| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | c-Kit-IN-1 perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the c-Kit-IN-1_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.153678 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.142965 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.138585 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.137697 |
| CREB5 | cAMP responsive element binding protein 5 | 0.128821 |
| PAX8 | paired box 8 | 0.115704 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.108521 |
| FRMD5 | FERM domain containing 5 | 0.0906977 |
| GPC6 | glypican 6 | 0.0896121 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0781318 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0764933 |
| FAT1 | FAT atypical cadherin 1 | 0.0752971 |
| NAV2 | neuron navigator 2 | 0.0664207 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.065195 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0617873 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0617564 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0603899 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.059918 |
| PTK2 | protein tyrosine kinase 2 | 0.0572558 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0560873 |
| COG5 | component of oligomeric golgi complex 5 | 0.0547415 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0531113 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0519731 |
| VCL | vinculin | 0.0511377 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0502862 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0501536 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0495435 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0493137 |
| ANK2 | ankyrin 2, neuronal | 0.0492069 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0482962 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.047031 |
| ATP13A3 | ATPase type 13A3 | 0.0466798 |
| FMNL2 | formin-like 2 | 0.0449926 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0446049 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.044336 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0442486 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0438658 |
| ASPH | aspartate beta-hydroxylase | 0.0434429 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0429728 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0425286 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0420782 |
| APP | amyloid beta (A4) precursor protein | 0.0416312 |
| MSR1 | macrophage scavenger receptor 1 | 0.0407756 |
| TLE4 | transducin-like enhancer of split 4 | 0.040698 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0400982 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0399736 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0398559 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0389994 |
| LRRC49 | leucine rich repeat containing 49 | 0.0381956 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0381103 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0377362 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.037675 |
| GLIS3 | GLIS family zinc finger 3 | 0.0375402 |
| FAR1 | fatty acyl CoA reductase 1 | 0.035973 |
| ENAH | enabled homolog (Drosophila) | 0.0359504 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0359488 |
| WDR43 | WD repeat domain 43 | 0.0357896 |
| NF1 | neurofibromin 1 | 0.0356402 |
| NRG1 | neuregulin 1 | 0.0352789 |
| KIF21A | kinesin family member 21A | 0.0352232 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0349218 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0345337 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0343149 |
| DIAPH3 | diaphanous-related formin 3 | 0.0331163 |
| OLA1 | Obg-like ATPase 1 | 0.0330315 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0328632 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0328335 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0325904 |
| ANO10 | anoctamin 10 | 0.0319345 |
| ACTN4 | actinin, alpha 4 | 0.0314869 |
| TUSC3 | tumor suppressor candidate 3 | 0.0310207 |
| SEPTIN9 | septin 9 | 0.0309107 |
| RNF216 | ring finger protein 216 | 0.0304239 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0303806 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0301449 |
| TXNRD1 | thioredoxin reductase 1 | 0.0299886 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0298238 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0291785 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0291081 |
| DGKI | diacylglycerol kinase, iota | 0.0290832 |
| SLTM | SAFB-like, transcription modulator | 0.02897 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0288808 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0281358 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0281236 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0278266 |
| PDGFC | platelet derived growth factor C | 0.0277927 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0276889 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0275938 |
| KYNU | kynureninase | 0.0273729 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0273339 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0269871 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.0265673 |
| IPO7 | importin 7 | 0.0265052 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0262134 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0261127 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0261115 |
| NAV3 | neuron navigator 3 | 0.0260347 |
| METTL15 | methyltransferase like 15 | 0.0256671 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0255786 |
| PIP4K2A | phosphatidylinositol-5-phosphate 4-kinase, type II, alpha | 0.0255409 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.167771 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.147344 |
| FRMD4A | FERM domain containing 4A | -0.132256 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.132081 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.112278 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0800699 |
| RPS6 | ribosomal protein S6 | -0.0764715 |
| NDRG1 | N-myc downstream regulated 1 | -0.0748429 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0684103 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.0653646 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0609741 |
| FTL | ferritin, light polypeptide | -0.0602747 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0581616 |
| B2M | beta-2-microglobulin | -0.05321 |
| PTMA | prothymosin, alpha | -0.0531859 |
| UBC | ubiquitin C | -0.0489015 |
| POTEF | POTE ankyrin domain family, member F | -0.0473172 |
| HLA-B | major histocompatibility complex, class I, B | -0.0471339 |
| PKM | pyruvate kinase, muscle | -0.0463733 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0459387 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0448031 |
| CTSD | cathepsin D | -0.0441967 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0432147 |
| TPM4 | tropomyosin 4 | -0.0423498 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0417976 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0416944 |
| GDF15 | growth differentiation factor 15 | -0.0403637 |
| MYADM | myeloid-associated differentiation marker | -0.0396345 |
| RPS5 | ribosomal protein S5 | -0.0394011 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0393372 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0376157 |
| PFN1 | profilin 1 | -0.0370709 |
| TRAM1 | translocation associated membrane protein 1 | -0.0368282 |
| LITAF | lipopolysaccharide-induced TNF factor | -0.0359682 |
| HBP1 | HMG-box transcription factor 1 | -0.0357958 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0356477 |
| CAVIN1 | caveolae associated protein 1 | -0.0347838 |
| DSTN | destrin (actin depolymerizing factor) | -0.0344969 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0342498 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0340931 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0339933 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0338471 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0331257 |
| RPL19 | ribosomal protein L19 | -0.03305 |
| PLK2 | polo-like kinase 2 | -0.0328091 |
| RPS8 | ribosomal protein S8 | -0.0314111 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0310205 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0306445 |
| TGM2 | transglutaminase 2 | -0.030611 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0293788 |
| MTPN | myotrophin | -0.0293775 |
| RPS27A | ribosomal protein S27a | -0.028938 |
| SBF2 | SET binding factor 2 | -0.0289221 |
| TUBA1B | tubulin, alpha 1b | -0.0287496 |
| RPL12 | ribosomal protein L12 | -0.0286066 |
| RHEB | Ras homolog enriched in brain | -0.0284566 |
| CP | ceruloplasmin (ferroxidase) | -0.0283411 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0279297 |
| NUB1 | negative regulator of ubiquitin-like proteins 1 | -0.027184 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0269956 |
| FBXO32 | F-box protein 32 | -0.0269268 |
| RPS13 | ribosomal protein S13 | -0.0268918 |
| MTDH | metadherin | -0.0268508 |
| HDGF | hepatoma-derived growth factor | -0.0267332 |
| RPS2 | ribosomal protein S2 | -0.026276 |
| RPL37A | ribosomal protein L37a | -0.0262654 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.026205 |
| S100A6 | S100 calcium binding protein A6 | -0.02614 |
| RNF220 | ring finger protein 220 | -0.0259402 |
| KLHL24 | kelch-like family member 24 | -0.0258622 |
| PLIN2 | perilipin 2 | -0.0258165 |
| RPL8 | ribosomal protein L8 | -0.0257923 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0254201 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.025379 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0253393 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.025049 |
| RPL31 | ribosomal protein L31 | -0.0250012 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248015 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0247714 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0247559 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0246857 |
| SDCBP | syndecan binding protein (syntenin) | -0.0244628 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0242821 |
| ADM | adrenomedullin | -0.0242246 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0241016 |
| CALR | calreticulin | -0.0240694 |
| CALD1 | caldesmon 1 | -0.0240636 |
| RPLP2 | ribosomal protein, large, P2 | -0.0240483 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0240333 |
| STOM | stomatin | -0.0240207 |
| RPS23 | ribosomal protein S23 | -0.0236475 |
| TPM1 | tropomyosin 1 (alpha) | -0.0233984 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0233699 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0233625 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0232194 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0227541 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0227391 |
| TLN1 | talin 1 | -0.0227191 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0225505 |
| HELZ | helicase with zinc finger | -0.0224419 |
