c-Kit-IN-1_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase 0.127542
EEF2 eukaryotic translation elongation factor 2 0.103224
EXT1 exostosin glycosyltransferase 1 0.10037
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0967032
LDHA lactate dehydrogenase A 0.093788
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0762484
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0752483
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0720046
ASPH aspartate beta-hydroxylase 0.0673501
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0671386
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0654278
MYH9 myosin, heavy chain 9, non-muscle 0.0647986
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0645643
PTEN phosphatase and tensin homolog 0.0640321
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0638446
NUP58 nucleoporin 58 0.0627038
SRRM2 serine/arginine repetitive matrix 2 0.0626457
PABPC1 poly(A) binding protein, cytoplasmic 1 0.062465
KRT8 keratin 8, type II 0.0582281
ZFAND3 zinc finger, AN1-type domain 3 0.0569546
MYO5B myosin VB 0.0552265
ARHGAP26 Rho GTPase activating protein 26 0.0547887
GSK3B glycogen synthase kinase 3 beta 0.0540365
COG5 component of oligomeric golgi complex 5 0.0536711
HSPA8 heat shock 70kDa protein 8 0.0528587
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0528559
PDZD8 PDZ domain containing 8 0.0523829
PCBP2 poly(rC) binding protein 2 0.0514278
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0510258
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0510104
PRRC2C proline-rich coiled-coil 2C 0.0507768
AKAP13 A kinase (PRKA) anchor protein 13 0.0507015
SMYD3 SET and MYND domain containing 3 0.0500897
KRT18 keratin 18, type I 0.0493348
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0477427
PRELID2 PRELI domain containing 2 0.0476887
UBA6 ubiquitin-like modifier activating enzyme 6 0.0476708
NBAS neuroblastoma amplified sequence 0.047644
MED13 mediator complex subunit 13 0.0473019
VEGFA vascular endothelial growth factor A 0.0470911
LPP LIM domain containing preferred translocation partner in lipoma 0.0462042
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0458065
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0452236
SIK3 SIK family kinase 3 0.0451544
SFPQ splicing factor proline/glutamine-rich 0.0443621
NEBL nebulette 0.0437767
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0436643
SAMD4A sterile alpha motif domain containing 4A 0.043075
EPS8 epidermal growth factor receptor pathway substrate 8 0.043045
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0429803
KDM4C lysine (K)-specific demethylase 4C 0.0428137
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0425039
MACF1 microtubule-actin crosslinking factor 1 0.0424051
TRIO trio Rho guanine nucleotide exchange factor 0.0414968
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0413636
FHIT fragile histidine triad 0.0411276
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0410623
USP9X ubiquitin specific peptidase 9, X-linked 0.0405972
ANKRD11 ankyrin repeat domain 11 0.0404965
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.040432
DLG1 discs, large homolog 1 (Drosophila) 0.0404112
ANKRD17 ankyrin repeat domain 17 0.0401978
PARD3B par-3 family cell polarity regulator beta 0.0400774
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0400671
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0400315
TFRC transferrin receptor 0.0388458
ATXN1 ataxin 1 0.0383735
VCL vinculin 0.0382849
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0375225
RPL3 ribosomal protein L3 0.0373639
NCKAP1 NCK-associated protein 1 0.0371163
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0369218
PTBP3 polypyrimidine tract binding protein 3 0.0368941
GOLGA4 golgin A4 0.0368486
PSAT1 phosphoserine aminotransferase 1 0.0368483
PICALM phosphatidylinositol binding clathrin assembly protein 0.036544
CLTC clathrin, heavy chain (Hc) 0.0364715
GLS2 glutaminase 2 (liver, mitochondrial) 0.0361035
RNF145 ring finger protein 145 0.0359904
CARD16 caspase recruitment domain family, member 16 0.0359802
ARL15 ADP-ribosylation factor-like 15 0.0358734
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0356016
CLCN3 chloride channel, voltage-sensitive 3 0.0353476
CSNK1A1 casein kinase 1, alpha 1 0.0349442
MACC1 metastasis associated in colon cancer 1 0.034886
UBE2H ubiquitin-conjugating enzyme E2H 0.0348317
USP34 ubiquitin specific peptidase 34 0.034724
ACTN4 actinin, alpha 4 0.0345277
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0344864
FNIP1 folliculin interacting protein 1 0.0341975
PNN pinin, desmosome associated protein 0.0341866
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0340394
KMT2C lysine (K)-specific methyltransferase 2C 0.0339659
VMP1 vacuole membrane protein 1 0.0338567
GARS1 glycyl-tRNA synthetase 1 0.033639
WAC WW domain containing adaptor with coiled-coil 0.033124
TRIM2 tripartite motif containing 2 0.0329567
TPD52 tumor protein D52 0.0328897
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.03288
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0327224

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.172051
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.167923
NPSR1 neuropeptide S receptor 1 -0.152834
TPT1 tumor protein, translationally-controlled 1 -0.148954
RPS6 ribosomal protein S6 -0.117627
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0997254
PTMA prothymosin, alpha -0.0895455
RPLP1 ribosomal protein, large, P1 -0.0771987
GCC2 GRIP and coiled-coil domain containing 2 -0.0709415
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0692596
FTL ferritin, light polypeptide -0.0667684
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0632662
AGR2 anterior gradient 2 -0.0571072
EZR ezrin -0.0537743
RPS8 ribosomal protein S8 -0.0537375
GDF15 growth differentiation factor 15 -0.0504926
TMSB10 thymosin beta 10 -0.0498863
RPS27A ribosomal protein S27a -0.0466732
ANXA2 annexin A2 -0.0459984
ANTXR2 anthrax toxin receptor 2 -0.0441254
RPS27 ribosomal protein S27 -0.0437732
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0420695
RPS12 ribosomal protein S12 -0.0420394
TPM4 tropomyosin 4 -0.0403858
RPL13A ribosomal protein L13a -0.0389899
FERMT1 fermitin family member 1 -0.0388852
PRSS3 protease, serine, 3 -0.0385522
BTG1 B-cell translocation gene 1, anti-proliferative -0.0383113
RPLP2 ribosomal protein, large, P2 -0.0366365
RPL31 ribosomal protein L31 -0.036405
RPS29 ribosomal protein S29 -0.0363321
ITGB4 integrin, beta 4 -0.0350049
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338578
RNF217 ring finger protein 217 -0.033199
RPL34 ribosomal protein L34 -0.0315885
RPS13 ribosomal protein S13 -0.0313226
RPS3 ribosomal protein S3 -0.0311747
RPL12 ribosomal protein L12 -0.0310085
MT2A metallothionein 2A -0.0307706
VDAC1 voltage-dependent anion channel 1 -0.0306604
NALF1 NALCN channel auxiliary factor 1 -0.0297876
RPL36 ribosomal protein L36 -0.0296756
RPL26 ribosomal protein L26 -0.0295398
KLF5 Kruppel-like factor 5 (intestinal) -0.0294084
B2M beta-2-microglobulin -0.0292535
FTH1 ferritin, heavy polypeptide 1 -0.0288337
RPL35A ribosomal protein L35a -0.0286413
S100A6 S100 calcium binding protein A6 -0.0285635
TNS4 tensin 4 -0.0282934
PNISR PNN-interacting serine/arginine-rich protein -0.0282865
RPS25 ribosomal protein S25 -0.0277173
ISG15 ISG15 ubiquitin-like modifier -0.0271522
SOX4 SRY (sex determining region Y)-box 4 -0.026857
MAML2 mastermind-like 2 (Drosophila) -0.0258447
ZNF33A zinc finger protein 33A -0.0258146
RIN2 Ras and Rab interactor 2 -0.0254983
GNAS GNAS complex locus -0.0252079
RPS19 ribosomal protein S19 -0.0250806
RPL38 ribosomal protein L38 -0.0243823
PPARG peroxisome proliferator-activated receptor gamma -0.0241897
IER3 immediate early response 3 -0.0240728
KLF3 Kruppel-like factor 3 (basic) -0.0240693
RPS23 ribosomal protein S23 -0.024036
ZBTB20 zinc finger and BTB domain containing 20 -0.0236157
GTF2IRD1 GTF2I repeat domain containing 1 -0.0235212
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0229573
AHNAK AHNAK nucleoprotein -0.0229398
TMEM45B transmembrane protein 45B -0.0228313
DYNC2I1 dynein 2 intermediate chain 1 -0.0227858
S100A9 S100 calcium binding protein A9 -0.0227505
MYO1E myosin IE -0.0224605
CCND1 cyclin D1 -0.0224375
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0220413
SMIM14 small integral membrane protein 14 -0.0220332
RPL37 ribosomal protein L37 -0.0219628
RRBP1 ribosome binding protein 1 -0.0219279
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0218797
RPS16 ribosomal protein S16 -0.0218053
HBP1 HMG-box transcription factor 1 -0.0215697
RPS14 ribosomal protein S14 -0.02155
FNBP1L formin binding protein 1-like -0.0215176
KIF5B kinesin family member 5B -0.0214744
AHI1 Abelson helper integration site 1 -0.0214007
PHF3 PHD finger protein 3 -0.0213137
FBXO32 F-box protein 32 -0.0212528
KLHL24 kelch-like family member 24 -0.021103
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0209409
ADD3 adducin 3 (gamma) -0.0209014
RPL27A ribosomal protein L27a -0.0208875
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0206208
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0205297
GREB1L growth regulation by estrogen in breast cancer-like -0.0202246
RB1CC1 RB1-inducible coiled-coil 1 -0.0201034
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0195933
RPL9 ribosomal protein L9 -0.0194791
ANAPC5 anaphase promoting complex subunit 5 -0.0194765
FBXL20 F-box and leucine-rich repeat protein 20 -0.0194181
RPS24 ribosomal protein S24 -0.0193194
HMGB1 high mobility group box 1 -0.0193183
BZW1 basic leucine zipper and W2 domains 1 -0.0193087