c-Kit-IN-1_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.186764
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.181878
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.156971
SAMD4A sterile alpha motif domain containing 4A 0.13868
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.125004
LRMDA leucine rich melanocyte differentiation associated 0.108558
DTNA dystrobrevin, alpha 0.102718
TRIO trio Rho guanine nucleotide exchange factor 0.0980054
ASPH aspartate beta-hydroxylase 0.0789279
KIF1B kinesin family member 1B 0.0754319
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0704306
GPC6 glypican 6 0.0678047
KIAA1217 KIAA1217 0.0675799
MSI2 musashi RNA-binding protein 2 0.0669621
DST dystonin 0.0653578
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0645093
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0627214
FRMD5 FERM domain containing 5 0.0618881
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0575148
APOB apolipoprotein B 0.0567914
SOD2 superoxide dismutase 2, mitochondrial 0.0550738
ZFAND3 zinc finger, AN1-type domain 3 0.0526795
RUNX1 runt-related transcription factor 1 0.0523946
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0515541
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0501362
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.050072
SVIL supervillin 0.0492239
TXNRD1 thioredoxin reductase 1 0.0487383
CD109 CD109 molecule 0.0485499
AKAP12 A kinase (PRKA) anchor protein 12 0.0482713
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0471675
PTPRM protein tyrosine phosphatase, receptor type, M 0.0469378
FMNL2 formin-like 2 0.0443807
ENO1 enolase 1, (alpha) 0.0442437
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0442168
MYH9 myosin, heavy chain 9, non-muscle 0.0440037
CFB complement factor B 0.042412
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0422528
SOX5 SRY (sex determining region Y)-box 5 0.0421156
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0420303
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0414505
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0412673
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0407909
LDHA lactate dehydrogenase A 0.0402994
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0398918
MYO1B myosin IB 0.0392076
OSBPL3 oxysterol binding protein-like 3 0.0389189
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0388132
MACF1 microtubule-actin crosslinking factor 1 0.0387714
WDR43 WD repeat domain 43 0.0379947
FNIP1 folliculin interacting protein 1 0.0378587
FLNB filamin B, beta 0.0373942
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0370877
RTN4 reticulon 4 0.0365479
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0365432
FHIT fragile histidine triad 0.0363382
AFDN afadin, adherens junction formation factor 0.0360682
USP34 ubiquitin specific peptidase 34 0.036026
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0355116
SPAG9 sperm associated antigen 9 0.0345496
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0344308
EXT1 exostosin glycosyltransferase 1 0.0343778
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0339405
RBM39 RNA binding motif protein 39 0.0338214
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0333922
ANO6 anoctamin 6 0.0331759
NGLY1 N-glycanase 1 0.0330671
FN1 fibronectin 1 0.0327327
GRB10 growth factor receptor-bound protein 10 0.0321788
ANKRD10 ankyrin repeat domain 10 0.0321491
PTK2 protein tyrosine kinase 2 0.0321043
ATXN1 ataxin 1 0.0317852
RABGAP1L RAB GTPase activating protein 1-like 0.0316957
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0313052
DSPP dentin sialophosphoprotein 0.0311796
FAM135A family with sequence similarity 135, member A 0.0309557
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0308858
CCNY cyclin Y 0.030645
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0304439
KYNU kynureninase 0.0299926
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0298436
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0295951
FAM107B family with sequence similarity 107, member B 0.0295211
KMT2C lysine (K)-specific methyltransferase 2C 0.0293833
OSMR oncostatin M receptor 0.0293702
TFRC transferrin receptor 0.0291731
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0291245
SEPTIN10 septin 10 0.0291053
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0288754
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.0288209
ZEB1 zinc finger E-box binding homeobox 1 0.0287465
ARFGEF3 ARFGEF family member 3 0.0287195
ARHGAP5 Rho GTPase activating protein 5 0.0285209
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0284742
PCBP2 poly(rC) binding protein 2 0.0284076
GMDS GDP-mannose 4,6-dehydratase 0.028331
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0281244
SRPK1 SRSF protein kinase 1 0.0279402
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0279046
NUP58 nucleoporin 58 0.0276265

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.404051
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.170282
MT2A metallothionein 2A -0.136606
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120143
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.11806
TPT1 tumor protein, translationally-controlled 1 -0.0930443
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0925973
SLC38A2 solute carrier family 38, member 2 -0.0848235
C3 complement component 3 -0.0810573
APOA2 apolipoprotein A-II -0.0768117
RPS6 ribosomal protein S6 -0.0754099
IGFBP1 insulin-like growth factor binding protein 1 -0.0645733
FTL ferritin, light polypeptide -0.0570427
RPLP1 ribosomal protein, large, P1 -0.0508874
RPS8 ribosomal protein S8 -0.048398
MAML2 mastermind-like 2 (Drosophila) -0.0468518
GPC3 glypican 3 -0.044232
RPS19 ribosomal protein S19 -0.044099
RPL11 ribosomal protein L11 -0.0439295
TM4SF1 transmembrane 4 L six family member 1 -0.0411397
NKD1 naked cuticle homolog 1 (Drosophila) -0.040653
AHSG alpha-2-HS-glycoprotein -0.037901
APOA1 apolipoprotein A-I -0.0359986
TNRC6B trinucleotide repeat containing 6B -0.0354637
RPL31 ribosomal protein L31 -0.0354342
TMSB10 thymosin beta 10 -0.0354252
RPLP0 ribosomal protein, large, P0 -0.0350565
FBF1 Fas (TNFRSF6) binding factor 1 -0.0346229
RPS27A ribosomal protein S27a -0.0343512
STAU1 staufen double-stranded RNA binding protein 1 -0.0331402
TRIM26 tripartite motif containing 26 -0.0322589
RPL35A ribosomal protein L35a -0.0320301
RPLP2 ribosomal protein, large, P2 -0.0309648
RPL37A ribosomal protein L37a -0.0309218
RPS24 ribosomal protein S24 -0.030694
RPL12 ribosomal protein L12 -0.0304165
APOE apolipoprotein E -0.0302879
RACK1 receptor for activated C kinase 1 -0.0300398
RPS29 ribosomal protein S29 -0.0295724
RPL34 ribosomal protein L34 -0.0295247
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0289795
RPL19 ribosomal protein L19 -0.0284935
AMBP alpha-1-microglobulin/bikunin precursor -0.028402
RPS23 ribosomal protein S23 -0.028149
DLC1 DLC1 Rho GTPase activating protein -0.0280409
PTCHD4 patched domain containing 4 -0.0277778
RPS12 ribosomal protein S12 -0.027617
GCC2 GRIP and coiled-coil domain containing 2 -0.0274615
RPS3 ribosomal protein S3 -0.027126
RPS14 ribosomal protein S14 -0.0258124
RPS5 ribosomal protein S5 -0.0256643
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 -0.0255337
FTH1 ferritin, heavy polypeptide 1 -0.0254587
CPE carboxypeptidase E -0.0252045
FOXP1 forkhead box P1 -0.0250669
EGR1 early growth response 1 -0.0247011
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0242402
ITGA1 integrin, alpha 1 -0.0242256
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0234497
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0229829
KRT18 keratin 18, type I -0.0228863
RPS21 ribosomal protein S21 -0.0227712
GNAS GNAS complex locus -0.0226272
RB1CC1 RB1-inducible coiled-coil 1 -0.0218376
LMCD1 LIM and cysteine-rich domains 1 -0.0217469
A2M alpha-2-macroglobulin -0.0217414
RPS25 ribosomal protein S25 -0.0217352
RPS13 ribosomal protein S13 -0.0216989
AKAP9 A kinase (PRKA) anchor protein 9 -0.0214736
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0214043
PHF3 PHD finger protein 3 -0.0212324
EIF1 eukaryotic translation initiation factor 1 -0.0208363
B2M beta-2-microglobulin -0.0206631
RPL8 ribosomal protein L8 -0.0204542
VCL vinculin -0.0203881
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0195593
ZMYND8 zinc finger, MYND-type containing 8 -0.0195075
RPL5 ribosomal protein L5 -0.019422
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.019396
RPL26 ribosomal protein L26 -0.0192628
CCND1 cyclin D1 -0.019243
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0188055
RPL28 ribosomal protein L28 -0.0187634
CST3 cystatin C -0.0183648
IER3 immediate early response 3 -0.0183601
RPS17 ribosomal protein S17 -0.0183263
PERP PERP, TP53 apoptosis effector -0.0182318
PTMA prothymosin, alpha -0.0181663
GDF15 growth differentiation factor 15 -0.0180094
RPL37 ribosomal protein L37 -0.0179908
EPAS1 endothelial PAS domain protein 1 -0.0179821
EML4 echinoderm microtubule associated protein like 4 -0.0179778
SORL1 sortilin-related receptor, L(DLR class) A repeats containing -0.0178468
RPL13A ribosomal protein L13a -0.017687
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0174605
RPS10 ribosomal protein S10 -0.0174108
KLF6 Kruppel-like factor 6 -0.0172947
RRBP1 ribosome binding protein 1 -0.0171378
LYZ lysozyme -0.0167129
VIM vimentin -0.0162297