c-Kit-IN-1_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.309216
EEF2 eukaryotic translation elongation factor 2 0.117562
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.116912
P4HB prolyl 4-hydroxylase, beta polypeptide 0.112389
NUP58 nucleoporin 58 0.0826694
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.076873
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0749352
GARS1 glycyl-tRNA synthetase 1 0.0699235
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0651626
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0649217
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0646278
GOLGA4 golgin A4 0.0639214
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0558296
PCBP2 poly(rC) binding protein 2 0.0496333
ZFAND3 zinc finger, AN1-type domain 3 0.0495052
TTC3 tetratricopeptide repeat domain 3 0.0482481
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0480331
VEGFA vascular endothelial growth factor A 0.0459333
ANKRD11 ankyrin repeat domain 11 0.0459264
MYH9 myosin, heavy chain 9, non-muscle 0.0457381
SRRM2 serine/arginine repetitive matrix 2 0.0452965
HOOK2 hook microtubule-tethering protein 2 0.0449789
TFRC transferrin receptor 0.0445836
INTS6 integrator complex subunit 6 0.0443418
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0435217
RUNX1 runt-related transcription factor 1 0.0431735
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0430474
ANK2 ankyrin 2, neuronal 0.0422738
LDHA lactate dehydrogenase A 0.0396264
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0394008
ZNF638 zinc finger protein 638 0.0390819
DDIT4 DNA-damage-inducible transcript 4 0.0387958
PRELID2 PRELI domain containing 2 0.0384182
ARFGEF3 ARFGEF family member 3 0.0373374
RPL3 ribosomal protein L3 0.0370269
FNIP1 folliculin interacting protein 1 0.0367162
PRRC2C proline-rich coiled-coil 2C 0.036515
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0360963
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0357934
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0352184
SFPQ splicing factor proline/glutamine-rich 0.0347531
LOC112694756 uncharaterized LOC112694756 0.0347487
GPHN gephyrin 0.0346189
SMYD3 SET and MYND domain containing 3 0.0345255
HSPA8 heat shock 70kDa protein 8 0.0343779
COG5 component of oligomeric golgi complex 5 0.0332253
PABPC1 poly(A) binding protein, cytoplasmic 1 0.033207
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0331207
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0331203
RAB6A RAB6A, member RAS oncogene family 0.0330992
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0329959
XPOT exportin, tRNA 0.0323914
ENO2 enolase 2 (gamma, neuronal) 0.0323537
COG6 component of oligomeric golgi complex 6 0.0313805
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0307438
CLIC4 chloride intracellular channel 4 0.0306174
UBA6 ubiquitin-like modifier activating enzyme 6 0.0305524
TMF1 TATA element modulatory factor 1 0.0304221
SND1 staphylococcal nuclease and tudor domain containing 1 0.0304089
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0304033
YEATS2 YEATS domain containing 2 0.0303607
CHRM3 cholinergic receptor, muscarinic 3 0.0303032
PSAT1 phosphoserine aminotransferase 1 0.0302387
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0299402
NAMPT nicotinamide phosphoribosyltransferase 0.0295428
RAB7A RAB7A, member RAS oncogene family 0.0291627
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0290191
CCNL1 cyclin L1 0.0288038
SEC24A SEC24 family member A 0.0284863
NBAS neuroblastoma amplified sequence 0.028454
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0279064
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0276275
CEMIP2 cell migration inducing hyaluronidase 2 0.0274932
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0274849
OLA1 Obg-like ATPase 1 0.0273966
IARS1 isoleucyl-tRNA synthetase 1 0.0273525
YARS1 tyrosyl-tRNA synthetase 1 0.0272944
APLP2 amyloid beta (A4) precursor-like protein 2 0.0272885
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0272696
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0272162
PTPRG protein tyrosine phosphatase, receptor type, G 0.026549
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0260977
BRD2 bromodomain containing 2 0.0257877
RYBP RING1 and YY1 binding protein 0.0254543
MAP2K1 mitogen-activated protein kinase kinase 1 0.025433
GRB10 growth factor receptor-bound protein 10 0.0253746
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0252262
HELZ helicase with zinc finger 0.0251793
BIRC6 baculoviral IAP repeat containing 6 0.0249515
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.024929
EIF5 eukaryotic translation initiation factor 5 0.024662
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0245806
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.024366
FRAS1 Fraser extracellular matrix complex subunit 1 0.0243171
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0242655
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0239885
MYO1B myosin IB 0.0238245
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0236487
CCNH cyclin H 0.0235889
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.023587

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.232647
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173259
AHNAK AHNAK nucleoprotein -0.165776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.157874
FAT1 FAT atypical cadherin 1 -0.156789
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.151117
TPT1 tumor protein, translationally-controlled 1 -0.121223
TMSB10 thymosin beta 10 -0.118245
TPM4 tropomyosin 4 -0.0808826
EZR ezrin -0.0727763
MED13L mediator complex subunit 13-like -0.0630077
RPS6 ribosomal protein S6 -0.0589611
KRT18 keratin 18, type I -0.0581832
RPS8 ribosomal protein S8 -0.0564537
RPLP0 ribosomal protein, large, P0 -0.0562916
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0544998
KRT19 keratin 19, type I -0.0527246
RAD21 RAD21 homolog (S. pombe) -0.049114
PKM pyruvate kinase, muscle -0.0481664
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0481051
RPL35A ribosomal protein L35a -0.0480202
S100A10 S100 calcium binding protein A10 -0.0478873
MKI67 marker of proliferation Ki-67 -0.0475389
KRT8 keratin 8, type II -0.0464681
MT2A metallothionein 2A -0.0464148
AKAP9 A kinase (PRKA) anchor protein 9 -0.0460646
TNRC6B trinucleotide repeat containing 6B -0.045835
ANXA2 annexin A2 -0.0455349
ACTG1 actin gamma 1 -0.0453506
RPS24 ribosomal protein S24 -0.0417361
VCL vinculin -0.0416901
OGA O-GlcNAcase -0.0404748
S100A9 S100 calcium binding protein A9 -0.040408
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0401494
HMGB2 high mobility group box 2 -0.0399349
MBD5 methyl-CpG binding domain protein 5 -0.039854
SDC4 syndecan 4 -0.0396457
RPLP1 ribosomal protein, large, P1 -0.0386836
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0384745
RPL34 ribosomal protein L34 -0.0376567
ZBTB20 zinc finger and BTB domain containing 20 -0.0372525
RAD51B RAD51 paralog B -0.0369221
CENPF centromere protein F, 350/400kDa -0.0369204
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0365282
RB1CC1 RB1-inducible coiled-coil 1 -0.0361641
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0355285
RRBP1 ribosome binding protein 1 -0.0354343
KLF6 Kruppel-like factor 6 -0.0354005
RPL26 ribosomal protein L26 -0.0352162
RPLP2 ribosomal protein, large, P2 -0.0348089
HMGA1 high mobility group AT-hook 1 -0.0344111
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0340349
RPS21 ribosomal protein S21 -0.0339855
RPL11 ribosomal protein L11 -0.0335029
CD2AP CD2-associated protein -0.0334769
PERP PERP, TP53 apoptosis effector -0.0333446
MYOF myoferlin -0.0332508
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.032895
HMGB1 high mobility group box 1 -0.0326911
PLAUR plasminogen activator, urokinase receptor -0.0326858
RPS27A ribosomal protein S27a -0.0325373
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0319028
HBP1 HMG-box transcription factor 1 -0.0316553
CCND1 cyclin D1 -0.0310505
EGFR epidermal growth factor receptor -0.0308333
EPCAM epithelial cell adhesion molecule -0.0307162
PHF3 PHD finger protein 3 -0.0305689
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0303585
SLC38A2 solute carrier family 38, member 2 -0.0301464
S100A6 S100 calcium binding protein A6 -0.0294789
RPL8 ribosomal protein L8 -0.0294294
TUBA1B tubulin, alpha 1b -0.0292966
RSF1 remodeling and spacing factor 1 -0.0292538
RAB1A RAB1A, member RAS oncogene family -0.0290886
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0287847
TPI1 triosephosphate isomerase 1 -0.0287181
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0286361
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0285824
TBC1D4 TBC1 domain family, member 4 -0.0283783
GOLGB1 golgin B1 -0.0279693
HOXB3 homeobox B3 -0.027969
RPS15 ribosomal protein S15 -0.0276908
SERINC1 serine incorporator 1 -0.0274377
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0274008
MYL12B myosin, light chain 12B, regulatory -0.0273415
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0266836
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0266508
SHROOM3 shroom family member 3 -0.0264812
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0263422
RBM39 RNA binding motif protein 39 -0.0262826
RPL35 ribosomal protein L35 -0.025908
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.025807
CCNI cyclin I -0.0257719
RPS13 ribosomal protein S13 -0.0256123
TCF12 transcription factor 12 -0.0255987
UBE2B ubiquitin-conjugating enzyme E2B -0.0255824
SBF2 SET binding factor 2 -0.0255138
CIRSR corepressor of RBPJ and splicing regulator -0.0253476
MYO9A myosin IXA -0.0252758
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0251724