c-Kit-IN-1_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0922319
DST dystonin 0.0680558
EEF2 eukaryotic translation elongation factor 2 0.062464
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0623149
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0550183
YAP1 Yes-associated protein 1 0.0494647
ZFAND3 zinc finger, AN1-type domain 3 0.0462078
EIF4A2 eukaryotic translation initiation factor 4A2 0.0450157
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.043943
USP34 ubiquitin specific peptidase 34 0.0434151
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0430913
TSC22D2 TSC22 domain family, member 2 0.0428418
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0405477
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0403546
HSPA8 heat shock 70kDa protein 8 0.0394429
RAB7A RAB7A, member RAS oncogene family 0.0390242
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0387298
JMJD1C jumonji domain containing 1C 0.0381327
ZSWIM6 zinc finger, SWIM-type containing 6 0.0379059
ANK2 ankyrin 2, neuronal 0.0376715
TRIO trio Rho guanine nucleotide exchange factor 0.0372313
HMGA2 high mobility group AT-hook 2 0.036876
EHBP1 EH domain binding protein 1 0.0367844
DSCAM Down syndrome cell adhesion molecule 0.0362332
FXR1 fragile X mental retardation, autosomal homolog 1 0.0345002
WNK1 WNK lysine deficient protein kinase 1 0.0343912
AFF4 AF4/FMR2 family, member 4 0.0334276
PCBP2 poly(rC) binding protein 2 0.0326279
HDAC9 histone deacetylase 9 0.032344
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.032058
INTS6 integrator complex subunit 6 0.031925
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0314963
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0306584
PICALM phosphatidylinositol binding clathrin assembly protein 0.0306465
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0304333
ADIPOR2 adiponectin receptor 2 0.0301144
FNIP1 folliculin interacting protein 1 0.0300904
SPAG9 sperm associated antigen 9 0.0299424
LPP LIM domain containing preferred translocation partner in lipoma 0.0296668
MACF1 microtubule-actin crosslinking factor 1 0.0296018
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0294478
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0288752
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0288143
TMCC1 transmembrane and coiled-coil domain family 1 0.0285686
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.028483
CARD16 caspase recruitment domain family, member 16 0.0284619
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0278343
SAMD4A sterile alpha motif domain containing 4A 0.0272729
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0272701
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0269297
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0268898
CCSER1 coiled-coil serine-rich protein 1 0.026844
TENM3 teneurin transmembrane protein 3 0.0266867
EPHA5 EPH receptor A5 0.0266211
PRKCI protein kinase C, iota 0.026553
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.026163
XPOT exportin, tRNA 0.025943
ANKRD17 ankyrin repeat domain 17 0.0257435
EXOC6B exocyst complex component 6B 0.0254973
PRKCE protein kinase C, epsilon 0.0254872
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0254552
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0252122
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0248245
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.024808
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0247468
RTN4 reticulon 4 0.0245814
PDGFC platelet derived growth factor C 0.024532
TPM3 tropomyosin 3 0.0244781
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244392
WDR43 WD repeat domain 43 0.0244047
KMT2E lysine (K)-specific methyltransferase 2E 0.0243782
CCNL1 cyclin L1 0.0238315
CAMKMT calmodulin-lysine N-methyltransferase 0.0235966
FNDC3B fibronectin type III domain containing 3B 0.0234264
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0230878
GSK3B glycogen synthase kinase 3 beta 0.0230518
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.02302
GARS1 glycyl-tRNA synthetase 1 0.0225782
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0222346
BIRC3 baculoviral IAP repeat containing 3 0.0222135
DENND1A DENN/MADD domain containing 1A 0.0218775
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0218744
USP9X ubiquitin specific peptidase 9, X-linked 0.0217617
FUBP1 far upstream element (FUSE) binding protein 1 0.0216071
TBC1D5 TBC1 domain family, member 5 0.0215792
NFIB nuclear factor I/B 0.0214681
SERTAD2 SERTA domain containing 2 0.0213047
ZNF638 zinc finger protein 638 0.0211177
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0209895
BIRC6 baculoviral IAP repeat containing 6 0.020952
DENND5A DENN/MADD domain containing 5A 0.0208416
ATF6 activating transcription factor 6 0.0206195
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0205141
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0204251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0204139
TRIP12 thyroid hormone receptor interactor 12 0.0203643
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0201623
KMT2C lysine (K)-specific methyltransferase 2C 0.0201601
LRMDA leucine rich melanocyte differentiation associated 0.0201496
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0198402

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.315971
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.297913
TMSB10 thymosin beta 10 -0.178756
AREG amphiregulin -0.134927
FTL ferritin, light polypeptide -0.0838311
ACTG1 actin gamma 1 -0.0801882
PDE4D phosphodiesterase 4D, cAMP-specific -0.0744471
MYL12B myosin, light chain 12B, regulatory -0.0736474
TPI1 triosephosphate isomerase 1 -0.0658118
RPL35A ribosomal protein L35a -0.0619677
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0608433
PTMA prothymosin, alpha -0.0589098
RPLP1 ribosomal protein, large, P1 -0.0578742
RPS27A ribosomal protein S27a -0.0555471
RPS3 ribosomal protein S3 -0.0505892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0503064
RPL19 ribosomal protein L19 -0.0498903
RPS8 ribosomal protein S8 -0.0496664
RPL26 ribosomal protein L26 -0.0492893
RPS19 ribosomal protein S19 -0.0487369
LMO7 LIM domain 7 -0.0470288
RPL34 ribosomal protein L34 -0.0463068
TPT1 tumor protein, translationally-controlled 1 -0.0458612
RPLP0 ribosomal protein, large, P0 -0.0455863
RPS13 ribosomal protein S13 -0.0452783
RPL12 ribosomal protein L12 -0.0451676
RPS16 ribosomal protein S16 -0.0440476
CNRIP1 cannabinoid receptor interacting protein 1 -0.0436599
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.043217
RPS6 ribosomal protein S6 -0.0418228
TMEM123 transmembrane protein 123 -0.0390919
EIF1 eukaryotic translation initiation factor 1 -0.0388521
RPLP2 ribosomal protein, large, P2 -0.0387196
RPS23 ribosomal protein S23 -0.0381362
MGAT4C MGAT4 family, member C -0.0379439
YBX1 Y box binding protein 1 -0.0372468
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0354628
RACK1 receptor for activated C kinase 1 -0.0354548
HMGA1 high mobility group AT-hook 1 -0.0353636
RPL32 ribosomal protein L32 -0.035285
RPL23 ribosomal protein L23 -0.0341849
SEPTIN7 septin 7 -0.0333174
RPS15 ribosomal protein S15 -0.0333108
RPL36 ribosomal protein L36 -0.0331859
RPS21 ribosomal protein S21 -0.0317688
ZBTB20 zinc finger and BTB domain containing 20 -0.0316246
IFIH1 interferon induced with helicase C domain 1 -0.0314912
RPL11 ribosomal protein L11 -0.0303745
YBX3 Y box binding protein 3 -0.0297964
RPL36A ribosomal protein L36a -0.0297434
RPS24 ribosomal protein S24 -0.0297245
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0287668
RPS27 ribosomal protein S27 -0.0284036
S100A9 S100 calcium binding protein A9 -0.0284029
RRM2 ribonucleotide reductase M2 -0.0279939
RPS29 ribosomal protein S29 -0.0278863
NAP1L1 nucleosome assembly protein 1-like 1 -0.0278174
ADGRG6 adhesion G protein-coupled receptor G6 -0.0277133
PGK1 phosphoglycerate kinase 1 -0.0275941
RPS5 ribosomal protein S5 -0.0275668
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.027133
SMC4 structural maintenance of chromosomes 4 -0.0271276
BCHE butyrylcholinesterase -0.0270839
RPL38 ribosomal protein L38 -0.0270569
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.027024
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0268706
TUBA1B tubulin, alpha 1b -0.0266241
RPS11 ribosomal protein S11 -0.0264036
KLHL24 kelch-like family member 24 -0.0258595
RPL37 ribosomal protein L37 -0.0256333
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0254841
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0250689
PFN1 profilin 1 -0.0247574
RPS14 ribosomal protein S14 -0.0247516
RPL7A ribosomal protein L7a -0.0247417
DBF4 DBF4 zinc finger -0.0246782
RPS25 ribosomal protein S25 -0.0246683
S100A6 S100 calcium binding protein A6 -0.0244545
IMMT inner membrane protein, mitochondrial -0.0242169
RPL10A ribosomal protein L10a -0.0241775
HSPE1 heat shock 10kDa protein 1 -0.0241514
RPL18 ribosomal protein L18 -0.0237919
SLC38A2 solute carrier family 38, member 2 -0.0234467
RPL27 ribosomal protein L27 -0.0232319
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0232104
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0230779
RPS10 ribosomal protein S10 -0.0230522
RPL28 ribosomal protein L28 -0.0228222
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0225524
RPL9 ribosomal protein L9 -0.022127
RPL37A ribosomal protein L37a -0.0220769
MTAP methylthioadenosine phosphorylase -0.0212847
HMGB1 high mobility group box 1 -0.0210663
VCL vinculin -0.0209087
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0207892
NEK7 NIMA-related kinase 7 -0.0203559
GCG glucagon -0.0201185
TM4SF1 transmembrane 4 L six family member 1 -0.0199612
C6ORF62 chromosome 6 open reading frame 62 -0.0199218
FAM162A family with sequence similarity 162, member A -0.0196453