c-Kit-IN-1_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FRMD5 FERM domain containing 5 0.101857
GMDS GDP-mannose 4,6-dehydratase 0.0981537
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0956355
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.092226
ZFAND3 zinc finger, AN1-type domain 3 0.0803834
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0792006
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0789901
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0774675
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0722722
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0704097
NAMPT nicotinamide phosphoribosyltransferase 0.0658522
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0639642
HSPA8 heat shock 70kDa protein 8 0.0635442
COG5 component of oligomeric golgi complex 5 0.0625557
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0622156
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0616164
SND1 staphylococcal nuclease and tudor domain containing 1 0.0610279
LDHA lactate dehydrogenase A 0.0593553
EEF2 eukaryotic translation elongation factor 2 0.0592557
TXNRD1 thioredoxin reductase 1 0.0574434
TRIO trio Rho guanine nucleotide exchange factor 0.0540238
NUP58 nucleoporin 58 0.0534024
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0517147
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0516318
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0513296
PABPC1 poly(A) binding protein, cytoplasmic 1 0.050999
MSI2 musashi RNA-binding protein 2 0.0506863
PRELID2 PRELI domain containing 2 0.0502911
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0502228
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0498784
ASPH aspartate beta-hydroxylase 0.0496261
MYO5B myosin VB 0.0493273
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0484244
PCBP2 poly(rC) binding protein 2 0.0474677
DENND1A DENN/MADD domain containing 1A 0.0473881
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0468576
PTK2 protein tyrosine kinase 2 0.0465001
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.046288
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0461407
KMT2C lysine (K)-specific methyltransferase 2C 0.0457113
TAS2R14 taste receptor, type 2, member 14 0.0448529
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0447384
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0443139
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0441317
GSK3B glycogen synthase kinase 3 beta 0.043893
NPTN neuroplastin 0.0433132
PRRC2C proline-rich coiled-coil 2C 0.0432053
ZFC3H1 zinc finger, C3H1-type containing 0.0428167
FAF1 Fas (TNFRSF6) associated factor 1 0.0423851
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0423052
MAP2K1 mitogen-activated protein kinase kinase 1 0.042143
CANX calnexin 0.0416779
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0416021
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0414143
ANO6 anoctamin 6 0.041362
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0410087
OLA1 Obg-like ATPase 1 0.0408717
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0407143
FNIP1 folliculin interacting protein 1 0.040659
DLG1 discs, large homolog 1 (Drosophila) 0.0400212
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0399446
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.039582
USP34 ubiquitin specific peptidase 34 0.0393141
TNPO1 transportin 1 0.0391139
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.038898
UPP1 uridine phosphorylase 1 0.0388148
GPHN gephyrin 0.038591
ZNF292 zinc finger protein 292 0.03821
MAP4 microtubule-associated protein 4 0.0376703
APP amyloid beta (A4) precursor protein 0.0375513
PDE8A phosphodiesterase 8A 0.0373064
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0367969
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0367327
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0366091
GARS1 glycyl-tRNA synthetase 1 0.0363251
SRRM2 serine/arginine repetitive matrix 2 0.0359575
NHSL1 NHS-like 1 0.0358955
GRB10 growth factor receptor-bound protein 10 0.0358496
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0357469
ANKRD17 ankyrin repeat domain 17 0.0357418
ITPRID2 ITPR interacting domain containing 2 0.0351592
TCF12 transcription factor 12 0.0351118
BIRC6 baculoviral IAP repeat containing 6 0.0349409
SAMD5 sterile alpha motif domain containing 5 0.0346179
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0344771
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0342773
EIF4B eukaryotic translation initiation factor 4B 0.0339356
USP3 ubiquitin specific peptidase 3 0.03371
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0335192
XPO1 exportin 1 0.0332722
GCLC glutamate-cysteine ligase, catalytic subunit 0.0332536
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0330829
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0327089
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0326923
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.032634
JMJD1C jumonji domain containing 1C 0.032569
UST uronyl-2-sulfotransferase 0.0324593
NAP1L1 nucleosome assembly protein 1-like 1 0.0321872
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0320191
CLTC clathrin, heavy chain (Hc) 0.0320058

decreased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 -0.139537
RPLP1 ribosomal protein, large, P1 -0.0884905
RPS12 ribosomal protein S12 -0.0858628
LMO7 LIM domain 7 -0.0839961
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0811264
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0783217
TPT1 tumor protein, translationally-controlled 1 -0.0739709
PTPRR protein tyrosine phosphatase, receptor type, R -0.0693342
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0689188
RPS8 ribosomal protein S8 -0.0685798
RPL37A ribosomal protein L37a -0.0598859
RPLP2 ribosomal protein, large, P2 -0.0598329
PLAC8 placenta-specific 8 -0.0564974
SHROOM3 shroom family member 3 -0.0557617
MYOF myoferlin -0.0555692
RPS23 ribosomal protein S23 -0.0553292
AKAP9 A kinase (PRKA) anchor protein 9 -0.0548094
RPS3 ribosomal protein S3 -0.05447
RPL31 ribosomal protein L31 -0.0538222
HLA-B major histocompatibility complex, class I, B -0.0520264
RPS29 ribosomal protein S29 -0.0512432
TMSB10 thymosin beta 10 -0.0505174
RPS13 ribosomal protein S13 -0.0505063
FAT1 FAT atypical cadherin 1 -0.0501812
RPL19 ribosomal protein L19 -0.0501692
ITGA6 integrin, alpha 6 -0.0485363
RPS19 ribosomal protein S19 -0.0473075
FTH1 ferritin, heavy polypeptide 1 -0.0453465
RPS27A ribosomal protein S27a -0.0443129
RPL11 ribosomal protein L11 -0.0433068
RPL13A ribosomal protein L13a -0.0417228
RPL36 ribosomal protein L36 -0.0412651
VCL vinculin -0.0407265
RPL12 ribosomal protein L12 -0.0397497
RPS27 ribosomal protein S27 -0.0392696
THSD4 thrombospondin, type I, domain containing 4 -0.0391777
RPL35A ribosomal protein L35a -0.0387887
RPL9 ribosomal protein L9 -0.0387298
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0377424
RPL26 ribosomal protein L26 -0.0373746
RPS11 ribosomal protein S11 -0.0371021
RPS17 ribosomal protein S17 -0.037094
RPS14 ribosomal protein S14 -0.0367147
TNRC18 trinucleotide repeat containing 18 -0.0359046
RPS25 ribosomal protein S25 -0.0354856
PKP2 plakophilin 2 -0.0325641
RPL8 ribosomal protein L8 -0.0325542
RPL34 ribosomal protein L34 -0.0321448
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0319871
RACK1 receptor for activated C kinase 1 -0.0318573
FOXO1 forkhead box O1 -0.0315755
TRIM2 tripartite motif containing 2 -0.0315214
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0315183
RPL28 ribosomal protein L28 -0.0314206
IFI6 interferon, alpha-inducible protein 6 -0.0307077
MYO1E myosin IE -0.0301686
RPL23 ribosomal protein L23 -0.0301048
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0300476
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0299142
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0297029
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.029056
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.028773
RPS15 ribosomal protein S15 -0.0286768
FOXP1 forkhead box P1 -0.0283478
CLDN4 claudin 4 -0.027635
MX2 MX dynamin-like GTPase 2 -0.0271944
KLF3 Kruppel-like factor 3 (basic) -0.0271361
SP100 SP100 nuclear antigen -0.0271024
RPS2 ribosomal protein S2 -0.0270168
FTL ferritin, light polypeptide -0.0267002
RPS5 ribosomal protein S5 -0.0263642
RPLP0 ribosomal protein, large, P0 -0.0260707
PTMA prothymosin, alpha -0.0260476
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0259345
RPS21 ribosomal protein S21 -0.0259231
JMY junction mediating and regulatory protein, p53 cofactor -0.0255367
TMEM45B transmembrane protein 45B -0.0253829
RB1CC1 RB1-inducible coiled-coil 1 -0.0251488
GCC2 GRIP and coiled-coil domain containing 2 -0.0248813
MT2A metallothionein 2A -0.0247413
RIGI RNA sensor RIG-I -0.0244277
P3H2 prolyl 3-hydroxylase 2 -0.0242326
TRIM31 tripartite motif containing 31 -0.0241005
ACTG1 actin gamma 1 -0.0239897
LIMA1 LIM domain and actin binding 1 -0.0239156
PTPRB protein tyrosine phosphatase, receptor type, B -0.0238099
CALB1 calbindin 1, 28kDa -0.0236526
TSPAN8 tetraspanin 8 -0.0236225
ZBTB20 zinc finger and BTB domain containing 20 -0.0226436
NT5C2 5'-nucleotidase, cytosolic II -0.0225982
PRSS3 protease, serine, 3 -0.0223895
TLN2 talin 2 -0.0223722
RPL35 ribosomal protein L35 -0.0221273
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0219293
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0218555
RPS20 ribosomal protein S20 -0.0217642
CEMIP cell migration inducing protein, hyaluronan binding -0.0216989
RIN2 Ras and Rab interactor 2 -0.0215906
GDF15 growth differentiation factor 15 -0.0213088
GOLGB1 golgin B1 -0.0212382