c-Kit-IN-1_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.181234
ASPH aspartate beta-hydroxylase 0.156065
FLNB filamin B, beta 0.136653
TRIO trio Rho guanine nucleotide exchange factor 0.123516
SLC35F3 solute carrier family 35, member F3 0.120158
EFNA5 ephrin-A5 0.118725
GLS2 glutaminase 2 (liver, mitochondrial) 0.112016
GRB10 growth factor receptor-bound protein 10 0.0989923
TRRAP transformation/transcription domain-associated protein 0.088663
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0835583
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0831744
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0774132
TNPO1 transportin 1 0.0737651
UBA6 ubiquitin-like modifier activating enzyme 6 0.0730603
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0678854
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.066466
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0582198
SEPTIN10 septin 10 0.0569859
LMTK2 lemur tyrosine kinase 2 0.0563356
HSPA8 heat shock 70kDa protein 8 0.0548354
PTK2 protein tyrosine kinase 2 0.0541961
MACF1 microtubule-actin crosslinking factor 1 0.0531347
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0500703
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0486753
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0483861
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0478121
CORO1C coronin, actin binding protein, 1C 0.0474478
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 0.0474111
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0471098
F3 coagulation factor III (thromboplastin, tissue factor) 0.0459777
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0457939
IGFBP3 insulin-like growth factor binding protein 3 0.0457903
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0453876
ARHGAP29 Rho GTPase activating protein 29 0.0430865
THSD4 thrombospondin, type I, domain containing 4 0.0407933
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0398475
SERINC5 serine incorporator 5 0.0387451
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0387055
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0382058
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0372043
FAT1 FAT atypical cadherin 1 0.0369177
NAMPT nicotinamide phosphoribosyltransferase 0.0368716
CMIP c-Maf inducing protein 0.0359759
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0359101
FMNL2 formin-like 2 0.0356485
ITPRID2 ITPR interacting domain containing 2 0.0355362
PRELID2 PRELI domain containing 2 0.0346799
OLA1 Obg-like ATPase 1 0.0343344
ATP13A3 ATPase type 13A3 0.0342234
ZFAND3 zinc finger, AN1-type domain 3 0.0341778
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0338248
EXT1 exostosin glycosyltransferase 1 0.0334902
DOCK5 dedicator of cytokinesis 5 0.0329149
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0324954
NAV3 neuron navigator 3 0.0317877
PPARD peroxisome proliferator-activated receptor delta 0.0315937
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0309257
MYH9 myosin, heavy chain 9, non-muscle 0.0305033
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0302123
PDZD8 PDZ domain containing 8 0.0300225
OSBPL3 oxysterol binding protein-like 3 0.029987
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0299359
GCLC glutamate-cysteine ligase, catalytic subunit 0.0298826
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0296396
RUNX1 runt-related transcription factor 1 0.0294215
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0290564
CHD1 chromodomain helicase DNA binding protein 1 0.0290358
TPD52 tumor protein D52 0.0290346
GARS1 glycyl-tRNA synthetase 1 0.0288524
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0288388
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.0287834
IPO7 importin 7 0.0283995
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.0281968
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0275589
STK4 serine/threonine kinase 4 0.0274391
TFRC transferrin receptor 0.0273092
SAMD4A sterile alpha motif domain containing 4A 0.0271517
ANO6 anoctamin 6 0.0269463
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0268886
NALF1 NALCN channel auxiliary factor 1 0.02651
CCNY cyclin Y 0.0264311
KIF21A kinesin family member 21A 0.0264114
BMP2K BMP2 inducible kinase 0.0263766
CYRIB CYFIP related Rac1 interactor B 0.0263445
SIK3 SIK family kinase 3 0.026184
ZEB1 zinc finger E-box binding homeobox 1 0.0261664
PLEC plectin 0.026114
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.025873
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0258074
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0257011
RAB10 RAB10, member RAS oncogene family 0.0256212
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0255505
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0253423
FAM107B family with sequence similarity 107, member B 0.0248831
STK39 serine threonine kinase 39 0.0247851
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.024559
SOWAHC sosondowah ankyrin repeat domain family member C 0.0244362
SND1 staphylococcal nuclease and tudor domain containing 1 0.0239949
HKDC1 hexokinase domain containing 1 0.0239129

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.14784
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.139325
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12303
PTMA prothymosin, alpha -0.119768
VIM vimentin -0.115368
TPT1 tumor protein, translationally-controlled 1 -0.102572
FTH1 ferritin, heavy polypeptide 1 -0.102041
POTEF POTE ankyrin domain family, member F -0.0943387
LMO7 LIM domain 7 -0.0934259
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0774127
RPL37A ribosomal protein L37a -0.0722407
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0718708
HMGA1 high mobility group AT-hook 1 -0.0702354
FTL ferritin, light polypeptide -0.0685945
S100A10 S100 calcium binding protein A10 -0.0648401
RIOK3 RIO kinase 3 -0.0640421
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0606765
B2M beta-2-microglobulin -0.059124
RPLP2 ribosomal protein, large, P2 -0.0573477
RPL31 ribosomal protein L31 -0.0544225
RPS6 ribosomal protein S6 -0.0536553
RPS3 ribosomal protein S3 -0.0533339
SKAP2 src kinase associated phosphoprotein 2 -0.0529679
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0504737
PERP PERP, TP53 apoptosis effector -0.0493227
AKAP12 A kinase (PRKA) anchor protein 12 -0.0493224
RPS27A ribosomal protein S27a -0.0490246
RPL12 ribosomal protein L12 -0.0485566
RPL8 ribosomal protein L8 -0.0481758
RPS13 ribosomal protein S13 -0.0455463
AKAP9 A kinase (PRKA) anchor protein 9 -0.0454764
ANXA2 annexin A2 -0.0447799
SQSTM1 sequestosome 1 -0.0447014
EZR ezrin -0.0441748
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0427887
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0424409
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0416804
RPLP1 ribosomal protein, large, P1 -0.0415845
KRT18 keratin 18, type I -0.04141
UBC ubiquitin C -0.0408921
RPS8 ribosomal protein S8 -0.0408695
S100A6 S100 calcium binding protein A6 -0.0406406
RPS12 ribosomal protein S12 -0.0400285
RPS23 ribosomal protein S23 -0.039371
S100A11 S100 calcium binding protein A11 -0.0393004
SP100 SP100 nuclear antigen -0.0390788
RPL35A ribosomal protein L35a -0.0383513
EIF1 eukaryotic translation initiation factor 1 -0.0379955
WASF2 WAS protein family, member 2 -0.0375765
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0375282
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0373854
RPL11 ribosomal protein L11 -0.0367391
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0365953
SLC38A2 solute carrier family 38, member 2 -0.0365403
OGA O-GlcNAcase -0.0360404
KLK10 kallikrein-related peptidase 10 -0.0357342
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0356036
RPL26 ribosomal protein L26 -0.0354315
TM4SF1 transmembrane 4 L six family member 1 -0.0354264
LY6E lymphocyte antigen 6 complex, locus E -0.0353271
MXD1 MAX dimerization protein 1 -0.0351878
TXNIP thioredoxin interacting protein -0.03476
EGR1 early growth response 1 -0.0347525
OPTN optineurin -0.034563
EMP1 epithelial membrane protein 1 -0.0344704
GCC2 GRIP and coiled-coil domain containing 2 -0.0343221
KRT19 keratin 19, type I -0.0341741
LAMA4 laminin, alpha 4 -0.0336912
RPS21 ribosomal protein S21 -0.0335485
MUC17 mucin 17, cell surface associated -0.0334983
EGFR epidermal growth factor receptor -0.0330577
SDC4 syndecan 4 -0.0320205
RPL37 ribosomal protein L37 -0.0309794
RPL19 ribosomal protein L19 -0.0308723
RPS29 ribosomal protein S29 -0.0308017
UBE2B ubiquitin-conjugating enzyme E2B -0.0304775
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -0.0301479
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0296017
RPL34 ribosomal protein L34 -0.0294703
ERBIN erbb2 interacting protein -0.0293237
SMC3 structural maintenance of chromosomes 3 -0.0291065
RPS27 ribosomal protein S27 -0.0284052
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0283961
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283787
RPS14 ribosomal protein S14 -0.0282845
RPS2 ribosomal protein S2 -0.0282488
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0278449
KLF6 Kruppel-like factor 6 -0.0275846
RB1CC1 RB1-inducible coiled-coil 1 -0.0273672
MAML2 mastermind-like 2 (Drosophila) -0.0272728
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0272341
RPL36 ribosomal protein L36 -0.0269797
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.026806
S100A4 S100 calcium binding protein A4 -0.026694
RPL13A ribosomal protein L13a -0.0266706
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0265038
JUP junction plakoglobin -0.0264357
AKAP13 A kinase (PRKA) anchor protein 13 -0.0262742
RPS17 ribosomal protein S17 -0.0261658
SACK1A scaffolding CK1 anchoring protein A -0.0258243