c-Kit-IN-1_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.246144
EXT1 exostosin glycosyltransferase 1 0.118805
DST dystonin 0.115107
TXNRD1 thioredoxin reductase 1 0.100935
RUNX1 runt-related transcription factor 1 0.0971327
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0771174
NAV3 neuron navigator 3 0.0762234
GPHN gephyrin 0.0706691
EEF2 eukaryotic translation elongation factor 2 0.0700927
MCTP1 multiple C2 domains, transmembrane 1 0.0670168
HDAC9 histone deacetylase 9 0.0646288
PTPRG protein tyrosine phosphatase, receptor type, G 0.0618564
SPAG9 sperm associated antigen 9 0.0616183
ASPH aspartate beta-hydroxylase 0.061452
TMPRSS15 transmembrane protease, serine 15 0.0593483
HMGA2 high mobility group AT-hook 2 0.0568516
SAMD4A sterile alpha motif domain containing 4A 0.0567677
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0554511
HOOK2 hook microtubule-tethering protein 2 0.0543604
USP34 ubiquitin specific peptidase 34 0.0536184
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0533195
MYO10 myosin X 0.0529634
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0525664
NUP58 nucleoporin 58 0.0519303
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0508284
UBA6 ubiquitin-like modifier activating enzyme 6 0.0504581
ATP13A3 ATPase type 13A3 0.0499966
PRKCE protein kinase C, epsilon 0.0485176
HSPA8 heat shock 70kDa protein 8 0.0483646
JMJD1C jumonji domain containing 1C 0.0482482
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0481069
PTK2 protein tyrosine kinase 2 0.0479206
DLG1 discs, large homolog 1 (Drosophila) 0.0472148
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0461291
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0460317
NF1 neurofibromin 1 0.0458048
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0451972
PLEC plectin 0.0451214
MSR1 macrophage scavenger receptor 1 0.0446326
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0436529
CORO1C coronin, actin binding protein, 1C 0.0435967
NBAS neuroblastoma amplified sequence 0.0420574
ZFAND3 zinc finger, AN1-type domain 3 0.0420531
LINGO2 leucine rich repeat and Ig domain containing 2 0.0414271
ANK2 ankyrin 2, neuronal 0.0413059
ADAM9 ADAM metallopeptidase domain 9 0.0407772
FNIP1 folliculin interacting protein 1 0.0406878
GLS2 glutaminase 2 (liver, mitochondrial) 0.0406393
CREB5 cAMP responsive element binding protein 5 0.0406016
KMT2C lysine (K)-specific methyltransferase 2C 0.0395628
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0393587
MACF1 microtubule-actin crosslinking factor 1 0.0393359
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0392215
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0390223
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0387876
CXCL8 chemokine (C-X-C motif) ligand 8 0.0383311
ARHGAP32 Rho GTPase activating protein 32 0.0379439
APP amyloid beta (A4) precursor protein 0.0379427
BACE2 beta-site APP-cleaving enzyme 2 0.0378247
PBX3 pre-B-cell leukemia homeobox 3 0.0376734
MYH9 myosin, heavy chain 9, non-muscle 0.0375888
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0373335
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0371617
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0367286
KIAA1217 KIAA1217 0.0364572
WDR43 WD repeat domain 43 0.0360901
MALT1 MALT1 paracaspase 0.0360386
TFRC transferrin receptor 0.0360006
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0357772
SEPTIN10 septin 10 0.035698
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0353465
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0352297
TSC22D2 TSC22 domain family, member 2 0.0349702
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0347464
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0344308
PRRC2C proline-rich coiled-coil 2C 0.0343082
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0341455
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0334062
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0329991
CD109 CD109 molecule 0.0325782
RAB7A RAB7A, member RAS oncogene family 0.0321983
IPO7 importin 7 0.0320475
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0316659
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.03162
GSK3B glycogen synthase kinase 3 beta 0.0314645
FRMD5 FERM domain containing 5 0.0313764
CHD7 chromodomain helicase DNA binding protein 7 0.0310005
GARS1 glycyl-tRNA synthetase 1 0.0303958
GLIS3 GLIS family zinc finger 3 0.030297
COG5 component of oligomeric golgi complex 5 0.0302913
PUM3 pumilio RNA binding family member 3 0.0302766
SATB2 SATB homeobox 2 0.0301156
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0299146
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0297008
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0296219
QKI QKI, KH domain containing, RNA binding 0.0296112
PHF14 PHD finger protein 14 0.0292477
LDHA lactate dehydrogenase A 0.029207
NCKAP1 NCK-associated protein 1 0.0290956
PAWR PRKC, apoptosis, WT1, regulator 0.0289031

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.28399
VIM vimentin -0.197208
TMSB10 thymosin beta 10 -0.116137
RPS27A ribosomal protein S27a -0.0744675
FTL ferritin, light polypeptide -0.0729337
PTMA prothymosin, alpha -0.07168
RPS6 ribosomal protein S6 -0.0682098
ACTG1 actin gamma 1 -0.0673561
MT2A metallothionein 2A -0.0658317
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.062938
UBC ubiquitin C -0.0616289
RPL23 ribosomal protein L23 -0.0560826
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0546528
AHNAK AHNAK nucleoprotein -0.050265
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0472178
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0460537
MMP12 matrix metallopeptidase 12 -0.0460466
RPLP1 ribosomal protein, large, P1 -0.0452621
RPS3 ribosomal protein S3 -0.043237
TPT1 tumor protein, translationally-controlled 1 -0.0426071
LIMCH1 LIM and calponin homology domains 1 -0.0424659
RPS8 ribosomal protein S8 -0.0422089
AKAP12 A kinase (PRKA) anchor protein 12 -0.0410896
KIAA1549L KIAA1549-like -0.0399859
RPLP2 ribosomal protein, large, P2 -0.0395538
NAV1 neuron navigator 1 -0.0387637
PRKG1 protein kinase, cGMP-dependent, type I -0.0375605
PDE4D phosphodiesterase 4D, cAMP-specific -0.0353855
VCL vinculin -0.0335219
FN1 fibronectin 1 -0.0328897
RPL35A ribosomal protein L35a -0.032397
RPL37A ribosomal protein L37a -0.0318651
RPL12 ribosomal protein L12 -0.0317509
PTCHD4 patched domain containing 4 -0.0315885
RPL31 ribosomal protein L31 -0.031543
CDH13 cadherin 13 -0.0306722
RPL26 ribosomal protein L26 -0.0306053
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0303466
RPS12 ribosomal protein S12 -0.029046
RPS19 ribosomal protein S19 -0.0285388
YBX3 Y box binding protein 3 -0.0284881
RPL36 ribosomal protein L36 -0.0273485
FOXP1 forkhead box P1 -0.0268228
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0266334
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0254648
ZBTB20 zinc finger and BTB domain containing 20 -0.024869
NAP1L1 nucleosome assembly protein 1-like 1 -0.024608
RAD51B RAD51 paralog B -0.0242206
RPS13 ribosomal protein S13 -0.0241718
WSB1 WD repeat and SOCS box containing 1 -0.0240839
MYOF myoferlin -0.0239418
RPL19 ribosomal protein L19 -0.0238705
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0236028
TENM2 teneurin transmembrane protein 2 -0.0229421
SMAD3 SMAD family member 3 -0.0228129
SLC38A2 solute carrier family 38, member 2 -0.0227335
RPL28 ribosomal protein L28 -0.0226147
RPL8 ribosomal protein L8 -0.0224228
RPL36A ribosomal protein L36a -0.0220266
RPL34 ribosomal protein L34 -0.0219619
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0219461
RPS29 ribosomal protein S29 -0.0218556
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0217682
RNF213 ring finger protein 213 -0.0216691
DNER delta/notch-like EGF repeat containing -0.0215736
BTG1 B-cell translocation gene 1, anti-proliferative -0.0214958
RPS21 ribosomal protein S21 -0.0214811
RBM39 RNA binding motif protein 39 -0.0211167
OGA O-GlcNAcase -0.0208496
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0206106
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0205773
RB1CC1 RB1-inducible coiled-coil 1 -0.0204071
RPS23 ribosomal protein S23 -0.0203024
TM4SF1 transmembrane 4 L six family member 1 -0.0202093
RPS25 ribosomal protein S25 -0.0201136
RPS17 ribosomal protein S17 -0.0200961
EGFR epidermal growth factor receptor -0.0198216
RPS24 ribosomal protein S24 -0.0198069
RPL13A ribosomal protein L13a -0.019696
RPL9 ribosomal protein L9 -0.0195283
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0190924
NDRG1 N-myc downstream regulated 1 -0.0186858
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.018306
RPS5 ribosomal protein S5 -0.0182985
RPS20 ribosomal protein S20 -0.0181248
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0177408
TPI1 triosephosphate isomerase 1 -0.0175882
CAVIN1 caveolae associated protein 1 -0.0175622
RPLP0 ribosomal protein, large, P0 -0.0174677
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0174488
EGR1 early growth response 1 -0.0173718
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0172324
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0171968
NALF1 NALCN channel auxiliary factor 1 -0.0169155
MYL12B myosin, light chain 12B, regulatory -0.0168533
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0167658
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0167284
POTEF POTE ankyrin domain family, member F -0.016433
RPL5 ribosomal protein L5 -0.016312
RPS14 ribosomal protein S14 -0.0162178