c-Kit-IN-1_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.206545
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.172237
ZFAND3 zinc finger, AN1-type domain 3 0.0917046
PDE4D phosphodiesterase 4D, cAMP-specific 0.0760935
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0689664
COG5 component of oligomeric golgi complex 5 0.066524
SAMD4A sterile alpha motif domain containing 4A 0.0655362
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0628922
DST dystonin 0.0572063
PM20D1 peptidase M20 domain containing 1 0.050016
SPAG9 sperm associated antigen 9 0.0487519
PRRC2C proline-rich coiled-coil 2C 0.0476405
PFDN2 prefoldin subunit 2 0.0471689
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0470195
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0456389
WWOX WW domain containing oxidoreductase 0.0449227
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0431172
GOLGA4 golgin A4 0.0418258
PTK2 protein tyrosine kinase 2 0.0414468
WDR43 WD repeat domain 43 0.0414453
GARS1 glycyl-tRNA synthetase 1 0.0410603
USP34 ubiquitin specific peptidase 34 0.040502
CXCL8 chemokine (C-X-C motif) ligand 8 0.0404883
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0402744
NBAS neuroblastoma amplified sequence 0.0401729
FNDC3B fibronectin type III domain containing 3B 0.0399717
TNPO1 transportin 1 0.0393457
OLA1 Obg-like ATPase 1 0.0392715
ANKRD11 ankyrin repeat domain 11 0.0383883
BIRC3 baculoviral IAP repeat containing 3 0.0377822
ZEB1 zinc finger E-box binding homeobox 1 0.0365469
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.03632
NCKAP1 NCK-associated protein 1 0.0354103
NUP58 nucleoporin 58 0.035324
MEMO1 mediator of cell motility 1 0.0346535
GPHN gephyrin 0.0345188
ADAM17 ADAM metallopeptidase domain 17 0.0342956
NAV3 neuron navigator 3 0.0338625
CHD1 chromodomain helicase DNA binding protein 1 0.0338019
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0337087
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0330819
NHSL1 NHS-like 1 0.0328558
ANK2 ankyrin 2, neuronal 0.0321116
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0317603
BRD2 bromodomain containing 2 0.0313046
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0309494
RPTOR regulatory associated protein of MTOR, complex 1 0.0304496
MAP1B microtubule-associated protein 1B 0.0303038
GLS2 glutaminase 2 (liver, mitochondrial) 0.0297738
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0297452
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0297346
TFPI2 tissue factor pathway inhibitor 2 0.0297261
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0297202
TARS1 threonyl-tRNA synthetase 1 0.0292859
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0290985
RPS19 ribosomal protein S19 0.0289808
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0289149
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0288373
RAB6A RAB6A, member RAS oncogene family 0.0287764
TRAF3 TNF receptor-associated factor 3 0.0286597
KPNB1 karyopherin (importin) beta 1 0.0284234
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0283639
CREB5 cAMP responsive element binding protein 5 0.0282155
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0281124
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0280507
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0279815
SFPQ splicing factor proline/glutamine-rich 0.0279455
NPTN neuroplastin 0.0278948
ATP11A ATPase, class VI, type 11A 0.0276785
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0274386
PRKCE protein kinase C, epsilon 0.0273505
NAMPT nicotinamide phosphoribosyltransferase 0.0268212
FNIP1 folliculin interacting protein 1 0.0267408
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 0.0266151
CDC73 cell division cycle 73 0.0264212
PUM2 pumilio RNA-binding family member 2 0.0262359
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0261392
RLF rearranged L-myc fusion 0.0258259
TFRC transferrin receptor 0.0256496
ATP13A3 ATPase type 13A3 0.0254023
TSC22D2 TSC22 domain family, member 2 0.0251706
STK4 serine/threonine kinase 4 0.0251627
MARCHF6 membrane associated ring-CH-type finger 6 0.0250527
CFLAR CASP8 and FADD-like apoptosis regulator 0.0249264
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247511
SND1 staphylococcal nuclease and tudor domain containing 1 0.0247303
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0246745
GPATCH2L G patch domain containing 2-like 0.0245018
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0243472
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0240962
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0240784
ASPH aspartate beta-hydroxylase 0.0237404
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0236181
USP36 ubiquitin specific peptidase 36 0.0235922
PCNX1 pecanex 1 0.0235679
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0235566
PTPRM protein tyrosine phosphatase, receptor type, M 0.0234801
SOD2 superoxide dismutase 2, mitochondrial 0.0234656
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0234278
MCL1 myeloid cell leukemia 1 0.0233388

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.173018
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16741
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.127965
SLC38A2 solute carrier family 38, member 2 -0.105527
IGF2 insulin-like growth factor 2 -0.104484
ERBIN erbb2 interacting protein -0.0987017
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0898654
HDAC9 histone deacetylase 9 -0.0755441
PKM pyruvate kinase, muscle -0.0700644
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.069794
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0692217
POTEF POTE ankyrin domain family, member F -0.0683224
TXNRD1 thioredoxin reductase 1 -0.0666547
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0647478
UBASH3B ubiquitin associated and SH3 domain containing B -0.0630566
S100A6 S100 calcium binding protein A6 -0.0617646
UTRN utrophin -0.0600643
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0585685
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0565951
FGB fibrinogen beta chain -0.0557288
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0551462
PTMA prothymosin, alpha -0.0548725
TNRC6B trinucleotide repeat containing 6B -0.0534011
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0491061
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0485179
MAML3 mastermind-like 3 (Drosophila) -0.0482031
TMSB10 thymosin beta 10 -0.048125
ACTG1 actin gamma 1 -0.0454881
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.045022
LDHA lactate dehydrogenase A -0.0449755
BICC1 BicC family RNA binding protein 1 -0.0448508
NEGR1 neuronal growth regulator 1 -0.0439949
PRR16 proline rich 16 -0.0436024
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0435841
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0407339
RHOA ras homolog family member A -0.0401175
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0400326
TPM4 tropomyosin 4 -0.0393646
AHR aryl hydrocarbon receptor -0.0382866
CHN1 chimerin 1 -0.0382147
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0380622
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0377649
DOCK4 dedicator of cytokinesis 4 -0.0374113
MYOF myoferlin -0.0365802
BASP1 brain abundant, membrane attached signal protein 1 -0.0359018
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0358487
PLS3 plastin 3 -0.0356394
RPL19 ribosomal protein L19 -0.0350046
SVIL supervillin -0.0349885
PARD3 par-3 family cell polarity regulator -0.0348169
EFNA5 ephrin-A5 -0.0347828
KYNU kynureninase -0.034637
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0343712
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0343089
MBNL1 muscleblind-like splicing regulator 1 -0.0342231
EEF2 eukaryotic translation elongation factor 2 -0.0338205
TAGLN2 transgelin 2 -0.033535
IGFBP4 insulin-like growth factor binding protein 4 -0.0327429
FAM107B family with sequence similarity 107, member B -0.0326041
FTH1 ferritin, heavy polypeptide 1 -0.0324816
IST1 increased sodium tolerance 1 homolog (yeast) -0.032434
APP amyloid beta (A4) precursor protein -0.0322258
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0321117
ARHGAP29 Rho GTPase activating protein 29 -0.0320924
PAWR PRKC, apoptosis, WT1, regulator -0.0309553
FBXL20 F-box and leucine-rich repeat protein 20 -0.0307697
BHLHE40 basic helix-loop-helix family, member e40 -0.0305335
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0301827
RPS6 ribosomal protein S6 -0.0300938
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298536
RPL13A ribosomal protein L13a -0.0298496
NTN4 netrin 4 -0.0295309
RPS8 ribosomal protein S8 -0.0293732
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0292607
PYGL phosphorylase, glycogen, liver -0.029182
KDM5B lysine (K)-specific demethylase 5B -0.0289485
KAT6B K(lysine) acetyltransferase 6B -0.0288737
YBX1 Y box binding protein 1 -0.0288375
HMGA1 high mobility group AT-hook 1 -0.0287013
THSD4 thrombospondin, type I, domain containing 4 -0.0283812
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0283
DOCK5 dedicator of cytokinesis 5 -0.0280761
HBP1 HMG-box transcription factor 1 -0.0278707
SRGN serglycin -0.027704
CCN2 cellular communication network factor 2 -0.0276488
TMEM123 transmembrane protein 123 -0.0273293
MORF4L1 mortality factor 4 like 1 -0.0270778
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0270416
IGFBP3 insulin-like growth factor binding protein 3 -0.0269376
OSBPL9 oxysterol binding protein-like 9 -0.0267351
ECT2 epithelial cell transforming 2 -0.0260558
NEBL nebulette -0.025766
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0257507
RPL8 ribosomal protein L8 -0.0255433
MITF microphthalmia-associated transcription factor -0.025518
NCEH1 neutral cholesterol ester hydrolase 1 -0.0253567
RPS27A ribosomal protein S27a -0.0252998
DENND5B DENN/MADD domain containing 5B -0.02522
AKAP13 A kinase (PRKA) anchor protein 13 -0.0250723
CAVIN1 caveolae associated protein 1 -0.0249515