| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | c-Kit-IN-1 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the c-Kit-IN-1_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.264094 |
| COL6A3 | collagen, type VI, alpha 3 | 0.207396 |
| FN1 | fibronectin 1 | 0.192157 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.15313 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.139461 |
| LDHA | lactate dehydrogenase A | 0.120987 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.117741 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.112969 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0878504 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0871132 |
| VCAN | versican | 0.073606 |
| HAS2 | hyaluronan synthase 2 | 0.0723292 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0721491 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0715948 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0673575 |
| FRMD5 | FERM domain containing 5 | 0.0644692 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.063135 |
| ATP13A3 | ATPase type 13A3 | 0.0629914 |
| PTK2 | protein tyrosine kinase 2 | 0.0628851 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0596747 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0575019 |
| PRELID2 | PRELI domain containing 2 | 0.057474 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0525812 |
| INHBA | inhibin, beta A | 0.0510073 |
| COG5 | component of oligomeric golgi complex 5 | 0.0487871 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0486929 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0462459 |
| TGFB2 | transforming growth factor, beta 2 | 0.045633 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0456043 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0432795 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0432608 |
| ENO1 | enolase 1, (alpha) | 0.0431972 |
| NDRG1 | N-myc downstream regulated 1 | 0.04226 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0422414 |
| NUP58 | nucleoporin 58 | 0.0419975 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0418122 |
| POSTN | periostin, osteoblast specific factor | 0.041104 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0408708 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0406814 |
| APP | amyloid beta (A4) precursor protein | 0.0403387 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0403287 |
| PDZRN3 | PDZ domain containing ring finger 3 | 0.039992 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0388807 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0388515 |
| MT1X | metallothionein 1X | 0.0375546 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0372147 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0360273 |
| MRTFA | myocardin related transcription factor A | 0.0354496 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.035439 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0352469 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0351791 |
| RUNX1 | runt-related transcription factor 1 | 0.0350995 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0345672 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0344906 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0344354 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.034406 |
| GOLGA4 | golgin A4 | 0.0340257 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0339259 |
| ARRDC3 | arrestin domain containing 3 | 0.0336016 |
| KPNB1 | karyopherin (importin) beta 1 | 0.032793 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0327387 |
| DST | dystonin | 0.0322262 |
| MAP1B | microtubule-associated protein 1B | 0.0311373 |
| GLIS3 | GLIS family zinc finger 3 | 0.030483 |
| RARB | retinoic acid receptor, beta | 0.0302293 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0301397 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0295349 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0295227 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0294219 |
| NAV2 | neuron navigator 2 | 0.0293185 |
| NBAS | neuroblastoma amplified sequence | 0.0286514 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0283561 |
| PLEC | plectin | 0.0283159 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0281704 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.027741 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0275335 |
| SPAG9 | sperm associated antigen 9 | 0.0273753 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0270098 |
| CADM1 | cell adhesion molecule 1 | 0.0268442 |
| FAT1 | FAT atypical cadherin 1 | 0.0267361 |
| GPC6 | glypican 6 | 0.026233 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0261155 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0260071 |
| STC1 | stanniocalcin 1 | 0.0259357 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0255714 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0255448 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.025446 |
| CLTC | clathrin, heavy chain (Hc) | 0.0253749 |
| ZNF292 | zinc finger protein 292 | 0.0249832 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0248861 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0247615 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.024722 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0246589 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0245765 |
| TFG | TRK-fused gene | 0.024571 |
| CLINT1 | clathrin interactor 1 | 0.0245374 |
| MT2A | metallothionein 2A | 0.0245367 |
| TFRC | transferrin receptor | 0.0240033 |
| FOXP1 | forkhead box P1 | 0.0239956 |
| YEATS2 | YEATS domain containing 2 | 0.0238641 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.109927 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0987028 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0909863 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0639015 |
| COL1A1 | collagen, type I, alpha 1 | -0.0529451 |
| COL1A2 | collagen, type I, alpha 2 | -0.0519495 |
| RPS8 | ribosomal protein S8 | -0.0516497 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0515763 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0492635 |
| RPS6 | ribosomal protein S6 | -0.0462651 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0435541 |
| HLA-B | major histocompatibility complex, class I, B | -0.0412423 |
| RPL11 | ribosomal protein L11 | -0.0396978 |
| VCL | vinculin | -0.0372305 |
| SQSTM1 | sequestosome 1 | -0.0369527 |
| RPS3 | ribosomal protein S3 | -0.0339418 |
| LOX | lysyl oxidase | -0.0330663 |
| EGFR | epidermal growth factor receptor | -0.0328691 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0322138 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.031341 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0300989 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0299921 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0297302 |
| GOLGB1 | golgin B1 | -0.02961 |
| RPL37A | ribosomal protein L37a | -0.0286592 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0278998 |
| FBN1 | fibrillin 1 | -0.0277247 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0271171 |
| EGR1 | early growth response 1 | -0.0263762 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0262378 |
| RPS27A | ribosomal protein S27a | -0.0261044 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0257749 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0255224 |
| ACTG1 | actin gamma 1 | -0.0254068 |
| RPL8 | ribosomal protein L8 | -0.0252007 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0229182 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0226698 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0226317 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0221204 |
| RPS12 | ribosomal protein S12 | -0.0218666 |
| B2M | beta-2-microglobulin | -0.0214046 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0213878 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.021369 |
| INTS6 | integrator complex subunit 6 | -0.0208124 |
| TPM1 | tropomyosin 1 (alpha) | -0.0207394 |
| RPL28 | ribosomal protein L28 | -0.02073 |
| RPL31 | ribosomal protein L31 | -0.0207265 |
| RPS29 | ribosomal protein S29 | -0.0204297 |
| CDH13 | cadherin 13 | -0.0203089 |
| RPS13 | ribosomal protein S13 | -0.0203028 |
| CAVIN1 | caveolae associated protein 1 | -0.0202972 |
| FBXO32 | F-box protein 32 | -0.0200995 |
| CUX1 | cut-like homeobox 1 | -0.0200755 |
| RPL12 | ribosomal protein L12 | -0.019522 |
| RPL13A | ribosomal protein L13a | -0.0191622 |
| RPL19 | ribosomal protein L19 | -0.0190181 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0186932 |
| RPS17 | ribosomal protein S17 | -0.0185625 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0185432 |
| COL6A2 | collagen, type VI, alpha 2 | -0.018523 |
| PRR16 | proline rich 16 | -0.0183256 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0179879 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0177797 |
| NEK10 | NIMA-related kinase 10 | -0.0177237 |
| RPLP2 | ribosomal protein, large, P2 | -0.017693 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0175481 |
| RPS2 | ribosomal protein S2 | -0.0175301 |
| YBX1 | Y box binding protein 1 | -0.0173761 |
| RPS15 | ribosomal protein S15 | -0.0172971 |
| HBP1 | HMG-box transcription factor 1 | -0.0171967 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0169587 |
| TMSB10 | thymosin beta 10 | -0.0169324 |
| SP100 | SP100 nuclear antigen | -0.0169096 |
| TPM4 | tropomyosin 4 | -0.0168884 |
| FTL | ferritin, light polypeptide | -0.0168213 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0167811 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.016431 |
| RPS20 | ribosomal protein S20 | -0.0163149 |
| CCDC91 | coiled-coil domain containing 91 | -0.0162915 |
| RPS14 | ribosomal protein S14 | -0.0162409 |
| HLA-A | major histocompatibility complex, class I, A | -0.0160516 |
| ATM | ATM serine/threonine kinase | -0.0160394 |
| RPL9 | ribosomal protein L9 | -0.0159556 |
| PHF3 | PHD finger protein 3 | -0.0158483 |
| RBPMS | RNA binding protein with multiple splicing | -0.0158348 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0156098 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0155142 |
| KAT6B | K(lysine) acetyltransferase 6B | -0.0154613 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0154513 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0153718 |
| MTDH | metadherin | -0.0153458 |
| KLHL24 | kelch-like family member 24 | -0.0152638 |
| CDC37 | cell division cycle 37 | -0.0149511 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.014534 |
| AHNAK | AHNAK nucleoprotein | -0.0144797 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0144599 |
| MYADM | myeloid-associated differentiation marker | -0.0144053 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0144045 |
| KLF12 | Kruppel-like factor 12 | -0.0143446 |
| WASF2 | WAS protein family, member 2 | -0.0143353 |
