| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | c-Kit-IN-1 perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the c-Kit-IN-1_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.208783 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.181208 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.173185 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.144229 |
| COL5A1 | collagen, type V, alpha 1 | 0.138809 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.132583 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.120772 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.112216 |
| NDRG1 | N-myc downstream regulated 1 | 0.098569 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0927783 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0900534 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0831822 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0819846 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.081864 |
| SEPTIN9 | septin 9 | 0.0817074 |
| PLEC | plectin | 0.079526 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0781177 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0774714 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0749188 |
| DST | dystonin | 0.0738072 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.070764 |
| VEGFA | vascular endothelial growth factor A | 0.0697655 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0693955 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0692686 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0667904 |
| DTNA | dystrobrevin, alpha | 0.0641322 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0616421 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0608146 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.058933 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0586218 |
| PTK2 | protein tyrosine kinase 2 | 0.0551726 |
| FLNA | filamin A, alpha | 0.0550583 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0510516 |
| ASPH | aspartate beta-hydroxylase | 0.0509476 |
| NAV1 | neuron navigator 1 | 0.050727 |
| TFRC | transferrin receptor | 0.0502459 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0472774 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0470295 |
| FNIP1 | folliculin interacting protein 1 | 0.0467369 |
| INTS6 | integrator complex subunit 6 | 0.046058 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.045666 |
| INHBA | inhibin, beta A | 0.0456122 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0441829 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0438967 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.043593 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0431453 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0431448 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0425695 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0424069 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0422993 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0421204 |
| MT2A | metallothionein 2A | 0.0418974 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0411619 |
| MAP1B | microtubule-associated protein 1B | 0.0409989 |
| FAT1 | FAT atypical cadherin 1 | 0.0409604 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0407156 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0405181 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0390065 |
| PDE10A | phosphodiesterase 10A | 0.0389049 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0389033 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0385363 |
| SFTPA2 | surfactant protein A2 | 0.0381583 |
| RUNX1 | runt-related transcription factor 1 | 0.0381373 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0373325 |
| MYO1B | myosin IB | 0.0371438 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0359832 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0354097 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0348235 |
| APP | amyloid beta (A4) precursor protein | 0.0346482 |
| KIAA1217 | KIAA1217 | 0.0345882 |
| BRD2 | bromodomain containing 2 | 0.0343551 |
| ZNF638 | zinc finger protein 638 | 0.0343462 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0343404 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | 0.0342558 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0341232 |
| NAV3 | neuron navigator 3 | 0.0339396 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0339246 |
| NUP58 | nucleoporin 58 | 0.0338961 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0336473 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.033581 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0334677 |
| FMNL2 | formin-like 2 | 0.0334646 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0334392 |
| FAM219A | family with sequence similarity 219, member A | 0.0328048 |
| LDHA | lactate dehydrogenase A | 0.0322179 |
| PRKCA | protein kinase C, alpha | 0.0316359 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0315576 |
| FAM13A | family with sequence similarity 13, member A | 0.0314363 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0309276 |
| COPA | coatomer protein complex, subunit alpha | 0.0308634 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0307994 |
| HOMER1 | homer scaffolding protein 1 | 0.0306689 |
| TNS1 | tensin 1 | 0.030653 |
| PCBP3 | poly(rC) binding protein 3 | 0.0304123 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0299056 |
| RCOR1 | REST corepressor 1 | 0.029819 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0296924 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0296643 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0292074 |
| IER3 | immediate early response 3 | 0.0288647 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.263082 |
| FN1 | fibronectin 1 | -0.190098 |
| CD44 | CD44 molecule (Indian blood group) | -0.105037 |
| CDH13 | cadherin 13 | -0.077633 |
| IGF2 | insulin-like growth factor 2 | -0.0675804 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0582474 |
| ACTG1 | actin gamma 1 | -0.0578004 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0540705 |
| TMSB10 | thymosin beta 10 | -0.0534077 |
| LAMB3 | laminin, beta 3 | -0.0484862 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0463104 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0449757 |
| RTN4 | reticulon 4 | -0.0442152 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0400892 |
| RRBP1 | ribosome binding protein 1 | -0.0389038 |
| CENPF | centromere protein F, 350/400kDa | -0.0383491 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0381414 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0376002 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0375453 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0353944 |
| TNNC1 | troponin C type 1 (slow) | -0.035025 |
| OGA | O-GlcNAcase | -0.0348763 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.033648 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0332029 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0316003 |
| ETV6 | ets variant 6 | -0.031397 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0307713 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0303551 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.0295035 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0293776 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0286849 |
| SBF2 | SET binding factor 2 | -0.0283327 |
| IL1B | interleukin 1, beta | -0.0277672 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0271685 |
| COL1A1 | collagen, type I, alpha 1 | -0.0268469 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0264718 |
| CCND1 | cyclin D1 | -0.0256599 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0253457 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0251074 |
| RAD21 | RAD21 homolog (S. pombe) | -0.025024 |
| VASP | vasodilator-stimulated phosphoprotein | -0.0247426 |
| CENPE | centromere protein E, 312kDa | -0.0246814 |
| CDCP1 | CUB domain containing protein 1 | -0.0246738 |
| GNAS | GNAS complex locus | -0.0244035 |
| KIF14 | kinesin family member 14 | -0.024218 |
| SGO2 | shugoshin 2 | -0.0234565 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0230953 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.022538 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | -0.0225275 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0222194 |
| RBM39 | RNA binding motif protein 39 | -0.0219058 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0217918 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0213528 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0210385 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0209227 |
| CAVIN1 | caveolae associated protein 1 | -0.0207784 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0199776 |
| ECT2 | epithelial cell transforming 2 | -0.0199619 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0199144 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0195784 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0193836 |
| TENM2 | teneurin transmembrane protein 2 | -0.0193442 |
| CEP95 | centrosomal protein 95kDa | -0.0190483 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | -0.018828 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0188162 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0187267 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | -0.0185808 |
| MYL12B | myosin, light chain 12B, regulatory | -0.018498 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0184729 |
| ALDH1A3 | aldehyde dehydrogenase 1 family, member A3 | -0.0183275 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.018059 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0179565 |
| PRR11 | proline rich 11 | -0.0175844 |
| HBP1 | HMG-box transcription factor 1 | -0.0175631 |
| CCDC91 | coiled-coil domain containing 91 | -0.0174851 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0173861 |
| KIF18B | kinesin family member 18B | -0.0170025 |
| DEK | DEK proto-oncogene | -0.0170023 |
| DNMBP | dynamin binding protein | -0.0169504 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0168932 |
| LAMA4 | laminin, alpha 4 | -0.0168748 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.016796 |
| HJURP | Holliday junction recognition protein | -0.0167924 |
| OSMR | oncostatin M receptor | -0.0167375 |
| TUBB | tubulin, beta class I | -0.0166766 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0164878 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0164734 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0163762 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.01627 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0162486 |
| NDC80 | NDC80 kinetochore complex component | -0.0162154 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0161125 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0160179 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0156441 |
| ANLN | anillin, actin binding protein | -0.0155049 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0153818 |
| KIF2C | kinesin family member 2C | -0.0153331 |
| CKAP2L | cytoskeleton associated protein 2-like | -0.0153119 |
| RIN2 | Ras and Rab interactor 2 | -0.0153049 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0152007 |
