c-Kit-IN-1_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.122057
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.085911
HOOK2 hook microtubule-tethering protein 2 0.0803437
ERRFI1 ERBB receptor feedback inhibitor 1 0.0681313
SPAG9 sperm associated antigen 9 0.0624489
GARS1 glycyl-tRNA synthetase 1 0.0611507
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0609739
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0593421
EEF2 eukaryotic translation elongation factor 2 0.0568575
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0527046
NAMPT nicotinamide phosphoribosyltransferase 0.0525996
ZFAND3 zinc finger, AN1-type domain 3 0.0508311
ANK2 ankyrin 2, neuronal 0.0507535
RAI1 retinoic acid induced 1 0.0464998
DLG1 discs, large homolog 1 (Drosophila) 0.0461831
ATP13A3 ATPase type 13A3 0.0461728
NBAS neuroblastoma amplified sequence 0.045872
NUP58 nucleoporin 58 0.0455583
EREG epiregulin 0.045554
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0445348
KMT2E lysine (K)-specific methyltransferase 2E 0.0439246
APP amyloid beta (A4) precursor protein 0.0429084
ADAM17 ADAM metallopeptidase domain 17 0.0427866
BIRC6 baculoviral IAP repeat containing 6 0.0419635
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0405576
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0401901
KMT2C lysine (K)-specific methyltransferase 2C 0.039924
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391668
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0388739
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0382402
USP34 ubiquitin specific peptidase 34 0.0373333
DST dystonin 0.0369257
EZR ezrin 0.036822
TMEM41B transmembrane protein 41B 0.0365634
CHD7 chromodomain helicase DNA binding protein 7 0.0364521
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0364036
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0362486
FNIP1 folliculin interacting protein 1 0.0354021
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0350847
TRIP12 thyroid hormone receptor interactor 12 0.0350207
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0348998
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0346975
FMNL2 formin-like 2 0.0345424
XPO1 exportin 1 0.0342054
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0337145
ANKRD11 ankyrin repeat domain 11 0.0335917
TFRC transferrin receptor 0.0333444
POM121 POM121 transmembrane nucleoporin 0.0329156
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0324579
PUM1 pumilio RNA-binding family member 1 0.0321856
YEATS2 YEATS domain containing 2 0.0319645
MDN1 MDN1, midasin homolog (yeast) 0.0318779
SEC24A SEC24 family member A 0.0316821
CLTC clathrin, heavy chain (Hc) 0.0316421
ZEB1 zinc finger E-box binding homeobox 1 0.0314598
IPO7 importin 7 0.0313957
CAPRIN2 caprin family member 2 0.0312446
CHD1 chromodomain helicase DNA binding protein 1 0.0309343
ANXA1 annexin A1 0.0307929
SRRM2 serine/arginine repetitive matrix 2 0.0307711
IARS1 isoleucyl-tRNA synthetase 1 0.0306671
GMDS GDP-mannose 4,6-dehydratase 0.029956
PRRC2C proline-rich coiled-coil 2C 0.0298757
RTN4 reticulon 4 0.0297825
COG5 component of oligomeric golgi complex 5 0.0297131
SFPQ splicing factor proline/glutamine-rich 0.0296049
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0295457
AHCTF1 AT hook containing transcription factor 1 0.0294694
OLA1 Obg-like ATPase 1 0.0294077
JMJD1C jumonji domain containing 1C 0.0292646
PUM2 pumilio RNA-binding family member 2 0.0291418
MEMO1 mediator of cell motility 1 0.0290932
ECPAS Ecm29 proteasome adaptor and scaffold 0.0289802
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0288812
MACF1 microtubule-actin crosslinking factor 1 0.0287951
FAR1 fatty acyl CoA reductase 1 0.0284819
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0283558
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0278388
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0278162
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0278047
AFF4 AF4/FMR2 family, member 4 0.0276783
NCKAP1 NCK-associated protein 1 0.0276487
WDR43 WD repeat domain 43 0.0275646
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0275057
ANLN anillin, actin binding protein 0.0263945
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0261081
ADAM9 ADAM metallopeptidase domain 9 0.0260944
CKAP5 cytoskeleton associated protein 5 0.0260589
GPHN gephyrin 0.0259754
KCMF1 potassium channel modulatory factor 1 0.0257964
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0257816
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0257448
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0253347
TNPO1 transportin 1 0.0253046
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0252939
CEP170 centrosomal protein 170kDa 0.0251286
ESYT2 extended synaptotagmin-like protein 2 0.0249469
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0247295
KDM3A lysine (K)-specific demethylase 3A 0.0246972
SPIRE1 spire-type actin nucleation factor 1 0.0246944

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.197864
TP63 tumor protein p63 -0.133591
RPS6 ribosomal protein S6 -0.095559
RPS8 ribosomal protein S8 -0.0867187
CD44 CD44 molecule (Indian blood group) -0.083334
RPS12 ribosomal protein S12 -0.0813667
RPL37A ribosomal protein L37a -0.0793433
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0755523
CADM2 cell adhesion molecule 2 -0.0743016
RPL12 ribosomal protein L12 -0.0734711
RPL31 ribosomal protein L31 -0.0693458
RPL35A ribosomal protein L35a -0.0685785
FTL ferritin, light polypeptide -0.0666731
RPL26 ribosomal protein L26 -0.0647602
HLA-B major histocompatibility complex, class I, B -0.0642069
RAD51B RAD51 paralog B -0.0636576
PTMA prothymosin, alpha -0.0636215
RPS19 ribosomal protein S19 -0.063552
RPLP2 ribosomal protein, large, P2 -0.0624737
MT2A metallothionein 2A -0.0587699
TPT1 tumor protein, translationally-controlled 1 -0.0587375
RPS3 ribosomal protein S3 -0.057772
PSD3 pleckstrin and Sec7 domain containing 3 -0.055113
RPS23 ribosomal protein S23 -0.0531885
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0516266
RPS29 ribosomal protein S29 -0.0515546
RPL36 ribosomal protein L36 -0.0510865
RIGI RNA sensor RIG-I -0.0503102
RPS27A ribosomal protein S27a -0.0500808
TMSB10 thymosin beta 10 -0.0464943
RPS13 ribosomal protein S13 -0.0461875
RPS27 ribosomal protein S27 -0.044582
RPL23 ribosomal protein L23 -0.0429174
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0418409
RPL38 ribosomal protein L38 -0.0402528
RPL11 ribosomal protein L11 -0.0399139
RPL28 ribosomal protein L28 -0.0395256
SP100 SP100 nuclear antigen -0.0394652
CFAP299 cilia and flagella associated protein 299 -0.0389945
RPS10 ribosomal protein S10 -0.0386792
RPL19 ribosomal protein L19 -0.0386125
RPS17 ribosomal protein S17 -0.0377555
RPL13A ribosomal protein L13a -0.0366774
RPL35 ribosomal protein L35 -0.0361491
DPH6 diphthamine biosynthesis 6 -0.0358886
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0356141
PRELID2 PRELI domain containing 2 -0.0355546
IFI6 interferon, alpha-inducible protein 6 -0.035447
RACK1 receptor for activated C kinase 1 -0.0349331
STAT1 signal transducer and activator of transcription 1, 91kDa -0.03426
RPLP1 ribosomal protein, large, P1 -0.0338417
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0328072
RNF213 ring finger protein 213 -0.0325981
RPS25 ribosomal protein S25 -0.0324831
ACTG1 actin gamma 1 -0.0324683
RPS24 ribosomal protein S24 -0.032324
RPS21 ribosomal protein S21 -0.0322797
RPS14 ribosomal protein S14 -0.032225
RPL37 ribosomal protein L37 -0.0320958
EHBP1 EH domain binding protein 1 -0.032077
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0316298
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0311133
RPL36A ribosomal protein L36a -0.0311092
PLSCR1 phospholipid scramblase 1 -0.0309193
NT5E 5'-nucleotidase, ecto (CD73) -0.0304768
RPL27 ribosomal protein L27 -0.0302408
RPL8 ribosomal protein L8 -0.0299756
NEK10 NIMA-related kinase 10 -0.0296116
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0295284
VCL vinculin -0.0291973
RPS20 ribosomal protein S20 -0.0289211
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0286829
PDE10A phosphodiesterase 10A -0.0280567
RPS15 ribosomal protein S15 -0.0279909
RPL34 ribosomal protein L34 -0.0278138
IFIH1 interferon induced with helicase C domain 1 -0.0276428
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0267703
RPS11 ribosomal protein S11 -0.0266158
VIM vimentin -0.0259035
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0256729
PMP22 peripheral myelin protein 22 -0.0248614
RPL9 ribosomal protein L9 -0.0239533
DPYD dihydropyrimidine dehydrogenase -0.0234384
B2M beta-2-microglobulin -0.0233113
HLA-A major histocompatibility complex, class I, A -0.0232318
RPLP0 ribosomal protein, large, P0 -0.0227628
RPS2 ribosomal protein S2 -0.0226912
EXOC4 exocyst complex component 4 -0.0224546
TNS3 tensin 3 -0.0222718
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0221892
BICD1 bicaudal D homolog 1 (Drosophila) -0.0215913
RPL18 ribosomal protein L18 -0.0214381
RPL27A ribosomal protein L27a -0.0213429
RPS5 ribosomal protein S5 -0.0206054
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0202836
TPI1 triosephosphate isomerase 1 -0.0198208
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0195472
TRIM56 tripartite motif containing 56 -0.0189716
DNAH14 dynein, axonemal, heavy chain 14 -0.0187518
RPL7A ribosomal protein L7a -0.0187397