c-Kit-IN-1_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.121745
SMAD3 SMAD family member 3 0.102765
SOD2 superoxide dismutase 2, mitochondrial 0.0831709
TXNRD1 thioredoxin reductase 1 0.0772317
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0762955
CD44 CD44 molecule (Indian blood group) 0.0704622
PCBP2 poly(rC) binding protein 2 0.0637517
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0631665
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0557398
ATP13A3 ATPase type 13A3 0.0521485
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.051523
PALM2AKAP2 PALM2 and AKAP2 fusion 0.051327
DDIT4 DNA-damage-inducible transcript 4 0.0497591
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0495967
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0488434
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0484555
MYH9 myosin, heavy chain 9, non-muscle 0.0483714
TGM2 transglutaminase 2 0.0456428
BHLHE40 basic helix-loop-helix family, member e40 0.0446885
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0410063
HSPA8 heat shock 70kDa protein 8 0.0393209
NAV2 neuron navigator 2 0.0384459
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0383122
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0356575
EREG epiregulin 0.0343152
FNDC3B fibronectin type III domain containing 3B 0.0340241
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0335651
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0319659
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0318386
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0312217
TFRC transferrin receptor 0.0311215
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0299199
KIF5B kinesin family member 5B 0.0296465
BIRC3 baculoviral IAP repeat containing 3 0.0286746
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0286185
PRRC2C proline-rich coiled-coil 2C 0.0284766
PNN pinin, desmosome associated protein 0.027558
SIK3 SIK family kinase 3 0.0272074
MAT2A methionine adenosyltransferase II, alpha 0.0270406
ALCAM activated leukocyte cell adhesion molecule 0.027021
XPO1 exportin 1 0.026621
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0263823
LIF leukemia inhibitory factor 0.0262972
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0255535
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0254869
SFPQ splicing factor proline/glutamine-rich 0.0249223
ADM adrenomedullin 0.0247827
ACTN4 actinin, alpha 4 0.0242817
CORO1C coronin, actin binding protein, 1C 0.0242318
MYO10 myosin X 0.0242294
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0237796
VEGFA vascular endothelial growth factor A 0.0233363
CXCL3 chemokine (C-X-C motif) ligand 3 0.0233345
CXCL5 chemokine (C-X-C motif) ligand 5 0.0232551
CHD1 chromodomain helicase DNA binding protein 1 0.0228051
NTN4 netrin 4 0.0223101
RAB27B RAB27B, member RAS oncogene family 0.0222491
EEF2 eukaryotic translation elongation factor 2 0.0222254
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0221371
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0218783
CCT2 chaperonin containing TCP1, subunit 2 (beta) 0.0213004
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0212936
SPRED2 sprouty-related, EVH1 domain containing 2 0.0212632
HOOK2 hook microtubule-tethering protein 2 0.0211713
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0211044
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0210469
UBA6 ubiquitin-like modifier activating enzyme 6 0.0210143
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0208332
GPHN gephyrin 0.0208244
TOP1 topoisomerase (DNA) I 0.0208088
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0206123
FLNB filamin B, beta 0.0205817
AMPD3 adenosine monophosphate deaminase 3 0.02049
DOCK4 dedicator of cytokinesis 4 0.0204604
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0203673
RNF24 ring finger protein 24 0.0203626
TNPO1 transportin 1 0.0203507
STRN3 striatin, calmodulin binding protein 3 0.0203217
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0202106
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0201065
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.0200767
CHD7 chromodomain helicase DNA binding protein 7 0.0200526
SET SET nuclear proto-oncogene 0.0199332
EZR ezrin 0.0198882
KSR1 kinase suppressor of ras 1 0.0198681
WDR43 WD repeat domain 43 0.019819
VRK2 vaccinia related kinase 2 0.0196082
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.019466
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0194643
MCL1 myeloid cell leukemia 1 0.0192457
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0190917
ZEB1 zinc finger E-box binding homeobox 1 0.0190844
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0190261
ZNF638 zinc finger protein 638 0.019019
QKI QKI, KH domain containing, RNA binding 0.0190162
RBM25 RNA binding motif protein 25 0.0189615
GRB10 growth factor receptor-bound protein 10 0.0188752
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0188515
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0188335
FAR1 fatty acyl CoA reductase 1 0.0187408

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249598
VIM vimentin -0.200817
FN1 fibronectin 1 -0.169661
TMSB10 thymosin beta 10 -0.127722
AKAP12 A kinase (PRKA) anchor protein 12 -0.124855
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.12122
LOX lysyl oxidase -0.107095
FTL ferritin, light polypeptide -0.0881448
IGFBP3 insulin-like growth factor binding protein 3 -0.0860168
STC1 stanniocalcin 1 -0.0787982
RPLP1 ribosomal protein, large, P1 -0.0787592
RPS6 ribosomal protein S6 -0.0745114
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0726976
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0717566
RPS8 ribosomal protein S8 -0.071697
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0687621
GOLGA4 golgin A4 -0.0681957
RPS29 ribosomal protein S29 -0.0652081
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0638605
CDH13 cadherin 13 -0.0635136
IFI6 interferon, alpha-inducible protein 6 -0.0612486
RPS19 ribosomal protein S19 -0.0612377
RPL35A ribosomal protein L35a -0.0590413
B2M beta-2-microglobulin -0.0583149
RPL37A ribosomal protein L37a -0.057177
RPS12 ribosomal protein S12 -0.0545025
LMAN1 lectin, mannose-binding, 1 -0.0533958
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0528195
RPL31 ribosomal protein L31 -0.0526615
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0523177
MEF2A myocyte enhancer factor 2A -0.0512574
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0507774
HM13 histocompatibility (minor) 13 -0.050372
S100A6 S100 calcium binding protein A6 -0.0500392
BTG1 B-cell translocation gene 1, anti-proliferative -0.0491684
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0471561
RPL34 ribosomal protein L34 -0.0462599
RPS13 ribosomal protein S13 -0.0454541
TPT1 tumor protein, translationally-controlled 1 -0.0434541
ENO1 enolase 1, (alpha) -0.0425098
RPS27 ribosomal protein S27 -0.0420445
PSD3 pleckstrin and Sec7 domain containing 3 -0.0417526
RPL11 ribosomal protein L11 -0.0414435
RPL12 ribosomal protein L12 -0.0413292
RPS17 ribosomal protein S17 -0.0412752
RPLP2 ribosomal protein, large, P2 -0.0409959
TAS2R14 taste receptor, type 2, member 14 -0.0407109
CANX calnexin -0.0397748
RPS23 ribosomal protein S23 -0.0388412
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0388318
OXR1 oxidation resistance 1 -0.0387497
RPS3 ribosomal protein S3 -0.0387338
RPL19 ribosomal protein L19 -0.0380944
RPS25 ribosomal protein S25 -0.0380569
CDCP1 CUB domain containing protein 1 -0.0378073
HLA-B major histocompatibility complex, class I, B -0.0372085
RPL36 ribosomal protein L36 -0.0371821
MTSS1 metastasis suppressor 1 -0.0367568
S100A9 S100 calcium binding protein A9 -0.0359897
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0357815
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0357
RPL28 ribosomal protein L28 -0.0348434
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0348006
PLIN2 perilipin 2 -0.0345367
EIF1 eukaryotic translation initiation factor 1 -0.034229
HMGA2 high mobility group AT-hook 2 -0.0337238
TTC3 tetratricopeptide repeat domain 3 -0.0334911
RACK1 receptor for activated C kinase 1 -0.0332404
RPL37 ribosomal protein L37 -0.0319069
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0316791
RAI14 retinoic acid induced 14 -0.031645
RPL38 ribosomal protein L38 -0.0315683
RPLP0 ribosomal protein, large, P0 -0.0315618
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0314523
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.03139
RPS14 ribosomal protein S14 -0.030868
RPS16 ribosomal protein S16 -0.0301926
IFITM3 interferon induced transmembrane protein 3 -0.0299889
ARL4C ADP-ribosylation factor-like 4C -0.0299778
TFPI2 tissue factor pathway inhibitor 2 -0.0298837
WASF2 WAS protein family, member 2 -0.0294285
RAB1A RAB1A, member RAS oncogene family -0.0293265
CUX1 cut-like homeobox 1 -0.0290804
RPS11 ribosomal protein S11 -0.0289513
S100A10 S100 calcium binding protein A10 -0.0289135
RPL13A ribosomal protein L13a -0.0287205
NDRG1 N-myc downstream regulated 1 -0.0286576
LGALS1 lectin, galactoside-binding, soluble, 1 -0.028631
ZMYND8 zinc finger, MYND-type containing 8 -0.0282051
SQSTM1 sequestosome 1 -0.0281248
RPL23 ribosomal protein L23 -0.0274938
CA12 carbonic anhydrase XII -0.0273548
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0272744
SP100 SP100 nuclear antigen -0.0270007
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0267829
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0266734
PRH1 proline-rich protein HaeIII subfamily 1 -0.0266134
SYT1 synaptotagmin I -0.0264126
DLG1 discs, large homolog 1 (Drosophila) -0.0263235
RPL32 ribosomal protein L32 -0.0262183