butacaine-2728 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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196 genes differentially expressed following the butacaine-2728 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACSF2 acyl-CoA synthetase family member 2
ADGRB1 adhesion G protein-coupled receptor B1
ADRB3 adrenoceptor beta 3
AIF1 allograft inflammatory factor 1
ALOX15B arachidonate 15-lipoxygenase, type B
ANGPT1 angiopoietin 1
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
CACNG2 calcium channel, voltage-dependent, gamma subunit 2
CADM3 cell adhesion molecule 3
CAMP cathelicidin antimicrobial peptide
CD1E CD1e molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDCP1 CUB domain containing protein 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDY1 chromodomain protein, Y-linked, 1
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEP170B centrosomal protein 170B
CNGB3 cyclic nucleotide gated channel beta 3
COL11A2 collagen, type XI, alpha 2
COL6A3 collagen, type VI, alpha 3
CPNE7 copine VII
CRP C-reactive protein, pentraxin-related
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7
DLC1 DLC1 Rho GTPase activating protein
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
F11R F11 receptor
FAM110D family with sequence similarity 110, member D
FBXO31 F-box protein 31
FBXO4 F-box protein 4
FRS2 fibroblast growth factor receptor substrate 2
FZD4 frizzled class receptor 4
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPX2 glutathione peroxidase 2
HCRTR2 hypocretin (orexin) receptor 2
HDAC11 histone deacetylase 11
HLA-DOA major histocompatibility complex, class II, DO alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HOXA6 homeobox A6
HOXC10 homeobox C10
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPGDS hematopoietic prostaglandin D synthase
IGHD immunoglobulin heavy constant delta
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6
KLC2 kinesin light chain 2
KLF9 Kruppel-like factor 9
LAMC3 laminin, gamma 3
LARGE like-glycosyltransferase
LMF1 lipase maturation factor 1
LRRC75B leucine rich repeat containing 75B
LRRN3 leucine rich repeat neuronal 3
MORN1 MORN repeat containing 1
MUC8 mucin 8
MYH14 myosin, heavy chain 14, non-muscle
MYL10 myosin, light chain 10, regulatory
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
NFIB nuclear factor I/B
NTF3 neurotrophin 3
PDE4DIP phosphodiesterase 4D interacting protein
PLSCR3 phospholipid scramblase 3
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PPAP2B phosphatidic acid phosphatase type 2B
PSG11 pregnancy specific beta-1-glycoprotein 11
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11B RAB11B, member RAS oncogene family
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBPMS RNA binding protein with multiple splicing
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SECTM1 secreted and transmembrane 1
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SFRP5 secreted frizzled-related protein 5
SHB Src homology 2 domain containing adaptor protein B
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SPAG11A sperm associated antigen 11A
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
SYT5 synaptotagmin V
TGFB1 transforming growth factor, beta 1
TGFB3 transforming growth factor, beta 3
TIMP3 TIMP metallopeptidase inhibitor 3
TJAP1 tight junction associated protein 1 (peripheral)
TMPRSS2 transmembrane protease, serine 2
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TP53I11 tumor protein p53 inducible protein 11
TSPAN9 tetraspanin 9
USP2 ubiquitin specific peptidase 2
VPS9D1 VPS9 domain containing 1
WSCD2 WSC domain containing 2
ZFYVE9 zinc finger, FYVE domain containing 9
ZNF440 zinc finger protein 440

decreased expression

Symbol Name
A4GNT alpha-1,4-N-acetylglucosaminyltransferase
ABHD17B abhydrolase domain containing 17B
ACVR2B activin A receptor, type IIB
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIM2 absent in melanoma 2
ANKH ANKH inorganic pyrophosphate transport regulator
AQP9 aquaporin 9
ARID5A AT rich interactive domain 5A (MRF1-like)
ARMCX4 armadillo repeat containing, X-linked 4
ARRB1 arrestin, beta 1
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ATP7B ATPase, Cu++ transporting, beta polypeptide
BRAF B-Raf proto-oncogene, serine/threonine kinase
C16ORF45 chromosome 16 open reading frame 45
C17ORF53 chromosome 17 open reading frame 53
C19ORF73 chromosome 19 open reading frame 73
CAMKMT calmodulin-lysine N-methyltransferase
CCDC130 coiled-coil domain containing 130
CCDC57 coiled-coil domain containing 57
CD3D CD3d molecule, delta (CD3-TCR complex)
CENPT centromere protein T
CFAP45 cilia and flagella associated protein 45
CHM choroideremia (Rab escort protein 1)
CHMP1A charged multivesicular body protein 1A
CLCN5 chloride channel, voltage-sensitive 5
CLIP2 CAP-GLY domain containing linker protein 2
COMMD10 COMM domain containing 10
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DBF4B DBF4 zinc finger B
EYA3 EYA transcriptional coactivator and phosphatase 3
F3 coagulation factor III (thromboplastin, tissue factor)
FAM118A family with sequence similarity 118, member A
FANCC Fanconi anemia, complementation group C
FGL1 fibrinogen-like 1
FKBP9 FK506 binding protein 9, 63 kDa
FOXD1 forkhead box D1
FOXD2 forkhead box D2
FZD6 frizzled class receptor 6
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GK3P glycerol kinase 3 pseudogene
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRIP2 glutamate receptor interacting protein 2
GSTT1 glutathione S-transferase theta 1
HCAR3 hydroxycarboxylic acid receptor 3
HDAC7 histone deacetylase 7
HIST1H2AI histone cluster 1, H2ai
HIST1H3B histone cluster 1, H3b
HOXC8 homeobox C8
ICAM5 intercellular adhesion molecule 5, telencephalin
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IPO8 importin 8
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
MEP1B meprin A, beta
METTL16 methyltransferase like 16
MFSD11 major facilitator superfamily domain containing 11
MRAS muscle RAS oncogene homolog
MVP major vault protein
MYOZ1 myozenin 1
MYOZ3 myozenin 3
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
OLAH oleoyl-ACP hydrolase
PDE6H phosphodiesterase 6H, cGMP-specific, cone, gamma
PLD3 phospholipase D family, member 3
PLK2 polo-like kinase 2
PMP22 peripheral myelin protein 22
PORCN porcupine homolog (Drosophila)
POU5F1B POU class 5 homeobox 1B
PRSS53 protease, serine, 53
RAB33A RAB33A, member RAS oncogene family
RCAN3 RCAN family member 3
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHOB ras homolog family member B
RIBC2 RIB43A domain with coiled-coils 2
RPL10L ribosomal protein L10-like
RPL13P5 ribosomal protein L13 pseudogene 5
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
STAG3L4 stromal antigen 3-like 4 (pseudogene)
TBL1Y transducin (beta)-like 1, Y-linked
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THBS3 thrombospondin 3
TMEM242 transmembrane protein 242
TPM3 tropomyosin 3
TRIP10 thyroid hormone receptor interactor 10
TRPS1 trichorhinophalangeal syndrome I
TTC4 tetratricopeptide repeat domain 4
TUBA3C tubulin, alpha 3c
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
ZBTB33 zinc finger and BTB domain containing 33
ZNF219 zinc finger protein 219
ZNF492 zinc finger protein 492
ZNF668 zinc finger protein 668
ZNF695 zinc finger protein 695
ZNF778 zinc finger protein 778