c-Kit-IN-1_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.120385
VMP1 vacuole membrane protein 1 0.117015
CDK12 cyclin-dependent kinase 12 0.110628
CLTC clathrin, heavy chain (Hc) 0.104503
LPP LIM domain containing preferred translocation partner in lipoma 0.103739
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0861774
CEP250 centrosomal protein 250kDa 0.0854072
ITCH itchy E3 ubiquitin protein ligase 0.0823221
NRIP1 nuclear receptor interacting protein 1 0.080305
NCOA3 nuclear receptor coactivator 3 0.0749926
TRIO trio Rho guanine nucleotide exchange factor 0.0733903
EGFR epidermal growth factor receptor 0.0733851
SRCIN1 SRC kinase signaling inhibitor 1 0.0706174
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0636892
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0636075
CATSPERB catsper channel auxiliary subunit beta 0.063409
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.061815
ASPH aspartate beta-hydroxylase 0.061699
MCL1 myeloid cell leukemia 1 0.0603443
THSD4 thrombospondin, type I, domain containing 4 0.0596947
EXT1 exostosin glycosyltransferase 1 0.059514
FNDC3A fibronectin type III domain containing 3A 0.0590846
GSK3B glycogen synthase kinase 3 beta 0.0584056
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0582172
DTNA dystrobrevin, alpha 0.0581832
PTK2 protein tyrosine kinase 2 0.0565919
RAB7A RAB7A, member RAS oncogene family 0.0557326
PLEC plectin 0.0543044
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0525031
ADARB1 adenosine deaminase, RNA-specific, B1 0.0519077
MSI2 musashi RNA-binding protein 2 0.05155
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0511245
YAP1 Yes-associated protein 1 0.0510463
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0507246
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0503917
INHBA inhibin, beta A 0.0490714
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0490038
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0484462
CREB5 cAMP responsive element binding protein 5 0.0476386
MYO1D myosin ID 0.0465886
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0464914
SAMD4A sterile alpha motif domain containing 4A 0.0461583
DENND1A DENN/MADD domain containing 1A 0.045852
FAM219A family with sequence similarity 219, member A 0.0448642
VCP valosin containing protein 0.0439375
INTS6 integrator complex subunit 6 0.0437717
KMT2C lysine (K)-specific methyltransferase 2C 0.0432409
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0427991
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0425819
KIF1A kinesin family member 1A 0.0423714
SP100 SP100 nuclear antigen 0.0421622
USO1 USO1 vesicle transport factor 0.0420982
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0419741
NCOA6 nuclear receptor coactivator 6 0.0419409
STRN3 striatin, calmodulin binding protein 3 0.0416207
RAB22A RAB22A, member RAS oncogene family 0.0415524
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.041223
MYO5B myosin VB 0.0407762
CD44 CD44 molecule (Indian blood group) 0.0405777
TOM1L1 target of myb1 (chicken)-like 1 0.0403957
ZFAND3 zinc finger, AN1-type domain 3 0.0402396
PATJ PATJ crumbs cell polarity complex component 0.0402252
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0401467
FAM168A family with sequence similarity 168, member A 0.0398455
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0396028
HSPA8 heat shock 70kDa protein 8 0.039577
RCOR1 REST corepressor 1 0.0395374
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0382135
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0380364
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0378786
SAMD5 sterile alpha motif domain containing 5 0.0377424
GRB10 growth factor receptor-bound protein 10 0.0375694
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0371335
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.0369035
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0360689
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0358345
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0356061
MIPOL1 mirror-image polydactyly 1 0.035549
ZC3H11A zinc finger CCCH-type containing 11A 0.0354263
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0350048
PRRC2B proline-rich coiled-coil 2B 0.0348567
UNC13B unc-13 homolog B (C. elegans) 0.0345414
CYFIP1 cytoplasmic FMR1 interacting protein 1 0.0344329
VEGFA vascular endothelial growth factor A 0.034245
RABGAP1 RAB GTPase activating protein 1 0.0339037
MTSS1 metastasis suppressor 1 0.0335191
SBF2 SET binding factor 2 0.0330811
PRKCA protein kinase C, alpha 0.0329823
ATXN1 ataxin 1 0.0329605
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0328841
ZSWIM6 zinc finger, SWIM-type containing 6 0.0328243
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0324266
KIAA1217 KIAA1217 0.0323496
RIMS2 regulating synaptic membrane exocytosis 2 0.0322689
KDM2A lysine (K)-specific demethylase 2A 0.0321469
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0317763
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.031607
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0316052
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0315305
CXCL8 chemokine (C-X-C motif) ligand 8 0.0314891

decreased expression

Symbol Name Standardized Value
RPL19 ribosomal protein L19 -0.104838
FTH1 ferritin, heavy polypeptide 1 -0.0925779
RPL23 ribosomal protein L23 -0.0694326
PTMA prothymosin, alpha -0.0634248
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0597787
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0568986
GRB7 growth factor receptor-bound protein 7 -0.0501478
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0500309
ZMYND8 zinc finger, MYND-type containing 8 -0.0477999
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.043931
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0362245
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0357193
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0347585
RPS8 ribosomal protein S8 -0.0331472
CCNI cyclin I -0.0330365
TPT1 tumor protein, translationally-controlled 1 -0.0329817
NCOA7 nuclear receptor coactivator 7 -0.032833
TMSB10 thymosin beta 10 -0.0324841
YPEL2 yippee-like 2 (Drosophila) -0.0321945
RPS3 ribosomal protein S3 -0.0306607
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0305129
WSB1 WD repeat and SOCS box containing 1 -0.0300631
RPS6 ribosomal protein S6 -0.0291827
ACTG1 actin gamma 1 -0.0284112
RAD21 RAD21 homolog (S. pombe) -0.0283604
MT2A metallothionein 2A -0.027718
RPL35A ribosomal protein L35a -0.0276873
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0274012
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0272905
AHNAK AHNAK nucleoprotein -0.0272787
RPS19 ribosomal protein S19 -0.026503
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0257158
RPL12 ribosomal protein L12 -0.0254769
MYL12B myosin, light chain 12B, regulatory -0.024265
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0241084
TMEM123 transmembrane protein 123 -0.0240374
NAMPT nicotinamide phosphoribosyltransferase -0.0238526
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0235797
RPLP0 ribosomal protein, large, P0 -0.0235478
ANKRD36C ankyrin repeat domain 36C -0.0230186
DEK DEK proto-oncogene -0.0225414
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.0225246
SEPTIN7 septin 7 -0.0225162
UGCG UDP-glucose ceramide glucosyltransferase -0.0224636
MIEN1 migration and invasion enhancer 1 -0.0214849
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0209766
GNAS GNAS complex locus -0.0209622
RPLP2 ribosomal protein, large, P2 -0.0209161
S100A9 S100 calcium binding protein A9 -0.0208222
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0207693
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0206851
UQCRB ubiquinol-cytochrome c reductase binding protein -0.020608
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0205131
TMSB4X thymosin beta 4, X-linked -0.0204514
S100A8 S100 calcium binding protein A8 -0.0203973
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0203857
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0201906
RPLP1 ribosomal protein, large, P1 -0.0201801
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0199608
PFDN4 prefoldin subunit 4 -0.0197608
HMGB1 high mobility group box 1 -0.0197018
PRR11 proline rich 11 -0.0194873
EIF1 eukaryotic translation initiation factor 1 -0.0193893
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0192325
SERF2 small EDRK-rich factor 2 -0.0184481
ARHGAP29 Rho GTPase activating protein 29 -0.0184402
ZNF217 zinc finger protein 217 -0.018282
NIPSNAP2 nipsnap homolog 2 -0.0177893
RPL34 ribosomal protein L34 -0.0177788
CNRIP1 cannabinoid receptor interacting protein 1 -0.0177638
TXNRD1 thioredoxin reductase 1 -0.0175806
RPL26 ribosomal protein L26 -0.0174747
SMC4 structural maintenance of chromosomes 4 -0.0174188
CENPF centromere protein F, 350/400kDa -0.017388
NDUFA4 NDUFA4, mitochondrial complex associated -0.0173539
RRBP1 ribosome binding protein 1 -0.0172009
RPS27A ribosomal protein S27a -0.0171164
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0170686
H1-0 H1.0 linker histone -0.0169483
TMC5 transmembrane channel-like 5 -0.0168647
YBX1 Y box binding protein 1 -0.0167815
MARCKS myristoylated alanine-rich protein kinase C substrate -0.016529
PERP PERP, TP53 apoptosis effector -0.0164181
TPI1 triosephosphate isomerase 1 -0.0163641
RPL31 ribosomal protein L31 -0.0162854
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0161024
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0160906
BCAS1 breast carcinoma amplified sequence 1 -0.0160291
PARP1 poly (ADP-ribose) polymerase 1 -0.0159917
RPS12 ribosomal protein S12 -0.0155918
VIM vimentin -0.0153593
RPL35 ribosomal protein L35 -0.0152425
RPL8 ribosomal protein L8 -0.0151668
TUBB tubulin, beta class I -0.0151168
STK17A serine/threonine kinase 17a -0.0150952
RPS29 ribosomal protein S29 -0.0150435
SMIM14 small integral membrane protein 14 -0.015024
DUSP4 dual specificity phosphatase 4 -0.0148486
RPS27 ribosomal protein S27 -0.0146912
YBX3 Y box binding protein 3 -0.0146644