c-Kit-IN-1_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.097155
GMDS GDP-mannose 4,6-dehydratase 0.0953723
FNDC3B fibronectin type III domain containing 3B 0.0907976
FRMD5 FERM domain containing 5 0.0833767
CMIP c-Maf inducing protein 0.0705878
EXT1 exostosin glycosyltransferase 1 0.0654054
GOLGA4 golgin A4 0.0635775
IL1RAP interleukin 1 receptor accessory protein 0.0617118
MYH9 myosin, heavy chain 9, non-muscle 0.0554665
MACC1 metastasis associated in colon cancer 1 0.055134
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0545027
ZFAND3 zinc finger, AN1-type domain 3 0.0533947
FNIP1 folliculin interacting protein 1 0.0526101
IARS1 isoleucyl-tRNA synthetase 1 0.0520198
SND1 staphylococcal nuclease and tudor domain containing 1 0.0481809
KLHL29 kelch-like family member 29 0.047992
HSPA8 heat shock 70kDa protein 8 0.0473638
GARS1 glycyl-tRNA synthetase 1 0.0450407
SPAG9 sperm associated antigen 9 0.0424371
PLEC plectin 0.0418833
TRIO trio Rho guanine nucleotide exchange factor 0.0415655
EIF4A2 eukaryotic translation initiation factor 4A2 0.0412314
DST dystonin 0.0397512
MBNL1 muscleblind-like splicing regulator 1 0.0395946
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0395313
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0394899
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0394703
GRB10 growth factor receptor-bound protein 10 0.0392161
PMM2 phosphomannomutase 2 0.0385252
CLTC clathrin, heavy chain (Hc) 0.0381961
COG5 component of oligomeric golgi complex 5 0.0379493
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0376234
VEGFA vascular endothelial growth factor A 0.0369024
TSC22D2 TSC22 domain family, member 2 0.0365439
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.035989
EEF2 eukaryotic translation elongation factor 2 0.0358565
NUP58 nucleoporin 58 0.035748
PRELID2 PRELI domain containing 2 0.0354247
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0351665
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.035031
RAB6A RAB6A, member RAS oncogene family 0.0339621
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0338939
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0338633
ZNF292 zinc finger protein 292 0.0337344
NBAS neuroblastoma amplified sequence 0.0331237
AKAP13 A kinase (PRKA) anchor protein 13 0.0330832
LPP LIM domain containing preferred translocation partner in lipoma 0.0329216
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0323504
PCBP2 poly(rC) binding protein 2 0.0321744
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0315367
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0311878
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0308721
ARCN1 archain 1 0.0304137
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0303972
PTK2 protein tyrosine kinase 2 0.0303751
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0300217
ANO6 anoctamin 6 0.0297403
RAB7A RAB7A, member RAS oncogene family 0.0296499
HKDC1 hexokinase domain containing 1 0.0295654
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.029509
COPG1 coatomer protein complex, subunit gamma 1 0.0294489
AHR aryl hydrocarbon receptor 0.0292723
CCNY cyclin Y 0.0287848
AVL9 AVL9 homolog (S. cerevisiase) 0.0285838
CREB5 cAMP responsive element binding protein 5 0.0285068
SRRM2 serine/arginine repetitive matrix 2 0.0284234
NF1 neurofibromin 1 0.0283573
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0282208
WDR43 WD repeat domain 43 0.0281003
ANKRD10 ankyrin repeat domain 10 0.0277161
RUNX1 runt-related transcription factor 1 0.0276499
RASEF RAS and EF-hand domain containing 0.0276464
YEATS2 YEATS domain containing 2 0.0275701
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0274385
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0274101
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0273471
BACE2 beta-site APP-cleaving enzyme 2 0.0267229
USP34 ubiquitin specific peptidase 34 0.0259456
KMT2C lysine (K)-specific methyltransferase 2C 0.0258547
TFRC transferrin receptor 0.0256323
RNGTT RNA guanylyltransferase and 5'-phosphatase 0.0255928
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254934
ITCH itchy E3 ubiquitin protein ligase 0.0254823
COPA coatomer protein complex, subunit alpha 0.0254216
RTN4 reticulon 4 0.0253935
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0252803
SIK3 SIK family kinase 3 0.0248508
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.0246488
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0246422
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0245878
FAM219A family with sequence similarity 219, member A 0.0245141
PTPRG protein tyrosine phosphatase, receptor type, G 0.0244631
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0244224
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0243909
SLTM SAFB-like, transcription modulator 0.0242531
CXCL8 chemokine (C-X-C motif) ligand 8 0.0239213
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0236222
KIF16B kinesin family member 16B 0.0232426
SAMD12 sterile alpha motif domain containing 12 0.0231275
CANX calnexin 0.0230024

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.223596
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.167258
NPSR1 neuropeptide S receptor 1 -0.147496
PTMA prothymosin, alpha -0.135032
TPT1 tumor protein, translationally-controlled 1 -0.11786
FTL ferritin, light polypeptide -0.108973
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106045
S100A6 S100 calcium binding protein A6 -0.0909753
B2M beta-2-microglobulin -0.0872869
AGR2 anterior gradient 2 -0.0870779
RPL35A ribosomal protein L35a -0.0831044
S100A10 S100 calcium binding protein A10 -0.0805817
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0799968
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0796666
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0753048
RPLP1 ribosomal protein, large, P1 -0.071688
RPS6 ribosomal protein S6 -0.0697931
RPS19 ribosomal protein S19 -0.0662805
MAML2 mastermind-like 2 (Drosophila) -0.0648527
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0644401
S100P S100 calcium binding protein P -0.0629789
IFI27 interferon, alpha-inducible protein 27 -0.0612832
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0605841
EIF1 eukaryotic translation initiation factor 1 -0.057227
KRT18 keratin 18, type I -0.0567053
RPL23 ribosomal protein L23 -0.0556619
S100A9 S100 calcium binding protein A9 -0.0548998
RPS8 ribosomal protein S8 -0.0543029
RPS21 ribosomal protein S21 -0.0519291
RPS25 ribosomal protein S25 -0.0489091
IFI6 interferon, alpha-inducible protein 6 -0.0472387
KRT19 keratin 19, type I -0.0469089
HLA-A major histocompatibility complex, class I, A -0.0462683
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0455937
AKAP9 A kinase (PRKA) anchor protein 9 -0.0447687
S100A11 S100 calcium binding protein A11 -0.0423383
RPL34 ribosomal protein L34 -0.0418989
RPL19 ribosomal protein L19 -0.0418364
RPS29 ribosomal protein S29 -0.0417589
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0414949
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0411307
EZR ezrin -0.0409873
MYL12B myosin, light chain 12B, regulatory -0.0404855
KRT8 keratin 8, type II -0.0401539
CEMIP cell migration inducing protein, hyaluronan binding -0.0401036
TMEM123 transmembrane protein 123 -0.0391177
LMO7 LIM domain 7 -0.0382548
HLA-E major histocompatibility complex, class I, E -0.0380595
TPM4 tropomyosin 4 -0.0378253
TMC5 transmembrane channel-like 5 -0.0373824
IFITM3 interferon induced transmembrane protein 3 -0.0371581
GSTP1 glutathione S-transferase pi 1 -0.0362919
H1-0 H1.0 linker histone -0.0359518
RPS24 ribosomal protein S24 -0.0355383
RPL37A ribosomal protein L37a -0.0355081
HLA-B major histocompatibility complex, class I, B -0.0351345
RPS3 ribosomal protein S3 -0.0347639
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.03476
RPL38 ribosomal protein L38 -0.0346552
SLC38A2 solute carrier family 38, member 2 -0.0342491
RPL8 ribosomal protein L8 -0.0340536
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0335882
RPLP2 ribosomal protein, large, P2 -0.0335719
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0335611
LOC102724023 ES1 protein homolog, mitochondrial -0.0334946
RPL26 ribosomal protein L26 -0.0334643
RPL28 ribosomal protein L28 -0.0334258
RB1CC1 RB1-inducible coiled-coil 1 -0.033287
IFITM1 interferon induced transmembrane protein 1 -0.0330603
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0327661
SLC38A1 solute carrier family 38, member 1 -0.0323805
KLK10 kallikrein-related peptidase 10 -0.0323157
RPL36A ribosomal protein L36a -0.0322772
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0322461
LMNA lamin A/C -0.0321107
RPS27A ribosomal protein S27a -0.0319199
TM4SF1 transmembrane 4 L six family member 1 -0.0316824
RPS11 ribosomal protein S11 -0.0312342
DEK DEK proto-oncogene -0.0312253
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310499
H3-3B H3.3 histone B -0.0307631
RPS16 ribosomal protein S16 -0.0306513
TFF2 trefoil factor 2 -0.0304138
HMGB1 high mobility group box 1 -0.0302507
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0301146
LIMA1 LIM domain and actin binding 1 -0.0299663
NDUFA4 NDUFA4, mitochondrial complex associated -0.029634
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0289214
RPS27 ribosomal protein S27 -0.0289023
ITGA6 integrin, alpha 6 -0.02883
SERF2 small EDRK-rich factor 2 -0.0288277
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0286027
PKM pyruvate kinase, muscle -0.0285952
RPL9 ribosomal protein L9 -0.027897
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0278719
KLHL24 kelch-like family member 24 -0.0276211
UBB ubiquitin B -0.0274852
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0273695
JUP junction plakoglobin -0.0267998
CCND1 cyclin D1 -0.0267544