c-Kit-IN-1_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SLTM SAFB-like, transcription modulator 0.193876
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.127067
GPC6 glypican 6 0.100132
DTNA dystrobrevin, alpha 0.0983391
SOD2 superoxide dismutase 2, mitochondrial 0.0811424
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0776068
CXCL8 chemokine (C-X-C motif) ligand 8 0.0729404
RUNX1 runt-related transcription factor 1 0.0718393
SEPTIN10 septin 10 0.0676106
MCTP1 multiple C2 domains, transmembrane 1 0.0604319
HOOK2 hook microtubule-tethering protein 2 0.0601757
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0563988
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0557208
NAMPT nicotinamide phosphoribosyltransferase 0.0544258
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.054079
FNIP1 folliculin interacting protein 1 0.0534289
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0520482
NPTN neuroplastin 0.0497031
SRRM2 serine/arginine repetitive matrix 2 0.0479878
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.047076
GSK3B glycogen synthase kinase 3 beta 0.0469077
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0452697
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0443586
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.044275
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.043854
FAT1 FAT atypical cadherin 1 0.043244
GLS2 glutaminase 2 (liver, mitochondrial) 0.0424274
SAMD4A sterile alpha motif domain containing 4A 0.0421801
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0414964
CES1 carboxylesterase 1 0.0411977
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0411327
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0408168
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0403542
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0385432
NGLY1 N-glycanase 1 0.0384372
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0378648
MYH9 myosin, heavy chain 9, non-muscle 0.0377905
NBAS neuroblastoma amplified sequence 0.0377312
USP34 ubiquitin specific peptidase 34 0.0374981
MACF1 microtubule-actin crosslinking factor 1 0.0373326
PLEC plectin 0.0372989
YEATS2 YEATS domain containing 2 0.0370693
GCLC glutamate-cysteine ligase, catalytic subunit 0.0370114
EEF2 eukaryotic translation elongation factor 2 0.0369621
LRP12 low density lipoprotein receptor-related protein 12 0.0366338
PRELID2 PRELI domain containing 2 0.036573
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0353499
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0350077
ANXA5 annexin A5 0.0349867
SPAG9 sperm associated antigen 9 0.0348337
SMAD3 SMAD family member 3 0.0341404
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0338547
TBC1D22A TBC1 domain family, member 22A 0.0335745
ANO6 anoctamin 6 0.033552
PDZD8 PDZ domain containing 8 0.0334233
GPHN gephyrin 0.0330805
MCL1 myeloid cell leukemia 1 0.0319782
HSPA8 heat shock 70kDa protein 8 0.0316185
FNDC3B fibronectin type III domain containing 3B 0.0311985
CD109 CD109 molecule 0.0309672
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0308432
TSC22D2 TSC22 domain family, member 2 0.0307024
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0305124
BACE2 beta-site APP-cleaving enzyme 2 0.0301263
PCBP2 poly(rC) binding protein 2 0.0296312
GPATCH2L G patch domain containing 2-like 0.0292833
ARRDC3 arrestin domain containing 3 0.0289131
TPD52 tumor protein D52 0.0287638
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0287235
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) 0.0286476
MYO1B myosin IB 0.0285625
ELL2 elongation factor, RNA polymerase II, 2 0.0284734
PTK2 protein tyrosine kinase 2 0.0284686
BIRC3 baculoviral IAP repeat containing 3 0.0284195
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0281105
COG5 component of oligomeric golgi complex 5 0.0279943
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0279515
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0278957
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0278724
EGFR epidermal growth factor receptor 0.0278133
EXT1 exostosin glycosyltransferase 1 0.0274291
ZNF638 zinc finger protein 638 0.0272265
SFPQ splicing factor proline/glutamine-rich 0.0270297
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0269396
FBXL5 F-box and leucine-rich repeat protein 5 0.0266559
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0265375
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0262605
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0262224
FRMD5 FERM domain containing 5 0.0261001
ANKRD17 ankyrin repeat domain 17 0.0256446
UBA6 ubiquitin-like modifier activating enzyme 6 0.0255938
SNX9 sorting nexin 9 0.0254921
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0252855
LOC112694756 uncharaterized LOC112694756 0.0251971
ATP13A3 ATPase type 13A3 0.0250641
BRWD3 bromodomain and WD repeat domain containing 3 0.0249152
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0247714
ADAM9 ADAM metallopeptidase domain 9 0.0246696
CCSER1 coiled-coil serine-rich protein 1 0.024664
CANX calnexin 0.0246078

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.304297
TMSB10 thymosin beta 10 -0.142181
LMO7 LIM domain 7 -0.0959779
TPT1 tumor protein, translationally-controlled 1 -0.0798855
ASPH aspartate beta-hydroxylase -0.0790943
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0765653
FTL ferritin, light polypeptide -0.0759559
PTMA prothymosin, alpha -0.0693074
ACTG1 actin gamma 1 -0.0641483
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0636974
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0596506
PDE4D phosphodiesterase 4D, cAMP-specific -0.0576195
MT2A metallothionein 2A -0.0547063
S100A10 S100 calcium binding protein A10 -0.0543923
RPLP1 ribosomal protein, large, P1 -0.0536703
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.053028
CAV1 caveolin 1, caveolae protein, 22kDa -0.0520564
PTPRM protein tyrosine phosphatase, receptor type, M -0.0505306
ZBTB20 zinc finger and BTB domain containing 20 -0.0504742
RPS3 ribosomal protein S3 -0.0480426
RPS6 ribosomal protein S6 -0.0444331
RPS8 ribosomal protein S8 -0.0443598
RPL35A ribosomal protein L35a -0.0438797
TXNRD1 thioredoxin reductase 1 -0.0421346
THSD4 thrombospondin, type I, domain containing 4 -0.0403126
BTG1 B-cell translocation gene 1, anti-proliferative -0.0388525
H1-0 H1.0 linker histone -0.0381363
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0374331
WASF2 WAS protein family, member 2 -0.036679
KRT7 keratin 7, type II -0.0359568
RPS25 ribosomal protein S25 -0.0352782
RPS27A ribosomal protein S27a -0.034424
CST3 cystatin C -0.0336748
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0329271
RPL12 ribosomal protein L12 -0.0324276
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0320563
RPS29 ribosomal protein S29 -0.0318745
RPL31 ribosomal protein L31 -0.0316535
ZMYND8 zinc finger, MYND-type containing 8 -0.0314842
AKR1C1 aldo-keto reductase family 1, member C1 -0.0313998
TNRC6B trinucleotide repeat containing 6B -0.0309549
RPS24 ribosomal protein S24 -0.030028
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0292538
RPLP0 ribosomal protein, large, P0 -0.0289675
RPS12 ribosomal protein S12 -0.0287325
RPS23 ribosomal protein S23 -0.0286876
RPL34 ribosomal protein L34 -0.0286677
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0280347
PARD3 par-3 family cell polarity regulator -0.0277621
CPE carboxypeptidase E -0.0273057
BBX bobby sox homolog (Drosophila) -0.0271538
OGA O-GlcNAcase -0.0269261
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0268891
KRT18 keratin 18, type I -0.0264572
RIMS2 regulating synaptic membrane exocytosis 2 -0.0262938
RPLP2 ribosomal protein, large, P2 -0.0260775
FTH1 ferritin, heavy polypeptide 1 -0.0260727
RPL19 ribosomal protein L19 -0.0259274
PKM pyruvate kinase, muscle -0.0253313
AHNAK AHNAK nucleoprotein -0.0252933
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0252675
SCEL sciellin -0.025158
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0251336
NABP1 nucleic acid binding protein 1 -0.0248339
HBP1 HMG-box transcription factor 1 -0.0248101
SEC61G Sec61 gamma subunit -0.0239131
MAML3 mastermind-like 3 (Drosophila) -0.0239059
S100P S100 calcium binding protein P -0.0235705
CCND1 cyclin D1 -0.0234204
KDM5B lysine (K)-specific demethylase 5B -0.0231014
RPL8 ribosomal protein L8 -0.0227449
C15ORF48 chromosome 15 open reading frame 48 -0.0225783
S100A6 S100 calcium binding protein A6 -0.0224254
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0224245
RPL37A ribosomal protein L37a -0.0221173
HMGA1 high mobility group AT-hook 1 -0.0220676
GNAS GNAS complex locus -0.0220389
AGR2 anterior gradient 2 -0.0218985
HLA-B major histocompatibility complex, class I, B -0.0218711
WSB1 WD repeat and SOCS box containing 1 -0.0218565
IFI6 interferon, alpha-inducible protein 6 -0.0215677
KMT2A lysine (K)-specific methyltransferase 2A -0.0213883
RPS19 ribosomal protein S19 -0.0212305
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0211615
CUX1 cut-like homeobox 1 -0.0209976
RPL36 ribosomal protein L36 -0.0209858
RPS21 ribosomal protein S21 -0.0209755
LRP1B low density lipoprotein receptor-related protein 1B -0.0206652
S100A9 S100 calcium binding protein A9 -0.0206287
RPS17 ribosomal protein S17 -0.0206065
ANKRD37 ankyrin repeat domain 37 -0.0204734
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0204167
RPS27 ribosomal protein S27 -0.0203445
PTPRJ protein tyrosine phosphatase, receptor type, J -0.020333
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0202568
EGR1 early growth response 1 -0.020123
EIF1 eukaryotic translation initiation factor 1 -0.019946
BZW1 basic leucine zipper and W2 domains 1 -0.019878
RPS13 ribosomal protein S13 -0.0196596
B2M beta-2-microglobulin -0.0195687