c-Kit-IN-1_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.20923
BTBD9 BTB (POZ) domain containing 9 0.108399
GCLC glutamate-cysteine ligase, catalytic subunit 0.104226
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0965512
GMDS GDP-mannose 4,6-dehydratase 0.0930166
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.08614
MSI2 musashi RNA-binding protein 2 0.0825237
EXT1 exostosin glycosyltransferase 1 0.0783986
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0718055
TRIO trio Rho guanine nucleotide exchange factor 0.0709607
ZNRF3 zinc and ring finger 3 0.0671115
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0657048
FNDC3B fibronectin type III domain containing 3B 0.0643425
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0639269
ANKRD10 ankyrin repeat domain 10 0.0639176
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0637404
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0627243
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0603956
ASPH aspartate beta-hydroxylase 0.0596783
FNDC3A fibronectin type III domain containing 3A 0.0593054
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0572561
APP amyloid beta (A4) precursor protein 0.0569215
NKD1 naked cuticle homolog 1 (Drosophila) 0.0549301
ZNF292 zinc finger protein 292 0.0526623
MCTP1 multiple C2 domains, transmembrane 1 0.0526114
MYH9 myosin, heavy chain 9, non-muscle 0.0500967
TXNRD1 thioredoxin reductase 1 0.0497233
AKAP13 A kinase (PRKA) anchor protein 13 0.0491557
FHIT fragile histidine triad 0.0471217
PADI1 peptidyl arginine deiminase, type I 0.0462736
NUP58 nucleoporin 58 0.0459244
INTS6 integrator complex subunit 6 0.0458833
RUNX1 runt-related transcription factor 1 0.0446432
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0444033
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0439154
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0433357
RBM26 RNA binding motif protein 26 0.0433217
SAMD4A sterile alpha motif domain containing 4A 0.0427978
RAB7A RAB7A, member RAS oncogene family 0.0426343
PATJ PATJ crumbs cell polarity complex component 0.0424961
IARS1 isoleucyl-tRNA synthetase 1 0.0423303
RAD51B RAD51 paralog B 0.0419872
FNIP1 folliculin interacting protein 1 0.041976
FRMD5 FERM domain containing 5 0.0415345
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0412464
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0406129
CANX calnexin 0.0403955
SMAD3 SMAD family member 3 0.0403696
IGF2R insulin-like growth factor 2 receptor 0.0401831
TNNC1 troponin C type 1 (slow) 0.0398753
NF1 neurofibromin 1 0.0394892
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.039423
GARS1 glycyl-tRNA synthetase 1 0.0393009
ZMYM2 zinc finger, MYM-type 2 0.0389128
AHI1 Abelson helper integration site 1 0.0385879
MYO10 myosin X 0.0385222
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0383024
PDZD8 PDZ domain containing 8 0.0372554
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0359997
LPP LIM domain containing preferred translocation partner in lipoma 0.0358469
ANXA2 annexin A2 0.0346794
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0346422
ANKRD17 ankyrin repeat domain 17 0.0344427
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0340807
ANKRD11 ankyrin repeat domain 11 0.0340086
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0339953
NPAS2 neuronal PAS domain protein 2 0.0329422
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.032718
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0326207
HKDC1 hexokinase domain containing 1 0.0324973
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.032094
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0320156
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0320097
SND1 staphylococcal nuclease and tudor domain containing 1 0.0318109
ATXN1 ataxin 1 0.0317775
GSK3B glycogen synthase kinase 3 beta 0.0317668
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0316527
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0312817
BACE2 beta-site APP-cleaving enzyme 2 0.0309466
HSPH1 heat shock 105kDa/110kDa protein 1 0.0309434
CLTC clathrin, heavy chain (Hc) 0.0305915
TFRC transferrin receptor 0.0305899
PLIN2 perilipin 2 0.0302329
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0301859
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0299499
GRK3 G protein-coupled receptor kinase 3 0.029581
DST dystonin 0.0295133
ZFAND3 zinc finger, AN1-type domain 3 0.0295133
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0294069
TOP1 topoisomerase (DNA) I 0.0291771
RAB10 RAB10, member RAS oncogene family 0.0286104
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0285896
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0285682
WDR43 WD repeat domain 43 0.0284118
STK39 serine threonine kinase 39 0.0284005
HOOK2 hook microtubule-tethering protein 2 0.028318
LHFPL2 lipoma HMGIC fusion partner-like 2 0.028227
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0281843
HDAC4 histone deacetylase 4 0.0280752
WWC1 WW and C2 domain containing 1 0.0279712

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.204457
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.157723
ZMYND8 zinc finger, MYND-type containing 8 -0.111953
TPT1 tumor protein, translationally-controlled 1 -0.105882
LCN2 lipocalin 2 -0.0968969
HLA-B major histocompatibility complex, class I, B -0.0875959
IFI6 interferon, alpha-inducible protein 6 -0.0874958
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0793353
PERP PERP, TP53 apoptosis effector -0.0790202
ZBTB20 zinc finger and BTB domain containing 20 -0.0738146
PTMA prothymosin, alpha -0.07037
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0690112
C6ORF132 chromosome 6 open reading frame 132 -0.0674425
FTL ferritin, light polypeptide -0.0659346
EGR1 early growth response 1 -0.0622124
TXNIP thioredoxin interacting protein -0.0612478
AKAP9 A kinase (PRKA) anchor protein 9 -0.0565823
RPS6 ribosomal protein S6 -0.0560624
LOC102724023 ES1 protein homolog, mitochondrial -0.0539202
GCC2 GRIP and coiled-coil domain containing 2 -0.0537603
MT2A metallothionein 2A -0.0534522
TMSB10 thymosin beta 10 -0.0521397
IFI27 interferon, alpha-inducible protein 27 -0.0490342
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0474195
RPLP1 ribosomal protein, large, P1 -0.0474062
EZR ezrin -0.0472983
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0472792
RPL35A ribosomal protein L35a -0.0457415
MX2 MX dynamin-like GTPase 2 -0.0434475
KLHL24 kelch-like family member 24 -0.0423934
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0375534
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0363454
FTH1 ferritin, heavy polypeptide 1 -0.0362793
SP100 SP100 nuclear antigen -0.0359393
S100A10 S100 calcium binding protein A10 -0.0358393
CST3 cystatin C -0.0348276
DSTN destrin (actin depolymerizing factor) -0.0322987
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0322809
UBE2B ubiquitin-conjugating enzyme E2B -0.0322806
RPL19 ribosomal protein L19 -0.0322355
NDRG1 N-myc downstream regulated 1 -0.0314743
EPSTI1 epithelial stromal interaction 1 (breast) -0.0314737
S100A6 S100 calcium binding protein A6 -0.0314408
RNF149 ring finger protein 149 -0.0314326
KRT19 keratin 19, type I -0.0310635
EIF1 eukaryotic translation initiation factor 1 -0.0310604
TMPRSS4 transmembrane protease, serine 4 -0.030901
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0307
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0306914
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0306351
PKM pyruvate kinase, muscle -0.030471
LIMA1 LIM domain and actin binding 1 -0.0302679
H3-3B H3.3 histone B -0.0301364
RPS27 ribosomal protein S27 -0.0299532
MPHOSPH8 M-phase phosphoprotein 8 -0.0298982
IFITM3 interferon induced transmembrane protein 3 -0.0298757
NUCB2 nucleobindin 2 -0.0296857
RPS8 ribosomal protein S8 -0.0296063
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0293073
UBC ubiquitin C -0.0290456
TPI1 triosephosphate isomerase 1 -0.0285229
CLDN4 claudin 4 -0.0282421
RPS19 ribosomal protein S19 -0.0281905
RPLP2 ribosomal protein, large, P2 -0.0279237
RPL23 ribosomal protein L23 -0.0279122
RPL31 ribosomal protein L31 -0.0276634
GOLGB1 golgin B1 -0.0276234
PTBP3 polypyrimidine tract binding protein 3 -0.0273303
IRF1 interferon regulatory factor 1 -0.0270062
RB1CC1 RB1-inducible coiled-coil 1 -0.0269523
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0269449
RPS29 ribosomal protein S29 -0.0266457
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0266258
HLA-A major histocompatibility complex, class I, A -0.0264822
HLA-C major histocompatibility complex, class I, C -0.0262828
HLA-E major histocompatibility complex, class I, E -0.0261317
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0259551
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0255616
DIAPH3 diaphanous-related formin 3 -0.0254283
ACBD3 acyl-CoA binding domain containing 3 -0.0251895
NBR1 neighbor of BRCA1 gene 1 -0.0251528
WASF2 WAS protein family, member 2 -0.0246398
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0242186
RPL34 ribosomal protein L34 -0.0241075
WSB1 WD repeat and SOCS box containing 1 -0.0237157
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0236942
GNAS GNAS complex locus -0.0236227
NCKAP5 NCK-associated protein 5 -0.0235931
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0233407
POTEF POTE ankyrin domain family, member F -0.0233061
SPINT1 serine peptidase inhibitor, Kunitz type 1 -0.0227592
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0227499
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0225531
SMIM14 small integral membrane protein 14 -0.0224288
KLF6 Kruppel-like factor 6 -0.0223149
TM4SF1 transmembrane 4 L six family member 1 -0.0221744
PMP22 peripheral myelin protein 22 -0.0219814
GOLPH3L golgi phosphoprotein 3-like -0.0219261
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0218292
RPS23 ribosomal protein S23 -0.0217254