c-Kit-IN-1_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.204726
CXCL8 chemokine (C-X-C motif) ligand 8 0.155929
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.101163
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0937907
NDRG1 N-myc downstream regulated 1 0.0933478
ANK2 ankyrin 2, neuronal 0.0911889
NAMPT nicotinamide phosphoribosyltransferase 0.081311
HOOK2 hook microtubule-tethering protein 2 0.0749272
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0696952
FAM13A family with sequence similarity 13, member A 0.0643269
ASPH aspartate beta-hydroxylase 0.0640097
ZFAND3 zinc finger, AN1-type domain 3 0.0633205
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0576336
GARS1 glycyl-tRNA synthetase 1 0.056791
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0566608
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0558587
CLTC clathrin, heavy chain (Hc) 0.0527981
CREB5 cAMP responsive element binding protein 5 0.0526396
COG5 component of oligomeric golgi complex 5 0.0526253
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0515251
FAM219A family with sequence similarity 219, member A 0.0500923
FNIP1 folliculin interacting protein 1 0.0492354
NUP58 nucleoporin 58 0.0482478
LDHA lactate dehydrogenase A 0.048045
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0430383
ATP13A3 ATPase type 13A3 0.0428117
HELZ helicase with zinc finger 0.0420092
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0410138
TRA2A transformer 2 alpha homolog (Drosophila) 0.0398878
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0397615
BACE2 beta-site APP-cleaving enzyme 2 0.0390336
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.03894
UBA6 ubiquitin-like modifier activating enzyme 6 0.0389127
SPAG9 sperm associated antigen 9 0.0386593
GOLGA4 golgin A4 0.0382779
NBAS neuroblastoma amplified sequence 0.0380856
DLG1 discs, large homolog 1 (Drosophila) 0.037958
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0379566
DTNA dystrobrevin, alpha 0.0377135
DGKD diacylglycerol kinase, delta 130kDa 0.0376422
TXNRD1 thioredoxin reductase 1 0.0371247
SDK1 sidekick cell adhesion molecule 1 0.036862
YEATS2 YEATS domain containing 2 0.0359087
COL5A1 collagen, type V, alpha 1 0.0354941
COPA coatomer protein complex, subunit alpha 0.0354237
CANX calnexin 0.0344444
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0343293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0339769
ZNF638 zinc finger protein 638 0.0330565
FNDC3B fibronectin type III domain containing 3B 0.0328892
MAP1B microtubule-associated protein 1B 0.0325685
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0323075
PGK1 phosphoglycerate kinase 1 0.0319123
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0313865
SND1 staphylococcal nuclease and tudor domain containing 1 0.0311235
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0309988
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.030738
FAT1 FAT atypical cadherin 1 0.0307377
KMT2C lysine (K)-specific methyltransferase 2C 0.0306874
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0297877
ZNF841 zinc finger protein 841 0.0296498
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0296255
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0293936
SEC23A Sec23 homolog A (S. cerevisiae) 0.0291475
ZFC3H1 zinc finger, C3H1-type containing 0.0290159
USP34 ubiquitin specific peptidase 34 0.0289118
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0285077
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0283243
ELL2 elongation factor, RNA polymerase II, 2 0.027742
SEC24A SEC24 family member A 0.0274951
MAP2K1 mitogen-activated protein kinase kinase 1 0.0274852
PRELID2 PRELI domain containing 2 0.0274688
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0274061
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0273764
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0271751
WDR45B WD repeat domain 45B 0.0270825
PIAS2 protein inhibitor of activated STAT, 2 0.0268419
RAB1A RAB1A, member RAS oncogene family 0.0262362
JARID2 jumonji, AT rich interactive domain 2 0.0262317
CDK13 cyclin-dependent kinase 13 0.0257971
SEC31A SEC31 homolog A (S. cerevisiae) 0.0255385
CLINT1 clathrin interactor 1 0.0254291
PRKCE protein kinase C, epsilon 0.0254088
GSK3B glycogen synthase kinase 3 beta 0.025356
MORF4L2 mortality factor 4 like 2 0.0253384
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0252398
SRP54 signal recognition particle 54kDa 0.0251598
TMEM39A transmembrane protein 39A 0.025129
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0251037
SUCO SUN domain containing ossification factor 0.0248674
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0248399
TRIO trio Rho guanine nucleotide exchange factor 0.0247249
PTPRD protein tyrosine phosphatase, receptor type, D 0.0246659
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0246255
RUNX1 runt-related transcription factor 1 0.0244739
MYH9 myosin, heavy chain 9, non-muscle 0.0244279
SNX13 sorting nexin 13 0.0243177
LOC112694756 uncharaterized LOC112694756 0.0240822
PICALM phosphatidylinositol binding clathrin assembly protein 0.0240146
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0239265

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.106027
MT2A metallothionein 2A -0.102333
FTL ferritin, light polypeptide -0.0942635
PTMA prothymosin, alpha -0.0913235
VIM vimentin -0.084629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0834322
TPM4 tropomyosin 4 -0.0760543
RPS13 ribosomal protein S13 -0.0691334
TMSB10 thymosin beta 10 -0.0684511
RPS8 ribosomal protein S8 -0.0678281
FN1 fibronectin 1 -0.0658223
RPL37A ribosomal protein L37a -0.0645711
RPS3 ribosomal protein S3 -0.0585507
AHNAK AHNAK nucleoprotein -0.0578688
HLA-B major histocompatibility complex, class I, B -0.0572334
INHBA inhibin, beta A -0.0562976
RPLP2 ribosomal protein, large, P2 -0.0559822
TPT1 tumor protein, translationally-controlled 1 -0.0548024
EGFR epidermal growth factor receptor -0.0542858
RPL31 ribosomal protein L31 -0.053197
RPLP1 ribosomal protein, large, P1 -0.0523816
RPL12 ribosomal protein L12 -0.0521708
RPS27A ribosomal protein S27a -0.0509798
B2M beta-2-microglobulin -0.0472042
HLA-A major histocompatibility complex, class I, A -0.0462954
RPL23 ribosomal protein L23 -0.0455096
RPL35A ribosomal protein L35a -0.0447154
RPL9 ribosomal protein L9 -0.0440957
RPL13A ribosomal protein L13a -0.0436884
RPL11 ribosomal protein L11 -0.0435013
TGFBI transforming growth factor, beta-induced, 68kDa -0.0426991
RPL28 ribosomal protein L28 -0.0426518
NALF1 NALCN channel auxiliary factor 1 -0.0423286
RPS12 ribosomal protein S12 -0.0419892
RACK1 receptor for activated C kinase 1 -0.0408779
LOX lysyl oxidase -0.0402663
RPS25 ribosomal protein S25 -0.0400008
RPS17 ribosomal protein S17 -0.0394257
ACTG1 actin gamma 1 -0.0389002
RPL19 ribosomal protein L19 -0.0381949
TNS3 tensin 3 -0.0377367
ANXA2 annexin A2 -0.0370057
RPS19 ribosomal protein S19 -0.0356123
AKAP12 A kinase (PRKA) anchor protein 12 -0.0354871
RPL37 ribosomal protein L37 -0.0345745
RPL36 ribosomal protein L36 -0.0341448
CD44 CD44 molecule (Indian blood group) -0.0322279
RPS23 ribosomal protein S23 -0.0318402
RPS14 ribosomal protein S14 -0.0314366
FTH1 ferritin, heavy polypeptide 1 -0.0311832
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0306628
RPS5 ribosomal protein S5 -0.0305565
RPL38 ribosomal protein L38 -0.030239
RPL27A ribosomal protein L27a -0.0289059
PSD3 pleckstrin and Sec7 domain containing 3 -0.0284584
RPL34 ribosomal protein L34 -0.0280427
RPS16 ribosomal protein S16 -0.0279725
IGFBP3 insulin-like growth factor binding protein 3 -0.027124
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0265575
RPS11 ribosomal protein S11 -0.0264969
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0264716
RPS27 ribosomal protein S27 -0.0261632
CAVIN1 caveolae associated protein 1 -0.0260032
HLA-C major histocompatibility complex, class I, C -0.0259235
RPL8 ribosomal protein L8 -0.0258242
RPL18 ribosomal protein L18 -0.0257174
RPS29 ribosomal protein S29 -0.0253046
TIMP3 TIMP metallopeptidase inhibitor 3 -0.025275
RAI14 retinoic acid induced 14 -0.0250646
FAM20C family with sequence similarity 20, member C -0.0242318
RPL22L1 ribosomal protein L22-like 1 -0.0239933
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0232178
IGF2 insulin-like growth factor 2 -0.0231381
RPS10 ribosomal protein S10 -0.0231068
RRBP1 ribosome binding protein 1 -0.0229851
RPS2 ribosomal protein S2 -0.0229349
ZMYND8 zinc finger, MYND-type containing 8 -0.0229232
S100A6 S100 calcium binding protein A6 -0.0229166
RPL7A ribosomal protein L7a -0.0225252
RPL32 ribosomal protein L32 -0.0225197
RPS20 ribosomal protein S20 -0.0216616
GLIS3 GLIS family zinc finger 3 -0.0216113
RPS21 ribosomal protein S21 -0.0210492
SDC4 syndecan 4 -0.0209135
SP100 SP100 nuclear antigen -0.0208698
NAV1 neuron navigator 1 -0.0208512
PLAUR plasminogen activator, urokinase receptor -0.0206494
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0203057
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0200104
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0198124
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0196986
LAMB3 laminin, beta 3 -0.0196977
SBF2 SET binding factor 2 -0.0193969
KMT2A lysine (K)-specific methyltransferase 2A -0.0191716
CD63 CD63 molecule -0.0191078
RPL27 ribosomal protein L27 -0.0191046
MYO10 myosin X -0.0190582
LYPD6B LY6/PLAUR domain containing 6B -0.0189531
RPL5 ribosomal protein L5 -0.0187608
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0186397