c-Kit-IN-1_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.124287
LRPPRC leucine-rich pentatricopeptide repeat containing 0.122756
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114849
GPHN gephyrin 0.0982988
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0971361
PDE4D phosphodiesterase 4D, cAMP-specific 0.0885122
ZFAND3 zinc finger, AN1-type domain 3 0.0881628
TPM3 tropomyosin 3 0.0832403
HSPA8 heat shock 70kDa protein 8 0.079796
AKAP12 A kinase (PRKA) anchor protein 12 0.0797687
GRAMD1B GRAM domain containing 1B 0.0750898
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0737659
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0736879
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0717352
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0656967
RAD51B RAD51 paralog B 0.0652341
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0649922
SND1 staphylococcal nuclease and tudor domain containing 1 0.0649309
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0638615
ZCCHC7 zinc finger, CCHC domain containing 7 0.0613921
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0610075
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0609316
MACF1 microtubule-actin crosslinking factor 1 0.0607217
SFPQ splicing factor proline/glutamine-rich 0.0601841
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0589365
DST dystonin 0.0581484
AFF3 AF4/FMR2 family, member 3 0.0580792
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0573693
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0573049
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0571347
CAMKMT calmodulin-lysine N-methyltransferase 0.0568684
PRKCE protein kinase C, epsilon 0.0565104
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0561876
PTK2 protein tyrosine kinase 2 0.0550226
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0547409
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0538147
SAMD4A sterile alpha motif domain containing 4A 0.0537039
FKBP4 FK506 binding protein 4, 59kDa 0.0529539
IPO7 importin 7 0.0500075
WWOX WW domain containing oxidoreductase 0.0496744
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0495196
FAF1 Fas (TNFRSF6) associated factor 1 0.0492955
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0492039
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0490623
XPOT exportin, tRNA 0.049025
TAS2R14 taste receptor, type 2, member 14 0.0483278
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0477788
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0474056
PCBP2 poly(rC) binding protein 2 0.0469418
ZNF638 zinc finger protein 638 0.0465149
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0464315
FMNL2 formin-like 2 0.046128
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 0.0457682
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0454864
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0450936
CSDE1 cold shock domain containing E1, RNA-binding 0.0448988
GMDS GDP-mannose 4,6-dehydratase 0.0448716
CCND2 cyclin D2 0.0436281
TRIO trio Rho guanine nucleotide exchange factor 0.0435529
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0428378
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0414655
CTTN cortactin 0.0413205
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.041236
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0410281
RAB7A RAB7A, member RAS oncogene family 0.040851
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 0.0408061
ANKRD17 ankyrin repeat domain 17 0.0403817
MYH9 myosin, heavy chain 9, non-muscle 0.0402431
SRRM2 serine/arginine repetitive matrix 2 0.0401196
NF1 neurofibromin 1 0.0389029
WNK1 WNK lysine deficient protein kinase 1 0.0387184
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0385925
DIDO1 death inducer-obliterator 1 0.0384819
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0384251
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0381162
KDM2A lysine (K)-specific demethylase 2A 0.0380752
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0379393
ANK2 ankyrin 2, neuronal 0.037698
ADAR adenosine deaminase, RNA-specific 0.0371212
ANKRD11 ankyrin repeat domain 11 0.0365988
WDR43 WD repeat domain 43 0.0365116
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0361334
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0359755
SERBP1 SERPINE1 mRNA binding protein 1 0.0357026
DENND1A DENN/MADD domain containing 1A 0.0354892
TRIP12 thyroid hormone receptor interactor 12 0.0350931
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0350615
CLTC clathrin, heavy chain (Hc) 0.03498
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0349575
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0344942
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0340985
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0338834
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0338503
CAMTA1 calmodulin binding transcription activator 1 0.0336784
EML4 echinoderm microtubule associated protein like 4 0.0332588
ZSWIM6 zinc finger, SWIM-type containing 6 0.0331
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0330605
PLEC plectin 0.0328587
USP34 ubiquitin specific peptidase 34 0.0328349
MSH6 mutS homolog 6 0.0328037

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.217213
YBX3 Y box binding protein 3 -0.0614892
TMSB10 thymosin beta 10 -0.0550318
RPS21 ribosomal protein S21 -0.0475555
RPS3 ribosomal protein S3 -0.0469678
RPS29 ribosomal protein S29 -0.0457766
RPL12 ribosomal protein L12 -0.0438522
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0437955
RPL26 ribosomal protein L26 -0.0419489
RPS27 ribosomal protein S27 -0.0415826
MYL12B myosin, light chain 12B, regulatory -0.0389755
RPLP1 ribosomal protein, large, P1 -0.037048
RPLP2 ribosomal protein, large, P2 -0.0368323
MT2A metallothionein 2A -0.0366125
RPL37A ribosomal protein L37a -0.0350397
RPS27A ribosomal protein S27a -0.0339819
ZBTB20 zinc finger and BTB domain containing 20 -0.0338369
RPL35A ribosomal protein L35a -0.0338075
NABP1 nucleic acid binding protein 1 -0.0331254
EGR1 early growth response 1 -0.0330922
ACTG1 actin gamma 1 -0.0321036
TXNRD1 thioredoxin reductase 1 -0.0304854
RPS15 ribosomal protein S15 -0.0303462
RPS8 ribosomal protein S8 -0.02944
TPT1 tumor protein, translationally-controlled 1 -0.0293597
RPS19 ribosomal protein S19 -0.0286216
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0278682
FTL ferritin, light polypeptide -0.0265891
SLC38A2 solute carrier family 38, member 2 -0.0259582
WSB1 WD repeat and SOCS box containing 1 -0.0254212
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0249877
RPL11 ribosomal protein L11 -0.0249336
OSMR oncostatin M receptor -0.0246898
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0243397
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0242113
RPL28 ribosomal protein L28 -0.0237385
RPL31 ribosomal protein L31 -0.0237312
RPL35 ribosomal protein L35 -0.0237289
HBP1 HMG-box transcription factor 1 -0.023436
RPL36 ribosomal protein L36 -0.0229753
SMC4 structural maintenance of chromosomes 4 -0.0228056
RSF1 remodeling and spacing factor 1 -0.0221194
RPL13A ribosomal protein L13a -0.022016
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0219444
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0216687
RPL27 ribosomal protein L27 -0.0214444
RPS23 ribosomal protein S23 -0.0213512
PFN1 profilin 1 -0.0213239
CALD1 caldesmon 1 -0.0212839
GATAD2B GATA zinc finger domain containing 2B -0.0212542
TM4SF1 transmembrane 4 L six family member 1 -0.0212234
RPLP0 ribosomal protein, large, P0 -0.0211688
LIMA1 LIM domain and actin binding 1 -0.020684
RB1CC1 RB1-inducible coiled-coil 1 -0.0206834
MYPN myopalladin -0.0204648
RPL38 ribosomal protein L38 -0.020212
MIS18BP1 MIS18 binding protein 1 -0.0198246
RPS6 ribosomal protein S6 -0.0198195
B2M beta-2-microglobulin -0.0196862
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0194008
CCDC91 coiled-coil domain containing 91 -0.0192889
IFI6 interferon, alpha-inducible protein 6 -0.0189178
IGF2 insulin-like growth factor 2 -0.0186741
RPL9 ribosomal protein L9 -0.0186445
CHIC2 cysteine-rich hydrophobic domain 2 -0.0186152
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0184935
RPL37 ribosomal protein L37 -0.0181052
SBF2 SET binding factor 2 -0.0180898
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0180791
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0180248
RPL19 ribosomal protein L19 -0.0178004
KLF6 Kruppel-like factor 6 -0.0176924
RPS10 ribosomal protein S10 -0.0176259
SEPTIN7 septin 7 -0.0169182
WASF2 WAS protein family, member 2 -0.0168179
RPL36A ribosomal protein L36a -0.0167726
WWTR1 WW domain containing transcription regulator 1 -0.0164176
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0160116
RPS17 ribosomal protein S17 -0.0159356
TBC1D15 TBC1 domain family, member 15 -0.01593
POTEF POTE ankyrin domain family, member F -0.0159111
BCAS3 breast carcinoma amplified sequence 3 -0.0158142
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0155963
RPL5 ribosomal protein L5 -0.0155052
RPS2 ribosomal protein S2 -0.0152592
RPS14 ribosomal protein S14 -0.0152435
RPS13 ribosomal protein S13 -0.015143
RPL34 ribosomal protein L34 -0.0148097
RPS12 ribosomal protein S12 -0.0147383
RPS5 ribosomal protein S5 -0.0146887
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0146816
RPS11 ribosomal protein S11 -0.0146706
RPS25 ribosomal protein S25 -0.0144774
CTTNBP2NL CTTNBP2 N-terminal like -0.0144769
PTMA prothymosin, alpha -0.014304
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.0143019
TCEAL4 transcription elongation factor A (SII)-like 4 -0.014278
FBXL20 F-box and leucine-rich repeat protein 20 -0.0142457
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -0.0141718
RPL27A ribosomal protein L27a -0.014127