c-Kit-IN-1_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.192505
MYH9 myosin, heavy chain 9, non-muscle 0.147816
EEF2 eukaryotic translation elongation factor 2 0.110402
LPP LIM domain containing preferred translocation partner in lipoma 0.107041
FLNA filamin A, alpha 0.0975175
FNDC3B fibronectin type III domain containing 3B 0.0867242
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0866158
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0837821
PAX8 paired box 8 0.0784443
PRELID2 PRELI domain containing 2 0.0749358
PLEC plectin 0.0721194
WWC1 WW and C2 domain containing 1 0.069601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0695012
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0623767
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0619913
APP amyloid beta (A4) precursor protein 0.0595603
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0568263
ZFAND3 zinc finger, AN1-type domain 3 0.0551257
SPAG9 sperm associated antigen 9 0.0529056
BHLHE40 basic helix-loop-helix family, member e40 0.0527691
ANK2 ankyrin 2, neuronal 0.0525013
RUNX1 runt-related transcription factor 1 0.0524919
CREB5 cAMP responsive element binding protein 5 0.0498019
FAT1 FAT atypical cadherin 1 0.0496054
SMYD3 SET and MYND domain containing 3 0.0488906
SMAD3 SMAD family member 3 0.0485652
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0460252
SHB Src homology 2 domain containing adaptor protein B 0.045975
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0456587
SIK3 SIK family kinase 3 0.0451621
IARS1 isoleucyl-tRNA synthetase 1 0.045068
RYBP RING1 and YY1 binding protein 0.0429981
FNIP1 folliculin interacting protein 1 0.0422413
WWOX WW domain containing oxidoreductase 0.041971
TRIO trio Rho guanine nucleotide exchange factor 0.0419631
SRRM2 serine/arginine repetitive matrix 2 0.0411361
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0405649
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0398672
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0396239
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0392968
TUSC3 tumor suppressor candidate 3 0.0392678
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.039261
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0391337
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0385834
GMDS GDP-mannose 4,6-dehydratase 0.0370386
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0358739
AFF4 AF4/FMR2 family, member 4 0.0357381
FHIT fragile histidine triad 0.0354635
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0348971
ANKRD17 ankyrin repeat domain 17 0.034825
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0346624
TFRC transferrin receptor 0.0346354
INTS6 integrator complex subunit 6 0.0344091
HSPA8 heat shock 70kDa protein 8 0.034319
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0341958
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0338398
LOC112694756 uncharaterized LOC112694756 0.033661
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.033267
DENND1A DENN/MADD domain containing 1A 0.0327177
NUP58 nucleoporin 58 0.0319389
GPHN gephyrin 0.0318691
ANKRD11 ankyrin repeat domain 11 0.0312902
CYSTM1 cysteine-rich transmembrane module containing 1 0.0312716
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0310182
ACTN4 actinin, alpha 4 0.030896
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0308348
NF1 neurofibromin 1 0.0303415
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0303355
PTPRG protein tyrosine phosphatase, receptor type, G 0.0302419
GARS1 glycyl-tRNA synthetase 1 0.0301894
SEC24D SEC24 family member D 0.0294717
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0293834
MSI2 musashi RNA-binding protein 2 0.0293221
BIRC3 baculoviral IAP repeat containing 3 0.029158
BIRC6 baculoviral IAP repeat containing 6 0.0291371
EIF4A2 eukaryotic translation initiation factor 4A2 0.0288511
SEC24A SEC24 family member A 0.028707
MACF1 microtubule-actin crosslinking factor 1 0.0286987
NGLY1 N-glycanase 1 0.0284653
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0283575
LINGO2 leucine rich repeat and Ig domain containing 2 0.0280734
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0277607
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0276584
SEC31A SEC31 homolog A (S. cerevisiae) 0.0274338
SEPTIN9 septin 9 0.0270958
TPD52 tumor protein D52 0.027038
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.0269419
IRF1 interferon regulatory factor 1 0.026923
CLTC clathrin, heavy chain (Hc) 0.0268263
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0265985
MPRIP myosin phosphatase Rho interacting protein 0.0264482
ZNF638 zinc finger protein 638 0.0264208
FRAS1 Fraser extracellular matrix complex subunit 1 0.0264159
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0260282
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0260229
KIAA1671 KIAA1671 0.0259898
FAM120A family with sequence similarity 120A 0.0259667
USP9X ubiquitin specific peptidase 9, X-linked 0.0258804
SND1 staphylococcal nuclease and tudor domain containing 1 0.0258586
TBCD tubulin folding cofactor D 0.0258096

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.129425
TMSB10 thymosin beta 10 -0.111416
MT2A metallothionein 2A -0.109813
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0961141
ZBTB20 zinc finger and BTB domain containing 20 -0.0861821
FTL ferritin, light polypeptide -0.0809872
RPS6 ribosomal protein S6 -0.0718129
PTMA prothymosin, alpha -0.071072
TOP2A topoisomerase (DNA) II alpha 170kDa -0.066051
CCND1 cyclin D1 -0.0625103
DLC1 DLC1 Rho GTPase activating protein -0.0604751
B2M beta-2-microglobulin -0.0575843
MKI67 marker of proliferation Ki-67 -0.0525
RHEX regulator of hemoglobinization and erythroid cell expansion -0.0516925
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.046356
GCC2 GRIP and coiled-coil domain containing 2 -0.045364
TMSB4X thymosin beta 4, X-linked -0.0440086
RPS8 ribosomal protein S8 -0.0436149
S100A6 S100 calcium binding protein A6 -0.0434832
ENO1 enolase 1, (alpha) -0.0414679
TPT1 tumor protein, translationally-controlled 1 -0.0401723
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0399504
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0376692
DSG2 desmoglein 2 -0.0375494
ASPH aspartate beta-hydroxylase -0.0374786
TNRC6B trinucleotide repeat containing 6B -0.0363438
IGFBP3 insulin-like growth factor binding protein 3 -0.0359048
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0358552
LIMCH1 LIM and calponin homology domains 1 -0.035412
ARHGAP29 Rho GTPase activating protein 29 -0.0352362
BICD1 bicaudal D homolog 1 (Drosophila) -0.033411
LAMC2 laminin, gamma 2 -0.0322634
AHNAK AHNAK nucleoprotein -0.0321149
PCED1B PC-esterase domain containing 1B -0.0320617
MAML2 mastermind-like 2 (Drosophila) -0.0317843
DSCAML1 Down syndrome cell adhesion molecule like 1 -0.0316677
TPI1 triosephosphate isomerase 1 -0.0308962
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.030845
RPS27A ribosomal protein S27a -0.0306187
CBX3 chromobox homolog 3 -0.0306108
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0305467
RPS19 ribosomal protein S19 -0.0301167
RPS29 ribosomal protein S29 -0.0297658
S100A9 S100 calcium binding protein A9 -0.0292786
RPLP2 ribosomal protein, large, P2 -0.0288514
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0287272
RPL32 ribosomal protein L32 -0.0286104
ZMYND8 zinc finger, MYND-type containing 8 -0.0285708
UBXN4 UBX domain protein 4 -0.0285094
MIS18BP1 MIS18 binding protein 1 -0.028492
SBF2 SET binding factor 2 -0.0282159
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0281277
RPS12 ribosomal protein S12 -0.0281255
RPS2 ribosomal protein S2 -0.0279739
AXL AXL receptor tyrosine kinase -0.0278578
DOCK4 dedicator of cytokinesis 4 -0.0277986
BBX bobby sox homolog (Drosophila) -0.0277522
RPL26 ribosomal protein L26 -0.0276045
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0274757
SLC38A2 solute carrier family 38, member 2 -0.0274545
RPS3 ribosomal protein S3 -0.0272923
ADAM10 ADAM metallopeptidase domain 10 -0.0272349
SEPTIN7 septin 7 -0.026895
FOXP1 forkhead box P1 -0.0266015
ITGA6 integrin, alpha 6 -0.02658
KRT7 keratin 7, type II -0.0264023
SSH2 slingshot protein phosphatase 2 -0.0263416
PKM pyruvate kinase, muscle -0.0262111
RPL38 ribosomal protein L38 -0.02607
PHIP pleckstrin homology domain interacting protein -0.0260041
RPL19 ribosomal protein L19 -0.0259735
RPL9 ribosomal protein L9 -0.0259037
OXR1 oxidation resistance 1 -0.0258732
RPL28 ribosomal protein L28 -0.0258371
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0256811
HMGA1 high mobility group AT-hook 1 -0.0255851
RPL31 ribosomal protein L31 -0.025539
WASF2 WAS protein family, member 2 -0.0254198
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0253092
HMGA2 high mobility group AT-hook 2 -0.0252741
RPLP1 ribosomal protein, large, P1 -0.0252007
PERP PERP, TP53 apoptosis effector -0.0251496
RPL35A ribosomal protein L35a -0.0251064
SCAF11 SR-related CTD-associated factor 11 -0.025103
ALCAM activated leukocyte cell adhesion molecule -0.024755
H3-3B H3.3 histone B -0.0247087
WSB1 WD repeat and SOCS box containing 1 -0.0246604
RAD51B RAD51 paralog B -0.0246023
S100A10 S100 calcium binding protein A10 -0.024395
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0243308
RB1CC1 RB1-inducible coiled-coil 1 -0.0240632
RPL12 ribosomal protein L12 -0.0240248
BRCA1 breast cancer 1, early onset -0.0239474
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0238179
OGA O-GlcNAcase -0.0237083
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0235639
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0233883
POTEF POTE ankyrin domain family, member F -0.0232546
CENPF centromere protein F, 350/400kDa -0.0223528
RPS15 ribosomal protein S15 -0.022192