c-Kit-IN-1_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD109 CD109 molecule 0.135743
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.114293
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0943054
NBAS neuroblastoma amplified sequence 0.0869799
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0817041
BACE2 beta-site APP-cleaving enzyme 2 0.0786278
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0735768
KMT2C lysine (K)-specific methyltransferase 2C 0.072138
ASPH aspartate beta-hydroxylase 0.0680003
PTPRM protein tyrosine phosphatase, receptor type, M 0.0679012
NAMPT nicotinamide phosphoribosyltransferase 0.061672
CPED1 cadherin-like and PC-esterase domain containing 1 0.0586288
GPC6 glypican 6 0.0539116
DST dystonin 0.0535467
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0534827
PRELID2 PRELI domain containing 2 0.0525105
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0516123
IVNS1ABP influenza virus NS1A binding protein 0.0515813
DOCK4 dedicator of cytokinesis 4 0.04999
SND1 staphylococcal nuclease and tudor domain containing 1 0.0476855
SRPK2 SRSF protein kinase 2 0.0474247
SETBP1 SET binding protein 1 0.046164
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0452304
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0451476
CABIN1 calcineurin binding protein 1 0.0442462
NAV2 neuron navigator 2 0.0432912
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0431863
FMN1 formin 1 0.0428596
EXOC4 exocyst complex component 4 0.0427161
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0424298
ANK2 ankyrin 2, neuronal 0.0418736
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0415052
NUP58 nucleoporin 58 0.0411177
ZNF638 zinc finger protein 638 0.0410739
CDC73 cell division cycle 73 0.0404909
GPHN gephyrin 0.0403918
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0401039
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0387425
STXBP1 syntaxin binding protein 1 0.0385535
COG5 component of oligomeric golgi complex 5 0.0384549
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0379394
PTPRG protein tyrosine phosphatase, receptor type, G 0.0370594
TNIK TRAF2 and NCK interacting kinase 0.0368201
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0362161
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0360235
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.035934
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0357736
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0357689
SLC39A11 solute carrier family 39, member 11 0.0350259
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0347235
PDE4D phosphodiesterase 4D, cAMP-specific 0.03452
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0340471
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0337286
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0332956
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0331412
CTTNBP2 cortactin binding protein 2 0.0329817
SEPTIN9 septin 9 0.0329041
BHLHE40 basic helix-loop-helix family, member e40 0.0317495
ZFAND3 zinc finger, AN1-type domain 3 0.0314624
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 0.0312782
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0312751
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0310495
STRIP2 striatin interacting protein 2 0.0308406
RUNX1 runt-related transcription factor 1 0.0302683
FMNL2 formin-like 2 0.0301387
ARFGEF3 ARFGEF family member 3 0.0300282
POM121 POM121 transmembrane nucleoporin 0.0300019
UBE3C ubiquitin protein ligase E3C 0.0299941
GMDS GDP-mannose 4,6-dehydratase 0.0294824
TBC1D22A TBC1 domain family, member 22A 0.029415
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0291871
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0288307
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0287235
ANO6 anoctamin 6 0.0285631
BIRC6 baculoviral IAP repeat containing 6 0.0284618
NDRG1 N-myc downstream regulated 1 0.0281954
LRMDA leucine rich melanocyte differentiation associated 0.027541
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0272399
USP34 ubiquitin specific peptidase 34 0.0270135
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0268419
PTK2 protein tyrosine kinase 2 0.0268051
TRRAP transformation/transcription domain-associated protein 0.0267213
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0265892
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0265694
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0264163
PAX3 paired box 3 0.0263384
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0263206
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0257423
MEIS2 Meis homeobox 2 0.0255415
TBC1D5 TBC1 domain family, member 5 0.0254799
MACF1 microtubule-actin crosslinking factor 1 0.0252595
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0251068
IL1RAP interleukin 1 receptor accessory protein 0.0249994
ZNF827 zinc finger protein 827 0.0249001
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0247678
USP37 ubiquitin specific peptidase 37 0.024751
FNDC3A fibronectin type III domain containing 3A 0.0243765
NAV1 neuron navigator 1 0.024049
ANKRD36 ankyrin repeat domain 36 0.0236774
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0234338

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.4332
VIM vimentin -0.241513
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.186212
FN1 fibronectin 1 -0.112469
MT2A metallothionein 2A -0.0834911
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0806898
ACTG1 actin gamma 1 -0.0803109
TMSB10 thymosin beta 10 -0.0747394
NLGN1 neuroligin 1 -0.0733785
HLA-B major histocompatibility complex, class I, B -0.0701961
S100A6 S100 calcium binding protein A6 -0.0652574
IGFBP5 insulin-like growth factor binding protein 5 -0.0604016
RPS8 ribosomal protein S8 -0.0562448
RPLP1 ribosomal protein, large, P1 -0.0551589
IFI16 interferon, gamma-inducible protein 16 -0.0547261
PTMA prothymosin, alpha -0.0547173
TNNC1 troponin C type 1 (slow) -0.0494003
AKAP12 A kinase (PRKA) anchor protein 12 -0.0490259
UBC ubiquitin C -0.0484055
TPT1 tumor protein, translationally-controlled 1 -0.0480821
RPL37A ribosomal protein L37a -0.0443735
FTL ferritin, light polypeptide -0.0440973
RPS6 ribosomal protein S6 -0.0427572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0422837
RPS12 ribosomal protein S12 -0.0399548
RPS3 ribosomal protein S3 -0.0389263
RPLP2 ribosomal protein, large, P2 -0.0383248
RPS27A ribosomal protein S27a -0.0374888
RPL19 ribosomal protein L19 -0.0373048
LMNA lamin A/C -0.0367062
RPS19 ribosomal protein S19 -0.0365685
IER3 immediate early response 3 -0.03654
WSB1 WD repeat and SOCS box containing 1 -0.0358969
RPL11 ribosomal protein L11 -0.0358001
S100A9 S100 calcium binding protein A9 -0.0350261
RPL35A ribosomal protein L35a -0.0348575
RPL26 ribosomal protein L26 -0.0347287
NPC1 Niemann-Pick disease, type C1 -0.0341636
IFITM3 interferon induced transmembrane protein 3 -0.0341315
FRMD4A FERM domain containing 4A -0.0331576
B2M beta-2-microglobulin -0.033157
MACROD2 MACRO domain containing 2 -0.0316354
ENO1 enolase 1, (alpha) -0.0314793
PDE10A phosphodiesterase 10A -0.0313525
PKM pyruvate kinase, muscle -0.0307783
TAGLN2 transgelin 2 -0.0307764
IFI6 interferon, alpha-inducible protein 6 -0.0307756
TM4SF1 transmembrane 4 L six family member 1 -0.0303422
CD63 CD63 molecule -0.0299617
AHNAK AHNAK nucleoprotein -0.0292742
RPL34 ribosomal protein L34 -0.0286898
RPL31 ribosomal protein L31 -0.0274494
RPS13 ribosomal protein S13 -0.0269516
RPLP0 ribosomal protein, large, P0 -0.0269192
GNAS GNAS complex locus -0.026873
S100A10 S100 calcium binding protein A10 -0.0267568
HILPDA hypoxia inducible lipid droplet-associated -0.0266409
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0266131
COL19A1 collagen, type XIX, alpha 1 -0.0264246
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0263363
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0259467
RPL12 ribosomal protein L12 -0.02592
CTSD cathepsin D -0.0256791
A2M alpha-2-macroglobulin -0.0254952
RPS5 ribosomal protein S5 -0.0254913
RPL36 ribosomal protein L36 -0.0254443
RPS24 ribosomal protein S24 -0.0254333
RPS29 ribosomal protein S29 -0.0253041
RPL9 ribosomal protein L9 -0.0250349
ZMYND8 zinc finger, MYND-type containing 8 -0.0249271
VGF VGF nerve growth factor inducible -0.0246174
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0245281
RTN4 reticulon 4 -0.0243586
RPS17 ribosomal protein S17 -0.0241032
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0235287
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.0232447
RPL23 ribosomal protein L23 -0.0230442
ARHGAP5 Rho GTPase activating protein 5 -0.0229586
FTH1 ferritin, heavy polypeptide 1 -0.0229501
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0228789
MTPN myotrophin -0.0228077
TPI1 triosephosphate isomerase 1 -0.0225805
HLA-A major histocompatibility complex, class I, A -0.0223565
TNRC6B trinucleotide repeat containing 6B -0.0218233
MTDH metadherin -0.0217686
RPL13A ribosomal protein L13a -0.0217473
RPS23 ribosomal protein S23 -0.0216729
RPL8 ribosomal protein L8 -0.0216027
DCT dopachrome tautomerase -0.0215684
PTCHD4 patched domain containing 4 -0.0211775
CAVIN1 caveolae associated protein 1 -0.0211439
HBP1 HMG-box transcription factor 1 -0.0211385
RACK1 receptor for activated C kinase 1 -0.0208311
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0207161
RPS15 ribosomal protein S15 -0.0203798
ANXA2 annexin A2 -0.0202743
DSTN destrin (actin depolymerizing factor) -0.020154
RPS14 ribosomal protein S14 -0.0200937
HSPB1 heat shock 27kDa protein 1 -0.020014
INPP5F inositol polyphosphate-5-phosphatase F -0.0200137