c-Kit-IN-1_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.167408
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.127362
ANK2 ankyrin 2, neuronal 0.102693
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0979137
DST dystonin 0.0962518
NUP58 nucleoporin 58 0.093369
SMYD3 SET and MYND domain containing 3 0.0928406
KMT2C lysine (K)-specific methyltransferase 2C 0.0915063
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0853913
TENM3 teneurin transmembrane protein 3 0.0806211
ZNF638 zinc finger protein 638 0.0765324
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0749864
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0705671
ATRN attractin 0.0691457
ERBB4 erb-b2 receptor tyrosine kinase 4 0.068563
COL5A2 collagen, type V, alpha 2 0.0684441
ZNF292 zinc finger protein 292 0.0682947
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0679565
ZFAND3 zinc finger, AN1-type domain 3 0.0659015
SOX5 SRY (sex determining region Y)-box 5 0.0637391
JMJD1C jumonji domain containing 1C 0.0630928
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0624814
PIAS2 protein inhibitor of activated STAT, 2 0.0616568
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0601824
CABIN1 calcineurin binding protein 1 0.0589345
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.057969
USP9X ubiquitin specific peptidase 9, X-linked 0.0569155
DOCK3 dedicator of cytokinesis 3 0.0568509
PTK2 protein tyrosine kinase 2 0.0558483
EEF2 eukaryotic translation elongation factor 2 0.0545483
AUTS2 autism susceptibility candidate 2 0.054337
GPHN gephyrin 0.0520286
NFIA nuclear factor I/A 0.0520042
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0501573
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0499898
RAD51B RAD51 paralog B 0.0499246
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0492335
TOX thymocyte selection-associated high mobility group box 0.0492149
NGLY1 N-glycanase 1 0.0486958
RERE arginine-glutamic acid dipeptide (RE) repeats 0.048218
CHD7 chromodomain helicase DNA binding protein 7 0.0480939
MATR3 matrin 3 0.0477221
CDC73 cell division cycle 73 0.0475063
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0472391
SEC63 SEC63 homolog (S. cerevisiae) 0.0469905
SLIT2 slit homolog 2 (Drosophila) 0.0469207
GARS1 glycyl-tRNA synthetase 1 0.045253
TPD52 tumor protein D52 0.0451864
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.045178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0448323
ARFGEF3 ARFGEF family member 3 0.0447418
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0444642
TAS2R14 taste receptor, type 2, member 14 0.04426
TTC28 tetratricopeptide repeat domain 28 0.0438289
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0436957
PCBP2 poly(rC) binding protein 2 0.0436731
YEATS2 YEATS domain containing 2 0.0435587
CLIC4 chloride intracellular channel 4 0.0434395
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.043131
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0426989
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0426703
CHSY1 chondroitin sulfate synthase 1 0.0423246
KDM1A lysine (K)-specific demethylase 1A 0.0421891
ESYT2 extended synaptotagmin-like protein 2 0.0408962
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0404896
KDM3A lysine (K)-specific demethylase 3A 0.0404726
SFPQ splicing factor proline/glutamine-rich 0.0396384
APP amyloid beta (A4) precursor protein 0.0395445
MED13 mediator complex subunit 13 0.0393878
CAMKMT calmodulin-lysine N-methyltransferase 0.0389953
BIRC6 baculoviral IAP repeat containing 6 0.0383471
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0380574
TENT4A terminal nucleotidyltransferase 4A 0.0380386
PUM2 pumilio RNA-binding family member 2 0.0379412
GRID2 glutamate receptor, ionotropic, delta 2 0.0378845
DIDO1 death inducer-obliterator 1 0.0377448
FNBP1L formin binding protein 1-like 0.0372166
CCNY cyclin Y 0.0368516
ADGRG6 adhesion G protein-coupled receptor G6 0.0368342
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0365155
STRN3 striatin, calmodulin binding protein 3 0.0365105
IPO7 importin 7 0.0358442
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0355719
TBK1 TANK-binding kinase 1 0.0354447
LDHA lactate dehydrogenase A 0.0350412
USP34 ubiquitin specific peptidase 34 0.0348328
FUBP1 far upstream element (FUSE) binding protein 1 0.0344675
NBAS neuroblastoma amplified sequence 0.0344515
PCNX1 pecanex 1 0.0343863
SSBP2 single-stranded DNA binding protein 2 0.034306
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0341236
EWSR1 EWS RNA-binding protein 1 0.0341075
GSK3B glycogen synthase kinase 3 beta 0.0340278
NCOR1 nuclear receptor corepressor 1 0.0339673
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0339271
RYBP RING1 and YY1 binding protein 0.0338751
UBE3C ubiquitin protein ligase E3C 0.0336877
TTC3 tetratricopeptide repeat domain 3 0.0335138
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0334269
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0332733

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0703554
PTMA prothymosin, alpha -0.0667228
RPS6 ribosomal protein S6 -0.0665508
NPAS3 neuronal PAS domain protein 3 -0.0628087
RPS8 ribosomal protein S8 -0.0516599
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0509095
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0458804
TMSB10 thymosin beta 10 -0.0439267
RPL19 ribosomal protein L19 -0.0430751
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.041859
RPS29 ribosomal protein S29 -0.0418036
TPT1 tumor protein, translationally-controlled 1 -0.0402121
RPL11 ribosomal protein L11 -0.0394587
RPL31 ribosomal protein L31 -0.0393111
RPS27A ribosomal protein S27a -0.0382145
IFI6 interferon, alpha-inducible protein 6 -0.0380265
RPLP1 ribosomal protein, large, P1 -0.0363682
RPS3 ribosomal protein S3 -0.0350885
RPL13A ribosomal protein L13a -0.0348424
RPLP2 ribosomal protein, large, P2 -0.0345067
RPL35A ribosomal protein L35a -0.0327627
RPS13 ribosomal protein S13 -0.0326389
TNRC6B trinucleotide repeat containing 6B -0.0323763
FTL ferritin, light polypeptide -0.0314132
RPL37A ribosomal protein L37a -0.0312992
ZBTB20 zinc finger and BTB domain containing 20 -0.0310858
RPS21 ribosomal protein S21 -0.0301782
RPL34 ribosomal protein L34 -0.0296272
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.029508
VIM vimentin -0.0286194
NEBL nebulette -0.0284739
RPS15 ribosomal protein S15 -0.0282714
ACTG1 actin gamma 1 -0.0276982
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0276663
RPL9 ribosomal protein L9 -0.027368
SOX4 SRY (sex determining region Y)-box 4 -0.0273064
RPL36 ribosomal protein L36 -0.0272545
HMGB1 high mobility group box 1 -0.0259594
RPL12 ribosomal protein L12 -0.0256163
RPS19 ribosomal protein S19 -0.0252758
RPS11 ribosomal protein S11 -0.0251983
RPS16 ribosomal protein S16 -0.0243139
RPL26 ribosomal protein L26 -0.024255
RPS24 ribosomal protein S24 -0.0238908
RPL28 ribosomal protein L28 -0.0237678
RPS12 ribosomal protein S12 -0.0236783
B2M beta-2-microglobulin -0.0234111
RPL8 ribosomal protein L8 -0.0233348
RPS23 ribosomal protein S23 -0.0232229
RPS25 ribosomal protein S25 -0.0231617
HMGA1 high mobility group AT-hook 1 -0.0227792
MT2A metallothionein 2A -0.0223538
RPS17 ribosomal protein S17 -0.0218799
EMP1 epithelial membrane protein 1 -0.0217252
RACK1 receptor for activated C kinase 1 -0.021409
EIF1 eukaryotic translation initiation factor 1 -0.0212462
ZNF217 zinc finger protein 217 -0.0212281
RPL22L1 ribosomal protein L22-like 1 -0.0211355
BPTF bromodomain PHD finger transcription factor -0.0210482
HLA-B major histocompatibility complex, class I, B -0.0207821
RPL38 ribosomal protein L38 -0.0200859
RPS10 ribosomal protein S10 -0.0199864
DEK DEK proto-oncogene -0.019653
RFC3 replication factor C (activator 1) 3, 38kDa -0.0190712
RPLP0 ribosomal protein, large, P0 -0.0190198
TOP2A topoisomerase (DNA) II alpha 170kDa -0.018598
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0184127
TOM1L2 target of myb1-like 2 (chicken) -0.018232
ISG15 ISG15 ubiquitin-like modifier -0.0178542
MYL12B myosin, light chain 12B, regulatory -0.0177947
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0175925
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0173713
FTH1 ferritin, heavy polypeptide 1 -0.0173024
AKAP9 A kinase (PRKA) anchor protein 9 -0.0173012
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0172207
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0172099
RSL1D1 ribosomal L1 domain containing 1 -0.0172019
S100A10 S100 calcium binding protein A10 -0.0168667
DCAF7 DDB1 and CUL4 associated factor 7 -0.0166916
CANX calnexin -0.0165953
PFN1 profilin 1 -0.0165444
KAT6B K(lysine) acetyltransferase 6B -0.0163685
RPS20 ribosomal protein S20 -0.0162347
ANXA2 annexin A2 -0.016229
RPS14 ribosomal protein S14 -0.0161759
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0159575
TPM4 tropomyosin 4 -0.0158361
FN1 fibronectin 1 -0.0158049
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -0.0157231
GNAS GNAS complex locus -0.0151528
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0151452
HDAC4 histone deacetylase 4 -0.015079
RPS5 ribosomal protein S5 -0.0149664
AFG2A AFG2 AAA ATPase homolog A -0.0147418
RPL27 ribosomal protein L27 -0.0144867
INSR insulin receptor -0.014363
LARS1 leucyl-tRNA synthetase 1 -0.0142979
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0141547
ITSN1 intersectin 1 (SH3 domain protein) -0.0141086