c-Kit-IN-1_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.123452
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.117706
TRIO trio Rho guanine nucleotide exchange factor 0.115773
MYH9 myosin, heavy chain 9, non-muscle 0.0821931
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0726807
PHACTR1 phosphatase and actin regulator 1 0.0703009
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0683964
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0666953
ATP13A3 ATPase type 13A3 0.0610997
NAV2 neuron navigator 2 0.0590814
FLNA filamin A, alpha 0.0522454
FLNB filamin B, beta 0.0519985
ASPH aspartate beta-hydroxylase 0.0503854
FNIP1 folliculin interacting protein 1 0.0480116
PTK2 protein tyrosine kinase 2 0.047995
SOD2 superoxide dismutase 2, mitochondrial 0.0478545
AHNAK AHNAK nucleoprotein 0.0477786
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0477605
DST dystonin 0.0462125
PLEC plectin 0.0435649
SMYD3 SET and MYND domain containing 3 0.042646
LPP LIM domain containing preferred translocation partner in lipoma 0.0421726
SLIT2 slit homolog 2 (Drosophila) 0.0420771
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0416733
PTPRG protein tyrosine phosphatase, receptor type, G 0.0398585
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0395598
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0395563
UBA6 ubiquitin-like modifier activating enzyme 6 0.0388711
EEF2 eukaryotic translation elongation factor 2 0.0386686
ZFAND3 zinc finger, AN1-type domain 3 0.0384111
TENM3 teneurin transmembrane protein 3 0.0375532
DTNA dystrobrevin, alpha 0.0368886
PRELID2 PRELI domain containing 2 0.0368819
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.036491
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0344894
HSPH1 heat shock 105kDa/110kDa protein 1 0.0343322
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0338491
COL5A1 collagen, type V, alpha 1 0.033763
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0336051
NUP58 nucleoporin 58 0.033273
GMDS GDP-mannose 4,6-dehydratase 0.0326881
ANKRD11 ankyrin repeat domain 11 0.0326227
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0322849
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0322322
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0321032
PTPRM protein tyrosine phosphatase, receptor type, M 0.031947
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0314543
JARID2 jumonji, AT rich interactive domain 2 0.0313973
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0313658
PRRC2A proline-rich coiled-coil 2A 0.0310308
RUNX1 runt-related transcription factor 1 0.0309672
USP9X ubiquitin specific peptidase 9, X-linked 0.0309563
FTH1 ferritin, heavy polypeptide 1 0.0307779
FAR1 fatty acyl CoA reductase 1 0.0307012
INTS6 integrator complex subunit 6 0.0304078
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0303699
LRMDA leucine rich melanocyte differentiation associated 0.0301358
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0299599
ANKRD10 ankyrin repeat domain 10 0.0298934
FAF1 Fas (TNFRSF6) associated factor 1 0.0293724
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0290987
LHFPL2 lipoma HMGIC fusion partner-like 2 0.029065
FHIT fragile histidine triad 0.0289636
PRRC2B proline-rich coiled-coil 2B 0.028953
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0288713
TLE4 transducin-like enhancer of split 4 0.0286614
GLIS3 GLIS family zinc finger 3 0.0281847
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0273939
BHLHE40 basic helix-loop-helix family, member e40 0.0273323
GPHN gephyrin 0.0269784
APP amyloid beta (A4) precursor protein 0.0269334
HSPA8 heat shock 70kDa protein 8 0.0269221
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0268961
SPTBN1 spectrin, beta, non-erythrocytic 1 0.026783
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0267315
LGALS12 lectin, galactoside-binding, soluble, 12 0.0265452
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.02654
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0259464
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0258612
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.025801
AFF4 AF4/FMR2 family, member 4 0.0255444
TFRC transferrin receptor 0.0255261
GLS2 glutaminase 2 (liver, mitochondrial) 0.0254988
ZSWIM6 zinc finger, SWIM-type containing 6 0.0254962
CORO1C coronin, actin binding protein, 1C 0.0254123
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0253822
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0253801
OLA1 Obg-like ATPase 1 0.0252165
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0252156
CTNNBL1 catenin, beta like 1 0.0251761
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0249987
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0249397
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 0.0246179
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0245152
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.024505
PIAS2 protein inhibitor of activated STAT, 2 0.0243385
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0241378
PICALM phosphatidylinositol binding clathrin assembly protein 0.0241131
SND1 staphylococcal nuclease and tudor domain containing 1 0.0241095
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0239354

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.237999
MT2A metallothionein 2A -0.234833
FTL ferritin, light polypeptide -0.222573
HLA-B major histocompatibility complex, class I, B -0.171328
UGCG UDP-glucose ceramide glucosyltransferase -0.114896
B2M beta-2-microglobulin -0.108649
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.102937
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0974115
PTMA prothymosin, alpha -0.0689532
NDRG1 N-myc downstream regulated 1 -0.0670472
DEK DEK proto-oncogene -0.0667887
RPS6 ribosomal protein S6 -0.0666022
TMSB10 thymosin beta 10 -0.0633932
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0615591
MT1X metallothionein 1X -0.0598984
POTEF POTE ankyrin domain family, member F -0.0588285
RPLP2 ribosomal protein, large, P2 -0.0579663
MARCKS myristoylated alanine-rich protein kinase C substrate -0.055622
CD44 CD44 molecule (Indian blood group) -0.0547264
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0535733
BASP1 brain abundant, membrane attached signal protein 1 -0.0484235
VIM vimentin -0.0470123
CENPF centromere protein F, 350/400kDa -0.045326
IGFBP3 insulin-like growth factor binding protein 3 -0.0426486
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0422814
PFN1 profilin 1 -0.0407356
HEG1 heart development protein with EGF-like domains 1 -0.0406066
TPX2 TPX2, microtubule-associated -0.0393678
ACTG1 actin gamma 1 -0.0376525
PTBP3 polypyrimidine tract binding protein 3 -0.0371569
ADM adrenomedullin -0.036738
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0359591
FN1 fibronectin 1 -0.0336416
NEK7 NIMA-related kinase 7 -0.0335954
RPLP1 ribosomal protein, large, P1 -0.0333715
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0332105
GNAS GNAS complex locus -0.0328237
CTSD cathepsin D -0.0327692
S100A10 S100 calcium binding protein A10 -0.0327381
TPI1 triosephosphate isomerase 1 -0.0325289
RPL12 ribosomal protein L12 -0.032392
RPL35A ribosomal protein L35a -0.0321219
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0318966
S100A6 S100 calcium binding protein A6 -0.0315633
ENO1 enolase 1, (alpha) -0.0312623
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0300995
RPL28 ribosomal protein L28 -0.0299641
IFI6 interferon, alpha-inducible protein 6 -0.0297818
TPT1 tumor protein, translationally-controlled 1 -0.0297344
TMSB4X thymosin beta 4, X-linked -0.0295929
ELL2 elongation factor, RNA polymerase II, 2 -0.0290728
POSTN periostin, osteoblast specific factor -0.0290617
HLA-A major histocompatibility complex, class I, A -0.0289736
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0288588
RPS13 ribosomal protein S13 -0.0287808
TPM1 tropomyosin 1 (alpha) -0.0281145
RHOBTB3 Rho-related BTB domain containing 3 -0.0278822
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0275591
RPS21 ribosomal protein S21 -0.0274662
GRAMD2B GRAM domain containing 2B -0.0274557
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0274309
MKI67 marker of proliferation Ki-67 -0.0273476
ABI3BP ABI family, member 3 (NESH) binding protein -0.0272332
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0266482
MYL12B myosin, light chain 12B, regulatory -0.0266348
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0262826
UBC ubiquitin C -0.0259017
SULF1 sulfatase 1 -0.0257712
COPB1 coatomer protein complex, subunit beta 1 -0.0251743
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0247839
AKAP12 A kinase (PRKA) anchor protein 12 -0.0247159
ARF4 ADP-ribosylation factor 4 -0.0246564
ERBIN erbb2 interacting protein -0.0246086
LATS2 large tumor suppressor kinase 2 -0.0245168
SEPTIN7 septin 7 -0.0244855
LDHA lactate dehydrogenase A -0.0243825
RPS2 ribosomal protein S2 -0.0243222
PSIP1 PC4 and SFRS1 interacting protein 1 -0.0242001
RPL37 ribosomal protein L37 -0.0241957
CUL4B cullin 4B -0.0240329
RPL37A ribosomal protein L37a -0.024004
RPS8 ribosomal protein S8 -0.0238254
RPL27A ribosomal protein L27a -0.0238066
HMGB2 high mobility group box 2 -0.0237807
GOLT1B golgi transport 1B -0.0237423
RPS3 ribosomal protein S3 -0.0237131
IFITM3 interferon induced transmembrane protein 3 -0.023708
RAD21 RAD21 homolog (S. pombe) -0.0235119
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0233739
PKM pyruvate kinase, muscle -0.0232403
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0231475
RIOK3 RIO kinase 3 -0.0228745
RB1CC1 RB1-inducible coiled-coil 1 -0.0224045
S100A9 S100 calcium binding protein A9 -0.0222353
RRBP1 ribosome binding protein 1 -0.0220911
H1-4 H1.4 linker histone, cluster member -0.0219494
ANKRD12 ankyrin repeat domain 12 -0.0219024
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0218889
CD99 CD99 molecule -0.0218602
TUBA1B tubulin, alpha 1b -0.0218261