MON2 MON2 homolog (S. cerevisiae)
N4BP1 NEDD4 binding protein 1
NF1 neurofibromin 1
NNAT neuronatin
NPC1 Niemann-Pick disease, type C1
NYNRIN NYN domain and retroviral integrase containing
OGDHL oxoglutarate dehydrogenase-like
PEX5L peroxisomal biogenesis factor 5-like
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKNOX1 PBX/knotted 1 homeobox 1
PPIAL4A peptidylprolyl isomerase A (cyclophilin A)-like 4A
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRM1 protamine 1
PRO2964 uncharacterized protein PRO2964
PRR5 proline rich 5 (renal)
PRY PTPN13-like, Y-linked
PTAFR platelet-activating factor receptor
PVT1 Pvt1 oncogene (non-protein coding)
RDH8 retinol dehydrogenase 8 (all-trans)
REPS1 RALBP1 associated Eps domain containing 1
RHOT2 ras homolog family member T2
RPS3A ribosomal protein S3A
RUNX1 runt-related transcription factor 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SRSF7 serine/arginine-rich splicing factor 7
TAGLN3 transgelin 3
TBCD tubulin folding cofactor D
TCF12 transcription factor 12
THRB thyroid hormone receptor, beta
TMEM231 transmembrane protein 231
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNPO2 transportin 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCL vinculin
VDAC3 voltage-dependent anion channel 3
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae)
VWA5A von Willebrand factor A domain containing 5A
WSB1 WD repeat and SOCS box containing 1
YIPF4 Yip1 domain family, member 4
ZFP64 ZFP64 zinc finger protein
ZMIZ2 zinc finger, MIZ-type containing 2
ZNF506 zinc finger protein 506
ZNF609 zinc finger protein 609
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM2 ADAM metallopeptidase domain 2
AGMAT agmatine ureohydrolase (agmatinase)
AHDC1 AT hook, DNA binding motif, containing 1
ALPK1 alpha-kinase 1
APOC4 apolipoprotein C-IV
AURKC aurora kinase C
BATF3 basic leucine zipper transcription factor, ATF-like 3
BEX1 brain expressed, X-linked 1
BFSP1 beaded filament structural protein 1, filensin
C17ORF70 chromosome 17 open reading frame 70
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C22ORF29 chromosome 22 open reading frame 29
C22ORF46 chromosome 22 open reading frame 46
CALCOCO1 calcium binding and coiled-coil domain 1
CARTPT CART prepropeptide
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASS4 Cas scaffolding protein family member 4
CCDC85C coiled-coil domain containing 85C
CCDC88C coiled-coil domain containing 88C
CDH7 cadherin 7, type 2
CDT1 chromatin licensing and DNA replication factor 1
CENPO centromere protein O
CLEC2B C-type lectin domain family 2, member B
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CPZ carboxypeptidase Z
CRMP1 collapsin response mediator protein 1
CRYBA2 crystallin, beta A2
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein)
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DCSTAMP dendrocyte expressed seven transmembrane protein
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DSPP dentin sialophosphoprotein
EGR2 early growth response 2
ELSPBP1 epididymal sperm binding protein 1
EN2 engrailed homeobox 2
EPHA7 EPH receptor A7
EXD3 exonuclease 3'-5' domain containing 3
FBXL7 F-box and leucine-rich repeat protein 7
FLT4 fms-related tyrosine kinase 4
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRMD8 FERM domain containing 8
FRS2 fibroblast growth factor receptor substrate 2
FUZ fuzzy planar cell polarity protein
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GLS2 glutaminase 2 (liver, mitochondrial)
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HOOK1 hook microtubule-tethering protein 1
HOXA7 homeobox A7
HOXC8 homeobox C8
IFT140 intraflagellar transport 140
IL36RN interleukin 36 receptor antagonist
JMJD4 jumonji domain containing 4
JUNB jun B proto-oncogene
KCTD15 potassium channel tetramerization domain containing 15
KRT34 keratin 34, type I
LIME1 Lck interacting transmembrane adaptor 1
LOC257152 uncharacterized LOC257152
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP3K7CL MAP3K7 C-terminal like
MOCS1 molybdenum cofactor synthesis 1
MTSS1L metastasis suppressor 1-like
MUC3A mucin 3A, cell surface associated
MXRA8 matrix-remodelling associated 8
NAG18 NAG18 mRNA
NEUROD1 neuronal differentiation 1
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
ODF2 outer dense fiber of sperm tails 2
OSR2 odd-skipped related transciption factor 2
PCDH12 protocadherin 12
PCDHA5 protocadherin alpha 5
PLA2G15 phospholipase A2, group XV
PLXNA3 plexin A3
POLL polymerase (DNA directed), lambda
POMT2 protein-O-mannosyltransferase 2
PRAMEF10 PRAME family member 10
RAG2 recombination activating gene 2
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RPGRIP1L RPGRIP1-like
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
STEAP4 STEAP family member 4
STK25 serine/threonine kinase 25
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TBXAS1 thromboxane A synthase 1 (platelet)
TMEM132A transmembrane protein 132A
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TSC22D4 TSC22 domain family, member 4
TSNAXIP1 translin-associated factor X interacting protein 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
ZNF385D zinc finger protein 385D
ZNF471 zinc finger protein 471
ZNF529 zinc finger protein 529
ZNF862 zinc finger protein 862