c-Kit-IN-1_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.183966
NDRG1 N-myc downstream regulated 1 0.129945
DTNA dystrobrevin, alpha 0.123421
FNDC3B fibronectin type III domain containing 3B 0.106476
FHIT fragile histidine triad 0.0998886
NAMPT nicotinamide phosphoribosyltransferase 0.0942134
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0892811
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0870007
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0734495
TXNRD1 thioredoxin reductase 1 0.0733913
PTK2 protein tyrosine kinase 2 0.0711387
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0670598
ASPH aspartate beta-hydroxylase 0.0666695
GOLGA4 golgin A4 0.0658507
UBA6 ubiquitin-like modifier activating enzyme 6 0.0655084
TSC22D2 TSC22 domain family, member 2 0.0625325
ZFAND3 zinc finger, AN1-type domain 3 0.0608027
GLS2 glutaminase 2 (liver, mitochondrial) 0.0593274
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0563951
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0546868
GARS1 glycyl-tRNA synthetase 1 0.0540772
CHD1 chromodomain helicase DNA binding protein 1 0.0526054
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0521176
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0513752
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0507063
DLG1 discs, large homolog 1 (Drosophila) 0.050187
PRRC2C proline-rich coiled-coil 2C 0.0499975
CCNL1 cyclin L1 0.0499547
MYH9 myosin, heavy chain 9, non-muscle 0.0491584
LDHA lactate dehydrogenase A 0.0488452
RNF145 ring finger protein 145 0.0468916
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0463255
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0462922
ELL2 elongation factor, RNA polymerase II, 2 0.0459029
GPHN gephyrin 0.0455801
TFRC transferrin receptor 0.0450786
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0449304
BHLHE40 basic helix-loop-helix family, member e40 0.0447352
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0438934
ADAM9 ADAM metallopeptidase domain 9 0.0423875
RLF rearranged L-myc fusion 0.0421467
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0417366
MATR3 matrin 3 0.0413396
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0402462
ATP13A3 ATPase type 13A3 0.0401595
TPD52 tumor protein D52 0.0401481
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.039858
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0397948
RBM25 RNA binding motif protein 25 0.0395045
EEF2 eukaryotic translation elongation factor 2 0.0392745
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0391
PCBP2 poly(rC) binding protein 2 0.0390616
RUNX1 runt-related transcription factor 1 0.0383753
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0381365
NUP58 nucleoporin 58 0.0377005
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376217
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0375725
TARS1 threonyl-tRNA synthetase 1 0.0375637
USP9X ubiquitin specific peptidase 9, X-linked 0.0369683
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0368464
PGK1 phosphoglycerate kinase 1 0.036591
KMT2E lysine (K)-specific methyltransferase 2E 0.0365467
CLINT1 clathrin interactor 1 0.0365006
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0359975
TFG TRK-fused gene 0.0357293
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0354753
APP amyloid beta (A4) precursor protein 0.0353713
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.035348
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0352335
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0351938
GSK3B glycogen synthase kinase 3 beta 0.0347462
SLMAP sarcolemma associated protein 0.0344924
NCKAP1 NCK-associated protein 1 0.0344799
CLTC clathrin, heavy chain (Hc) 0.0341471
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0340581
RYBP RING1 and YY1 binding protein 0.0337171
SMYD3 SET and MYND domain containing 3 0.0337119
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.033704
NPTN neuroplastin 0.0333633
PUM1 pumilio RNA-binding family member 1 0.0327202
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0323938
WDR43 WD repeat domain 43 0.0323315
SPAG9 sperm associated antigen 9 0.0321312
PDIA6 protein disulfide isomerase family A, member 6 0.032113
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0319943
WAC WW domain containing adaptor with coiled-coil 0.0318208
HSPA8 heat shock 70kDa protein 8 0.031794
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0315425
SEC23A Sec23 homolog A (S. cerevisiae) 0.0315094
NGLY1 N-glycanase 1 0.0314074
XPO1 exportin 1 0.0313151
CDC73 cell division cycle 73 0.0312775
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0308728
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0300649
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit 0.0300548
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0297752
ARRDC3 arrestin domain containing 3 0.0296953
IL6ST interleukin 6 signal transducer 0.0292739
ZNF207 zinc finger protein 207 0.0288877
PPARD peroxisome proliferator-activated receptor delta 0.0288565

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.160163
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143308
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0991469
PTMA prothymosin, alpha -0.0990772
TPT1 tumor protein, translationally-controlled 1 -0.0808571
LMO7 LIM domain 7 -0.0775528
FBXO32 F-box protein 32 -0.0749116
TMSB10 thymosin beta 10 -0.0664308
FTL ferritin, light polypeptide -0.0650559
RPS8 ribosomal protein S8 -0.0635839
TM4SF1 transmembrane 4 L six family member 1 -0.0604406
LIMCH1 LIM and calponin homology domains 1 -0.0547953
RPS29 ribosomal protein S29 -0.053797
CCND1 cyclin D1 -0.0521318
RPS3 ribosomal protein S3 -0.0511598
RPL34 ribosomal protein L34 -0.0501687
SAMD4A sterile alpha motif domain containing 4A -0.0498606
RPS23 ribosomal protein S23 -0.0482433
RPS13 ribosomal protein S13 -0.0480239
RPLP1 ribosomal protein, large, P1 -0.0462651
IGFBP3 insulin-like growth factor binding protein 3 -0.0462572
FTH1 ferritin, heavy polypeptide 1 -0.0454815
EIF1 eukaryotic translation initiation factor 1 -0.0452388
RPS6 ribosomal protein S6 -0.0447515
LPP LIM domain containing preferred translocation partner in lipoma -0.0440381
RPL35A ribosomal protein L35a -0.0436745
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0435035
HLA-B major histocompatibility complex, class I, B -0.0423103
TPM4 tropomyosin 4 -0.0400278
VCL vinculin -0.0399799
IFI6 interferon, alpha-inducible protein 6 -0.0381676
RPLP2 ribosomal protein, large, P2 -0.0381443
RPL9 ribosomal protein L9 -0.0380578
BZW1 basic leucine zipper and W2 domains 1 -0.0379807
RPS27A ribosomal protein S27a -0.0378915
GNAS GNAS complex locus -0.0377023
FN1 fibronectin 1 -0.0376501
S100A10 S100 calcium binding protein A10 -0.0367801
RPL31 ribosomal protein L31 -0.0366302
PDLIM5 PDZ and LIM domain 5 -0.0365346
EXT1 exostosin glycosyltransferase 1 -0.0364081
MYO6 myosin VI -0.0361321
SOX4 SRY (sex determining region Y)-box 4 -0.0359445
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0359177
RPL11 ribosomal protein L11 -0.0357591
SQSTM1 sequestosome 1 -0.0357229
ISG15 ISG15 ubiquitin-like modifier -0.0356063
EFNA5 ephrin-A5 -0.0345764
IFI16 interferon, gamma-inducible protein 16 -0.0345581
RPL19 ribosomal protein L19 -0.0343526
ALCAM activated leukocyte cell adhesion molecule -0.0342061
VIM vimentin -0.0341198
AHNAK AHNAK nucleoprotein -0.0339853
TMSB4X thymosin beta 4, X-linked -0.0338468
S100A6 S100 calcium binding protein A6 -0.0332688
RPL37A ribosomal protein L37a -0.0325343
RPS25 ribosomal protein S25 -0.0322923
RPS17 ribosomal protein S17 -0.0322151
RPS12 ribosomal protein S12 -0.0318975
MYO1E myosin IE -0.0316088
SP100 SP100 nuclear antigen -0.0311784
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0307212
RPL8 ribosomal protein L8 -0.0305309
FBXO34 F-box protein 34 -0.0301712
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0299289
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.029448
KRT7 keratin 7, type II -0.0293179
WSB1 WD repeat and SOCS box containing 1 -0.0292275
ZC3H3 zinc finger CCCH-type containing 3 -0.0289058
RPL23 ribosomal protein L23 -0.0288394
RACK1 receptor for activated C kinase 1 -0.0286679
RPL12 ribosomal protein L12 -0.0285828
BASP1 brain abundant, membrane attached signal protein 1 -0.0285577
HLA-A major histocompatibility complex, class I, A -0.0285209
INTS6 integrator complex subunit 6 -0.0283174
RPS10 ribosomal protein S10 -0.0281704
CSTB cystatin B (stefin B) -0.0279806
ARHGAP20 Rho GTPase activating protein 20 -0.0276909
IFI27 interferon, alpha-inducible protein 27 -0.027518
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0273658
POTEF POTE ankyrin domain family, member F -0.0272501
RPLP0 ribosomal protein, large, P0 -0.0272235
KLHL24 kelch-like family member 24 -0.0268295
AHNAK2 AHNAK nucleoprotein 2 -0.0261118
RPS15 ribosomal protein S15 -0.0258584
GOLGB1 golgin B1 -0.0257011
KRT18 keratin 18, type I -0.0251658
ATOSA atos homolog A -0.0247197
LAMC2 laminin, gamma 2 -0.0245973
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0242881
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0242261
FBXL20 F-box and leucine-rich repeat protein 20 -0.0241817
SACK1A scaffolding CK1 anchoring protein A -0.0241312
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0240642
TBCA tubulin folding cofactor A -0.0236069
CAVIN1 caveolae associated protein 1 -0.0235957
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0233744
IFITM3 interferon induced transmembrane protein 3 -0.0233689
RPS27 ribosomal protein S27 -0.0231097
RIGI RNA sensor RIG-I -0.0231063