c-Kit-IN-1_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.235342
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.130026
DTNA dystrobrevin, alpha 0.118037
HSPA8 heat shock 70kDa protein 8 0.10928
MYH9 myosin, heavy chain 9, non-muscle 0.0838538
SAMD4A sterile alpha motif domain containing 4A 0.0732942
MCL1 myeloid cell leukemia 1 0.0709907
APP amyloid beta (A4) precursor protein 0.069812
TGM2 transglutaminase 2 0.0609778
SPAG9 sperm associated antigen 9 0.0591454
ARHGAP26 Rho GTPase activating protein 26 0.0584339
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0579576
HSPH1 heat shock 105kDa/110kDa protein 1 0.0576458
SMAD3 SMAD family member 3 0.0556902
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0544478
FNDC3B fibronectin type III domain containing 3B 0.0529711
PGK1 phosphoglycerate kinase 1 0.0526779
PLEC plectin 0.0525678
HOOK2 hook microtubule-tethering protein 2 0.0525606
TFRC transferrin receptor 0.052264
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0519703
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0509573
ASPH aspartate beta-hydroxylase 0.0498332
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0491276
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0487418
JUN jun proto-oncogene 0.0478968
ZSWIM6 zinc finger, SWIM-type containing 6 0.0464814
MACF1 microtubule-actin crosslinking factor 1 0.0463628
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0458206
DST dystonin 0.0453238
UBA6 ubiquitin-like modifier activating enzyme 6 0.0441679
GRB10 growth factor receptor-bound protein 10 0.0438413
APOL1 apolipoprotein L, 1 0.0412519
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0411908
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0411093
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0403912
APLP2 amyloid beta (A4) precursor-like protein 2 0.0397629
HSPA1A heat shock 70kDa protein 1A 0.0389627
ATP13A3 ATPase type 13A3 0.0380263
TRIO trio Rho guanine nucleotide exchange factor 0.0371278
NUP58 nucleoporin 58 0.0369515
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0366931
ZFAND3 zinc finger, AN1-type domain 3 0.0362866
RNF213 ring finger protein 213 0.035929
NAMPT nicotinamide phosphoribosyltransferase 0.0357167
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0349914
PPARD peroxisome proliferator-activated receptor delta 0.0346291
PDIA6 protein disulfide isomerase family A, member 6 0.034075
KIAA1217 KIAA1217 0.0338506
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0337759
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.03375
NPTN neuroplastin 0.0337106
SFPQ splicing factor proline/glutamine-rich 0.0335946
HSPA1B heat shock 70kDa protein 1B 0.0332948
TXNRD1 thioredoxin reductase 1 0.032914
RUNX1 runt-related transcription factor 1 0.0322988
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0322641
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0315214
ERRFI1 ERBB receptor feedback inhibitor 1 0.0313581
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0301606
GARS1 glycyl-tRNA synthetase 1 0.0299132
VEGFA vascular endothelial growth factor A 0.0296748
STRN3 striatin, calmodulin binding protein 3 0.0296538
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.029567
DIAPH1 diaphanous-related formin 1 0.0294133
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0293196
PTK2 protein tyrosine kinase 2 0.0292529
BRD2 bromodomain containing 2 0.0290411
EIF4A2 eukaryotic translation initiation factor 4A2 0.028978
ADAM9 ADAM metallopeptidase domain 9 0.0289272
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.02884
DDIT4 DNA-damage-inducible transcript 4 0.028445
CHD1 chromodomain helicase DNA binding protein 1 0.0278691
EEF2 eukaryotic translation elongation factor 2 0.0267862
RYBP RING1 and YY1 binding protein 0.0267834
TPM3 tropomyosin 3 0.0264526
LPP LIM domain containing preferred translocation partner in lipoma 0.0260711
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.025911
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0257147
LAMC2 laminin, gamma 2 0.0256659
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0254934
EXT1 exostosin glycosyltransferase 1 0.0252052
PAPOLA poly(A) polymerase alpha 0.0248008
SRRM2 serine/arginine repetitive matrix 2 0.0247443
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0247361
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0246117
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0242386
CCNY cyclin Y 0.0241956
MYO1B myosin IB 0.0239102
RIPK4 receptor-interacting serine-threonine kinase 4 0.0238964
ACTN1 actinin, alpha 1 0.0238593
FOSL1 FOS-like antigen 1 0.0238143
HPCAL1 hippocalcin-like 1 0.0235019
CORO1C coronin, actin binding protein, 1C 0.0234297
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0231431
RAB10 RAB10, member RAS oncogene family 0.0228862
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0228153
RCOR1 REST corepressor 1 0.0227199
SGMS2 sphingomyelin synthase 2 0.022619
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0225

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.222894
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.221051
TMSB10 thymosin beta 10 -0.171809
PTMA prothymosin, alpha -0.123877
FTL ferritin, light polypeptide -0.0985879
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0975855
EIF1 eukaryotic translation initiation factor 1 -0.0923089
MT1X metallothionein 1X -0.0817663
RPS8 ribosomal protein S8 -0.0677705
RPLP1 ribosomal protein, large, P1 -0.067236
HLA-B major histocompatibility complex, class I, B -0.0668663
VIM vimentin -0.0644854
ISG15 ISG15 ubiquitin-like modifier -0.061325
TPT1 tumor protein, translationally-controlled 1 -0.0602943
C15ORF48 chromosome 15 open reading frame 48 -0.0600849
B2M beta-2-microglobulin -0.0599709
FTH1 ferritin, heavy polypeptide 1 -0.0598707
RPL35A ribosomal protein L35a -0.0561254
RPS6 ribosomal protein S6 -0.0545106
RPL19 ribosomal protein L19 -0.0524975
ACTG1 actin gamma 1 -0.0494083
KRT19 keratin 19, type I -0.0489536
IFI27 interferon, alpha-inducible protein 27 -0.0471102
S100A6 S100 calcium binding protein A6 -0.0454482
RPS29 ribosomal protein S29 -0.0454065
KDM5B lysine (K)-specific demethylase 5B -0.040978
RPL11 ribosomal protein L11 -0.0399475
RPS19 ribosomal protein S19 -0.0399108
AKAP9 A kinase (PRKA) anchor protein 9 -0.0398904
RPLP0 ribosomal protein, large, P0 -0.0398142
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.03962
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0394425
RPS3 ribosomal protein S3 -0.0384392
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0383698
KLF6 Kruppel-like factor 6 -0.0380678
RPL34 ribosomal protein L34 -0.0379453
MT1E metallothionein 1E -0.0369308
S100A10 S100 calcium binding protein A10 -0.0368839
S100A9 S100 calcium binding protein A9 -0.0363769
RPL23 ribosomal protein L23 -0.0359501
RPS21 ribosomal protein S21 -0.0351054
OGA O-GlcNAcase -0.0350909
RPS23 ribosomal protein S23 -0.0348499
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0338915
POTEF POTE ankyrin domain family, member F -0.0336051
GCC2 GRIP and coiled-coil domain containing 2 -0.0331813
UBE2B ubiquitin-conjugating enzyme E2B -0.0329203
HMGA1 high mobility group AT-hook 1 -0.0325913
TMSB4X thymosin beta 4, X-linked -0.0318483
PLAU plasminogen activator, urokinase -0.0317091
CD2AP CD2-associated protein -0.0314856
IFITM1 interferon induced transmembrane protein 1 -0.0311751
JUP junction plakoglobin -0.0310024
TM4SF1 transmembrane 4 L six family member 1 -0.0306477
RBM39 RNA binding motif protein 39 -0.0306377
RPS14 ribosomal protein S14 -0.030576
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0298572
MMP7 matrix metallopeptidase 7 -0.0298232
IGFBP3 insulin-like growth factor binding protein 3 -0.0296782
RPL9 ribosomal protein L9 -0.0293813
RPS24 ribosomal protein S24 -0.0291567
RPL31 ribosomal protein L31 -0.0291328
CSTB cystatin B (stefin B) -0.0284374
LAMB3 laminin, beta 3 -0.0282728
RPS27A ribosomal protein S27a -0.0278863
PLAUR plasminogen activator, urokinase receptor -0.0276434
RPL12 ribosomal protein L12 -0.0276254
NEK7 NIMA-related kinase 7 -0.0275647
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0272743
G0S2 G0/G1 switch 2 -0.0266099
NT5C2 5'-nucleotidase, cytosolic II -0.0264705
RIOK3 RIO kinase 3 -0.0264565
GNAS GNAS complex locus -0.026413
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0263875
RPS27 ribosomal protein S27 -0.0263066
UGCG UDP-glucose ceramide glucosyltransferase -0.0262265
TXNIP thioredoxin interacting protein -0.0259179
RPLP2 ribosomal protein, large, P2 -0.0252172
WSB1 WD repeat and SOCS box containing 1 -0.0247319
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0246889
IFITM3 interferon induced transmembrane protein 3 -0.024669
PHF3 PHD finger protein 3 -0.0244102
ARID4B AT rich interactive domain 4B (RBP1-like) -0.024209
LY6E lymphocyte antigen 6 complex, locus E -0.0239548
S100A11 S100 calcium binding protein A11 -0.0239323
RPL28 ribosomal protein L28 -0.0238317
RPL8 ribosomal protein L8 -0.0237631
RPL37A ribosomal protein L37a -0.0233379
CTNND1 catenin (cadherin-associated protein), delta 1 -0.023144
SLC38A1 solute carrier family 38, member 1 -0.0228122
IFI6 interferon, alpha-inducible protein 6 -0.0228056
RPL36AL ribosomal protein L36a-like -0.022526
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0224762
CCNI cyclin I -0.0224719
TMEM263 transmembrane protein 263 -0.0224062
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0223231
NPEPPS aminopeptidase puromycin sensitive -0.0222439
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0220017
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0219167
RPS5 ribosomal protein S5 -0.021886