c-Kit-IN-1_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.151109
AKAP12 A kinase (PRKA) anchor protein 12 0.149365
SLC35F3 solute carrier family 35, member F3 0.111666
DST dystonin 0.105748
THSD4 thrombospondin, type I, domain containing 4 0.0684266
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0649903
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0597611
ZFAND3 zinc finger, AN1-type domain 3 0.0597385
VCL vinculin 0.0578332
SAMD4A sterile alpha motif domain containing 4A 0.0547974
ATP13A3 ATPase type 13A3 0.0544359
MAP1B microtubule-associated protein 1B 0.0533972
SAMD4B sterile alpha motif domain containing 4B 0.0516376
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0510256
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.050181
PTK2 protein tyrosine kinase 2 0.0499227
ASPH aspartate beta-hydroxylase 0.049731
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0495574
NUP98 nucleoporin 98kDa 0.0470099
FNIP1 folliculin interacting protein 1 0.0469323
GARS1 glycyl-tRNA synthetase 1 0.0454008
FRMD5 FERM domain containing 5 0.044449
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0443944
MACF1 microtubule-actin crosslinking factor 1 0.0437954
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0427929
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0414551
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0413246
MYH9 myosin, heavy chain 9, non-muscle 0.0399416
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0395333
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0395075
BIRC6 baculoviral IAP repeat containing 6 0.0394035
ZSWIM6 zinc finger, SWIM-type containing 6 0.0392389
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0387606
COG5 component of oligomeric golgi complex 5 0.038439
FNDC3B fibronectin type III domain containing 3B 0.0381595
CMIP c-Maf inducing protein 0.0374971
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0374839
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0374003
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0368211
HSPA8 heat shock 70kDa protein 8 0.036487
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0355005
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0350295
ARHGAP32 Rho GTPase activating protein 32 0.0348702
USP34 ubiquitin specific peptidase 34 0.034745
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0345132
SIK3 SIK family kinase 3 0.0343048
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0340583
EEF2 eukaryotic translation elongation factor 2 0.0336367
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0334011
CARD18 caspase recruitment domain family, member 18 0.0331818
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.033067
EXT1 exostosin glycosyltransferase 1 0.0329141
ATXN1 ataxin 1 0.0328343
PRKCE protein kinase C, epsilon 0.0321662
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0318124
HMGA2 high mobility group AT-hook 2 0.0317435
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0312904
FAF1 Fas (TNFRSF6) associated factor 1 0.0310005
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.031
ERRFI1 ERBB receptor feedback inhibitor 1 0.0306074
WDR43 WD repeat domain 43 0.0304923
NPAS2 neuronal PAS domain protein 2 0.030459
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0304088
JMJD1C jumonji domain containing 1C 0.0303885
INTS6 integrator complex subunit 6 0.0301767
TRIP12 thyroid hormone receptor interactor 12 0.0301159
NF1 neurofibromin 1 0.0300418
TRIO trio Rho guanine nucleotide exchange factor 0.0296455
EHBP1 EH domain binding protein 1 0.0294075
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0293415
SEPTIN10 septin 10 0.0290119
EGFR epidermal growth factor receptor 0.0288345
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0287221
PLEC plectin 0.0286319
DOCK1 dedicator of cytokinesis 1 0.0282984
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0282872
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0281549
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0281442
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0280741
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0277541
ZEB1 zinc finger E-box binding homeobox 1 0.0277235
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0274274
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0266692
ANO6 anoctamin 6 0.0266426
NCKAP1 NCK-associated protein 1 0.0265368
CDK13 cyclin-dependent kinase 13 0.0262829
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0262233
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0261736
MDN1 MDN1, midasin homolog (yeast) 0.0261163
SFPQ splicing factor proline/glutamine-rich 0.025992
UPP1 uridine phosphorylase 1 0.0259412
RPTOR regulatory associated protein of MTOR, complex 1 0.0258236
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0257867
MYO10 myosin X 0.025578
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0255094
SND1 staphylococcal nuclease and tudor domain containing 1 0.0254102
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0252409
SRRM2 serine/arginine repetitive matrix 2 0.0251806
NUP58 nucleoporin 58 0.0250804
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0250717

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.328621
RPS16 ribosomal protein S16 -0.290966
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.261749
PTMA prothymosin, alpha -0.18368
TMSB10 thymosin beta 10 -0.130657
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.123904
CD44 CD44 molecule (Indian blood group) -0.0860346
MT2A metallothionein 2A -0.0859686
RPL35A ribosomal protein L35a -0.0827067
S100A6 S100 calcium binding protein A6 -0.0815403
RPLP2 ribosomal protein, large, P2 -0.0756448
RPLP1 ribosomal protein, large, P1 -0.0674311
FTL ferritin, light polypeptide -0.0672394
RPLP0 ribosomal protein, large, P0 -0.0606659
TM4SF1 transmembrane 4 L six family member 1 -0.0554618
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0497309
RPS3 ribosomal protein S3 -0.0488635
RPS8 ribosomal protein S8 -0.0465178
RPS25 ribosomal protein S25 -0.0435118
YBX1 Y box binding protein 1 -0.0427973
ACTG1 actin gamma 1 -0.0412615
RPS6 ribosomal protein S6 -0.0405441
RPL12 ribosomal protein L12 -0.0404209
RPL36A ribosomal protein L36a -0.039356
RPS24 ribosomal protein S24 -0.0392122
B2M beta-2-microglobulin -0.037904
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0378429
TPT1 tumor protein, translationally-controlled 1 -0.0364568
ACTN4 actinin, alpha 4 -0.0361416
S100A10 S100 calcium binding protein A10 -0.0361307
NAP1L1 nucleosome assembly protein 1-like 1 -0.0358743
RPL28 ribosomal protein L28 -0.0357882
EIF1 eukaryotic translation initiation factor 1 -0.034525
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0339758
RPS19 ribosomal protein S19 -0.0337902
KMT2A lysine (K)-specific methyltransferase 2A -0.0335371
UBC ubiquitin C -0.0330458
RPS5 ribosomal protein S5 -0.0330313
RPS13 ribosomal protein S13 -0.0324861
RPS23 ribosomal protein S23 -0.0321468
RPL37A ribosomal protein L37a -0.031479
RPL11 ribosomal protein L11 -0.0313866
WWTR1 WW domain containing transcription regulator 1 -0.0313017
IFITM3 interferon induced transmembrane protein 3 -0.0312078
ANXA2 annexin A2 -0.0311638
ZFP36 ZFP36 ring finger protein -0.0299659
RPS27A ribosomal protein S27a -0.0298661
LGALS1 lectin, galactoside-binding, soluble, 1 -0.029757
RPS21 ribosomal protein S21 -0.0294102
CTSD cathepsin D -0.0290404
RPS12 ribosomal protein S12 -0.0289791
OGA O-GlcNAcase -0.0277958
RTN4 reticulon 4 -0.0277708
RB1CC1 RB1-inducible coiled-coil 1 -0.0277323
HMGA1 high mobility group AT-hook 1 -0.02763
RPL31 ribosomal protein L31 -0.0276069
KLF6 Kruppel-like factor 6 -0.0275372
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0274977
TMEM123 transmembrane protein 123 -0.0273286
WASF2 WAS protein family, member 2 -0.0272696
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0272029
UQCRB ubiquinol-cytochrome c reductase binding protein -0.026952
FOSL1 FOS-like antigen 1 -0.0269061
RPS14 ribosomal protein S14 -0.0268934
C15ORF48 chromosome 15 open reading frame 48 -0.0268494
RPL8 ribosomal protein L8 -0.0266089
PFN1 profilin 1 -0.0264278
SEPTIN7 septin 7 -0.0261109
RPL34 ribosomal protein L34 -0.0259735
RAP1B RAP1B, member of RAS oncogene family -0.025806
GNAS GNAS complex locus -0.0258042
RPL27A ribosomal protein L27a -0.0256451
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0251956
SERF2 small EDRK-rich factor 2 -0.0248744
CDK19 cyclin-dependent kinase 19 -0.024651
HLA-B major histocompatibility complex, class I, B -0.0245413
RPL36 ribosomal protein L36 -0.0243573
PNISR PNN-interacting serine/arginine-rich protein -0.0243513
SBF2 SET binding factor 2 -0.0243323
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0239124
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0239073
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0233849
PERP PERP, TP53 apoptosis effector -0.0233433
ANGPTL4 angiopoietin-like 4 -0.0231767
RPL38 ribosomal protein L38 -0.023126
AFAP1 actin filament associated protein 1 -0.0230339
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0229776
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0222891
UGCG UDP-glucose ceramide glucosyltransferase -0.0216966
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0216833
RPS29 ribosomal protein S29 -0.0214498
VDAC1 voltage-dependent anion channel 1 -0.0214462
RPL9 ribosomal protein L9 -0.0213898
ITGAV integrin, alpha V -0.020927
RPL26 ribosomal protein L26 -0.0208334
SLC38A2 solute carrier family 38, member 2 -0.0206286
LMNA lamin A/C -0.0204899
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0204517
CBX3 chromobox homolog 3 -0.0203669
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -0.0202508