c-Kit-IN-1_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PARD3 par-3 family cell polarity regulator 0.114528
MYO5B myosin VB 0.109629
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.109142
BAIAP2L1 BAI1-associated protein 2-like 1 0.108064
CHRM3 cholinergic receptor, muscarinic 3 0.104589
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.102073
ENAH enabled homolog (Drosophila) 0.101045
ACTN4 actinin, alpha 4 0.0973873
TSC22D2 TSC22 domain family, member 2 0.0972122
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0936
CCNL1 cyclin L1 0.0893094
STRN3 striatin, calmodulin binding protein 3 0.0886972
MRPS6 mitochondrial ribosomal protein S6 0.088446
MED13 mediator complex subunit 13 0.0881888
OSBPL8 oxysterol binding protein-like 8 0.0871925
ZNF638 zinc finger protein 638 0.0830235
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0808813
HSPH1 heat shock 105kDa/110kDa protein 1 0.0808633
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0796585
NAP1L1 nucleosome assembly protein 1-like 1 0.0792705
ZFAND3 zinc finger, AN1-type domain 3 0.076667
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0752584
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0746784
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.07338
VEZT vezatin, adherens junctions transmembrane protein 0.0712501
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0692278
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0688939
STAU1 staufen double-stranded RNA binding protein 1 0.068562
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0684298
INTS6 integrator complex subunit 6 0.0674992
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0673786
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0669438
HSPA8 heat shock 70kDa protein 8 0.0668889
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0664402
SMAD3 SMAD family member 3 0.0622523
CTNND1 catenin (cadherin-associated protein), delta 1 0.0620111
ARHGAP5 Rho GTPase activating protein 5 0.0613972
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0581574
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0577775
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0577232
JMJD1C jumonji domain containing 1C 0.0572466
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0571653
ANKRD11 ankyrin repeat domain 11 0.0563449
SYT1 synaptotagmin I 0.0562201
HDLBP high density lipoprotein binding protein 0.0487206
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0464009
BIRC6 baculoviral IAP repeat containing 6 0.0460041
ZSWIM6 zinc finger, SWIM-type containing 6 0.0445339
IGF2 insulin-like growth factor 2 0.0431573
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0429962
TBC1D22A TBC1 domain family, member 22A 0.0425058
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0420824
TXNRD1 thioredoxin reductase 1 0.0399019
IRS2 insulin receptor substrate 2 0.0352222
PTPRM protein tyrosine phosphatase, receptor type, M 0.0346157
TENM3 teneurin transmembrane protein 3 0.0332025
NAMPT nicotinamide phosphoribosyltransferase 0.0321317
ZNF292 zinc finger protein 292 0.0318654
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0317862
TPD52 tumor protein D52 0.0316915
GSK3B glycogen synthase kinase 3 beta 0.0315733
EZR ezrin 0.0309029
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0307541
PNN pinin, desmosome associated protein 0.0304608
ARF1 ADP-ribosylation factor 1 0.0302359
RERE arginine-glutamic acid dipeptide (RE) repeats 0.02918
FTL ferritin, light polypeptide 0.0291753
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0290685
PKM pyruvate kinase, muscle 0.0285337
LMO7 LIM domain 7 0.0281082
RABGAP1L RAB GTPase activating protein 1-like 0.0255328
MAML2 mastermind-like 2 (Drosophila) 0.0253963
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0224874
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0217356
EIF4A2 eukaryotic translation initiation factor 4A2 0.0211464
EPS8 epidermal growth factor receptor pathway substrate 8 0.0211192
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0208999
DLG1 discs, large homolog 1 (Drosophila) 0.019441
PDIA3 protein disulfide isomerase family A, member 3 0.019336
RAD51B RAD51 paralog B 0.018961
RBM39 RNA binding motif protein 39 0.0189429
NCOR1 nuclear receptor corepressor 1 0.0187417
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0173765
TTC3 tetratricopeptide repeat domain 3 0.0162094
DST dystonin 0.0161866
SND1 staphylococcal nuclease and tudor domain containing 1 0.0159036
EIF5B eukaryotic translation initiation factor 5B 0.014825
SLC38A2 solute carrier family 38, member 2 0.014419
RPL11 ribosomal protein L11 0.0137362
MACF1 microtubule-actin crosslinking factor 1 0.0133945
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0130023
NAV2 neuron navigator 2 0.0129305
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0126962
WDR43 WD repeat domain 43 0.0115048
RPLP2 ribosomal protein, large, P2 0.0108372
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0108052
RPL23 ribosomal protein L23 0.00913183
SQSTM1 sequestosome 1 0.00860502
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0082114
ALCAM activated leukocyte cell adhesion molecule 0.00810432

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.369566
VIM vimentin -0.163025
FN1 fibronectin 1 -0.149647
PTMA prothymosin, alpha -0.128358
FLNB filamin B, beta -0.12699
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.119642
ACTG1 actin gamma 1 -0.107494
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.107298
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.104065
TPT1 tumor protein, translationally-controlled 1 -0.100705
RPS8 ribosomal protein S8 -0.0969066
TMSB10 thymosin beta 10 -0.0954552
ASPH aspartate beta-hydroxylase -0.0922662
ZBTB20 zinc finger and BTB domain containing 20 -0.089772
PRKCA protein kinase C, alpha -0.0891861
TRIO trio Rho guanine nucleotide exchange factor -0.0883113
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0862491
RPS6 ribosomal protein S6 -0.0852377
IGFBP3 insulin-like growth factor binding protein 3 -0.0844704
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0813557
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0704264
CANX calnexin -0.0695996
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0647388
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0637568
PDE10A phosphodiesterase 10A -0.0628092
ENO1 enolase 1, (alpha) -0.0625619
VMP1 vacuole membrane protein 1 -0.0618416
RPL32 ribosomal protein L32 -0.0606361
PRRC2C proline-rich coiled-coil 2C -0.0597328
RPL37 ribosomal protein L37 -0.0583802
NDRG1 N-myc downstream regulated 1 -0.0583378
RPS12 ribosomal protein S12 -0.0582403
FTH1 ferritin, heavy polypeptide 1 -0.0579142
MYOF myoferlin -0.0573197
NPAS2 neuronal PAS domain protein 2 -0.0567601
RPS19 ribosomal protein S19 -0.0563676
KMT2C lysine (K)-specific methyltransferase 2C -0.0548221
FNDC3B fibronectin type III domain containing 3B -0.0537993
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0529584
EGFR epidermal growth factor receptor -0.051611
EEF2 eukaryotic translation elongation factor 2 -0.0502202
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0499803
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0499573
RPL37A ribosomal protein L37a -0.0491039
RACK1 receptor for activated C kinase 1 -0.0469502
RPLP1 ribosomal protein, large, P1 -0.0467828
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0446237
RPL34 ribosomal protein L34 -0.0442708
RPL13A ribosomal protein L13a -0.0437173
HMGA2 high mobility group AT-hook 2 -0.0432632
RPL31 ribosomal protein L31 -0.0429644
FHIT fragile histidine triad -0.040562
RPS13 ribosomal protein S13 -0.0385243
EGR1 early growth response 1 -0.0383058
ANKHD1 ankyrin repeat and KH domain containing 1 -0.037121
GOLGA4 golgin A4 -0.0366521
H3-3B H3.3 histone B -0.0365791
KRT18 keratin 18, type I -0.0362465
RPLP0 ribosomal protein, large, P0 -0.0359081
MYO1E myosin IE -0.0344503
RPL15 ribosomal protein L15 -0.0331715
EIF1 eukaryotic translation initiation factor 1 -0.032594
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0281046
RPL28 ribosomal protein L28 -0.0275726
ANXA2 annexin A2 -0.0267773
RPL35A ribosomal protein L35a -0.0263227
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0250105
LOC112694756 uncharaterized LOC112694756 -0.0235149
CBX3 chromobox homolog 3 -0.0223905
RPS17 ribosomal protein S17 -0.0209955
HELZ helicase with zinc finger -0.020915
PRELID2 PRELI domain containing 2 -0.0188037
LAMA4 laminin, alpha 4 -0.0187579
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0174334
CARD16 caspase recruitment domain family, member 16 -0.0169824
RPL7A ribosomal protein L7a -0.0160049
YAP1 Yes-associated protein 1 -0.0156701
RPL27 ribosomal protein L27 -0.0155301
LDHA lactate dehydrogenase A -0.0151514
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0147813
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.014557
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0144693
GNAS GNAS complex locus -0.0123872
RPS3 ribosomal protein S3 -0.0114961
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0113567
GOLGB1 golgin B1 -0.0108599
RPL26 ribosomal protein L26 -0.0104591
SH3KBP1 SH3-domain kinase binding protein 1 -0.0101224
SRRM2 serine/arginine repetitive matrix 2 -0.00901883
EFNA5 ephrin-A5 -0.00869804
RPS11 ribosomal protein S11 -0.00836659
RPS27A ribosomal protein S27a -0.00811889
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.00775509
RPS16 ribosomal protein S16 -0.00764098
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0067016
RPS20 ribosomal protein S20 -0.00605579
TM9SF3 transmembrane 9 superfamily member 3 -0.00577308
NKD1 naked cuticle homolog 1 (Drosophila) -0.00532477
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.00411193
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.00221087