c-Kit-IN-1_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PALM2AKAP2 PALM2 and AKAP2 fusion 0.129994
GRB10 growth factor receptor-bound protein 10 0.109498
MACF1 microtubule-actin crosslinking factor 1 0.0987532
SLC35F3 solute carrier family 35, member F3 0.0936373
PTK2 protein tyrosine kinase 2 0.0873102
PLEC plectin 0.0826835
ATP13A3 ATPase type 13A3 0.0751348
PODXL podocalyxin-like 0.0656384
F3 coagulation factor III (thromboplastin, tissue factor) 0.0624449
NUP58 nucleoporin 58 0.0619356
MTSS1 metastasis suppressor 1 0.0611209
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0610981
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0583511
SPAG9 sperm associated antigen 9 0.0558524
RAI14 retinoic acid induced 14 0.0546225
DST dystonin 0.0539614
KMT2C lysine (K)-specific methyltransferase 2C 0.0526644
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0520243
MYH9 myosin, heavy chain 9, non-muscle 0.0511722
SIK3 SIK family kinase 3 0.0501749
RLF rearranged L-myc fusion 0.0490494
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0484616
QKI QKI, KH domain containing, RNA binding 0.0483649
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0474065
BCAR3 breast cancer anti-estrogen resistance 3 0.0470374
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0466904
PITPNB phosphatidylinositol transfer protein, beta 0.0461161
TOP1 topoisomerase (DNA) I 0.0461089
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0458947
FRMD5 FERM domain containing 5 0.0456439
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0451556
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0444837
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.044024
PICALM phosphatidylinositol binding clathrin assembly protein 0.0437004
PRRC2C proline-rich coiled-coil 2C 0.0433526
NAMPT nicotinamide phosphoribosyltransferase 0.043219
ZFAND3 zinc finger, AN1-type domain 3 0.0429693
TRIO trio Rho guanine nucleotide exchange factor 0.0428758
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0427482
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0422959
NRCAM neuronal cell adhesion molecule 0.041905
FNDC3B fibronectin type III domain containing 3B 0.0417957
ANKRD11 ankyrin repeat domain 11 0.0414815
BHLHE40 basic helix-loop-helix family, member e40 0.0411179
AMOTL1 angiomotin like 1 0.0410584
ZEB1 zinc finger E-box binding homeobox 1 0.0401687
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0401357
IPO7 importin 7 0.0392186
HSPA8 heat shock 70kDa protein 8 0.0388618
PDZD8 PDZ domain containing 8 0.0387773
ACTG1 actin gamma 1 0.0379655
STK4 serine/threonine kinase 4 0.0378238
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0375962
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0375119
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0374649
ANKRD28 ankyrin repeat domain 28 0.0369947
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0368608
DOCK4 dedicator of cytokinesis 4 0.0367375
HSPH1 heat shock 105kDa/110kDa protein 1 0.0364789
ECPAS Ecm29 proteasome adaptor and scaffold 0.0363439
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0361778
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0359118
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0356808
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.03549
MKI67 marker of proliferation Ki-67 0.0352583
NAV2 neuron navigator 2 0.0350082
EXT1 exostosin glycosyltransferase 1 0.0347828
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0346584
ARHGAP29 Rho GTPase activating protein 29 0.0340777
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.033902
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0335147
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0334996
PDE4D phosphodiesterase 4D, cAMP-specific 0.0333914
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0330718
MYO10 myosin X 0.0326363
RAB7A RAB7A, member RAS oncogene family 0.0325771
EIF3A eukaryotic translation initiation factor 3, subunit A 0.032512
GSK3B glycogen synthase kinase 3 beta 0.0322733
PEAK1 pseudopodium-enriched atypical kinase 1 0.0320265
AFF4 AF4/FMR2 family, member 4 0.0318743
TXNRD1 thioredoxin reductase 1 0.0317146
CORO1C coronin, actin binding protein, 1C 0.0315791
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0315718
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0314681
CHD1 chromodomain helicase DNA binding protein 1 0.0310251
LHFPL6 LHFPL tetraspan subfamily member 6 0.0306577
BIRC3 baculoviral IAP repeat containing 3 0.0305655
NAP1L1 nucleosome assembly protein 1-like 1 0.0304203
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0303169
TPM3 tropomyosin 3 0.0302745
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0301988
PSD3 pleckstrin and Sec7 domain containing 3 0.0300848
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0300717
RIGI RNA sensor RIG-I 0.0300293
FAR1 fatty acyl CoA reductase 1 0.0299133
NRIP1 nuclear receptor interacting protein 1 0.0298652
RABGAP1L RAB GTPase activating protein 1-like 0.0294068
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0292837
LAMC2 laminin, gamma 2 0.0291412
GPHN gephyrin 0.0290969

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.153192
FLNB filamin B, beta -0.0997819
TMSB10 thymosin beta 10 -0.0858403
NDRG1 N-myc downstream regulated 1 -0.085691
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0787243
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0766516
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0675664
CLU clusterin -0.0644281
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0641364
PTMA prothymosin, alpha -0.0576197
AKAP9 A kinase (PRKA) anchor protein 9 -0.0555834
EMP1 epithelial membrane protein 1 -0.0534325
B2M beta-2-microglobulin -0.0523474
UBC ubiquitin C -0.0508459
CEMIP cell migration inducing protein, hyaluronan binding -0.0475116
WASF2 WAS protein family, member 2 -0.046783
CAV1 caveolin 1, caveolae protein, 22kDa -0.0464838
OGA O-GlcNAcase -0.0458136
RPS6 ribosomal protein S6 -0.0450445
SERINC3 serine incorporator 3 -0.0446566
S100A10 S100 calcium binding protein A10 -0.04463
FN1 fibronectin 1 -0.0442022
FOXO1 forkhead box O1 -0.0440624
ANXA2 annexin A2 -0.0440622
CUL4B cullin 4B -0.0403707
COPB1 coatomer protein complex, subunit beta 1 -0.0403302
YBX3 Y box binding protein 3 -0.0396951
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0393682
HM13 histocompatibility (minor) 13 -0.0393049
RPLP2 ribosomal protein, large, P2 -0.0386839
SULF1 sulfatase 1 -0.0382621
NEK7 NIMA-related kinase 7 -0.0367687
TMSB4X thymosin beta 4, X-linked -0.0364751
MT2A metallothionein 2A -0.0363031
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0358888
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0358342
RIN2 Ras and Rab interactor 2 -0.0352763
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0338838
CD99 CD99 molecule -0.0337039
MBNL2 muscleblind-like splicing regulator 2 -0.033647
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0336054
SLC38A2 solute carrier family 38, member 2 -0.033251
TNRC6B trinucleotide repeat containing 6B -0.0331738
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0329218
RB1CC1 RB1-inducible coiled-coil 1 -0.0326872
IFITM3 interferon induced transmembrane protein 3 -0.0319667
IGF2 insulin-like growth factor 2 -0.0315821
SBF2 SET binding factor 2 -0.0312861
RPS8 ribosomal protein S8 -0.0310545
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0309974
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0309835
ANXA1 annexin A1 -0.0303826
LMAN1 lectin, mannose-binding, 1 -0.0295634
DPYD dihydropyrimidine dehydrogenase -0.0293462
COL17A1 collagen, type XVII, alpha 1 -0.0290348
ZMYND8 zinc finger, MYND-type containing 8 -0.0290197
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0288305
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0282128
HDLBP high density lipoprotein binding protein -0.0282054
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281801
PLAT plasminogen activator, tissue -0.0276852
CANX calnexin -0.0276803
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0273657
FSCN1 fascin actin-bundling protein 1 -0.0273147
ARF4 ADP-ribosylation factor 4 -0.0271318
COG6 component of oligomeric golgi complex 6 -0.0270566
KRT17 keratin 17, type I -0.0270057
RPL37A ribosomal protein L37a -0.0269717
MYOF myoferlin -0.0266374
ENO1 enolase 1, (alpha) -0.0265965
IFITM1 interferon induced transmembrane protein 1 -0.026189
GOLGA2 golgin A2 -0.0261093
LIMA1 LIM domain and actin binding 1 -0.0260869
TAGLN2 transgelin 2 -0.0260303
BCL2L1 BCL2-like 1 -0.0255225
RPS3 ribosomal protein S3 -0.0254008
HLA-B major histocompatibility complex, class I, B -0.0253408
S100A6 S100 calcium binding protein A6 -0.025327
KDM5B lysine (K)-specific demethylase 5B -0.0253043
NUCB2 nucleobindin 2 -0.0249152
IL1RAP interleukin 1 receptor accessory protein -0.0248846
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0248552
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0247755
PKM pyruvate kinase, muscle -0.0243985
GLG1 golgi glycoprotein 1 -0.0243926
PIBF1 progesterone immunomodulatory binding factor 1 -0.0243866
GOLPH3L golgi phosphoprotein 3-like -0.0243633
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0241114
RACK1 receptor for activated C kinase 1 -0.02411
RPS27A ribosomal protein S27a -0.0240595
SEC31A SEC31 homolog A (S. cerevisiae) -0.0239382
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0239135
METTL15 methyltransferase like 15 -0.0237479
OSMR oncostatin M receptor -0.0234945
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0234587
PDIA3 protein disulfide isomerase family A, member 3 -0.0233318
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.023253
RSF1 remodeling and spacing factor 1 -0.0232251
ITGA6 integrin, alpha 6 -0.0230015
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0228935