c-Kit-IN-1_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0607006
NAV2 neuron navigator 2 0.053752
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0478443
TSC22D2 TSC22 domain family, member 2 0.0466262
TRIO trio Rho guanine nucleotide exchange factor 0.0458874
SMAD3 SMAD family member 3 0.0454227
FNDC3B fibronectin type III domain containing 3B 0.0364925
INTS6 integrator complex subunit 6 0.0350594
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0346553
MYH9 myosin, heavy chain 9, non-muscle 0.03457
APLP2 amyloid beta (A4) precursor-like protein 2 0.0313363
NRIP1 nuclear receptor interacting protein 1 0.0303423
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0288646
PLEC plectin 0.0287021
ZSWIM6 zinc finger, SWIM-type containing 6 0.0282663
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0282157
TFRC transferrin receptor 0.0279884
SAMD4A sterile alpha motif domain containing 4A 0.0278974
ARHGAP26 Rho GTPase activating protein 26 0.0277129
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0270662
SPAG9 sperm associated antigen 9 0.0265655
ZFAND3 zinc finger, AN1-type domain 3 0.0258345
DSCAM Down syndrome cell adhesion molecule 0.0254098
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0250431
EIF4A2 eukaryotic translation initiation factor 4A2 0.024015
FRMD5 FERM domain containing 5 0.0240048
SHB Src homology 2 domain containing adaptor protein B 0.0236303
DLG1 discs, large homolog 1 (Drosophila) 0.0234487
ATP13A3 ATPase type 13A3 0.0234264
PTK2 protein tyrosine kinase 2 0.0232217
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0230926
ARRDC3 arrestin domain containing 3 0.0227987
GPHN gephyrin 0.0227781
PCLO piccolo presynaptic cytomatrix protein 0.0224147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223703
CCNL1 cyclin L1 0.0222646
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.022261
ANO6 anoctamin 6 0.0221052
MYO5B myosin VB 0.0216008
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0213154
HSPA8 heat shock 70kDa protein 8 0.020926
DST dystonin 0.0201714
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0200343
GSK3B glycogen synthase kinase 3 beta 0.0199792
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0196876
EEF2 eukaryotic translation elongation factor 2 0.019424
RYBP RING1 and YY1 binding protein 0.0191592
MACF1 microtubule-actin crosslinking factor 1 0.018928
SIK3 SIK family kinase 3 0.0188735
BHLHE40 basic helix-loop-helix family, member e40 0.0188547
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0187082
BIRC3 baculoviral IAP repeat containing 3 0.0185392
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0180841
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0179584
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.017941
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0178242
LPP LIM domain containing preferred translocation partner in lipoma 0.0177696
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0177061
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0176676
MYO6 myosin VI 0.0176327
ELOVL5 ELOVL fatty acid elongase 5 0.0175672
USP9X ubiquitin specific peptidase 9, X-linked 0.0174407
ARHGAP29 Rho GTPase activating protein 29 0.0172654
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0169485
ANKRD33B ankyrin repeat domain 33B 0.0167023
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0166216
FNIP1 folliculin interacting protein 1 0.01643
NAMPT nicotinamide phosphoribosyltransferase 0.0163638
APP amyloid beta (A4) precursor protein 0.0160492
FAM107B family with sequence similarity 107, member B 0.0158316
NCKAP1 NCK-associated protein 1 0.0158266
FMNL2 formin-like 2 0.0157086
WNK1 WNK lysine deficient protein kinase 1 0.0156856
SFPQ splicing factor proline/glutamine-rich 0.0155949
BRD2 bromodomain containing 2 0.0155221
ECT2 epithelial cell transforming 2 0.015416
TGM2 transglutaminase 2 0.0153908
AFDN afadin, adherens junction formation factor 0.0153091
CEMIP2 cell migration inducing hyaluronidase 2 0.0151386
EXT1 exostosin glycosyltransferase 1 0.0149776
RLF rearranged L-myc fusion 0.0148826
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0145962
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0144841
CHD1 chromodomain helicase DNA binding protein 1 0.0142687
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0142152
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0140401
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0138766
ELL2 elongation factor, RNA polymerase II, 2 0.0138032
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0137392
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0137267
SOD2 superoxide dismutase 2, mitochondrial 0.0137197
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0136549
FLNA filamin A, alpha 0.0135801
FAR1 fatty acyl CoA reductase 1 0.013562
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0135357
CKAP5 cytoskeleton associated protein 5 0.0134579
PPARD peroxisome proliferator-activated receptor delta 0.0134457
NUP58 nucleoporin 58 0.0132453
YAP1 Yes-associated protein 1 0.0132257
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.013079

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162575
TPT1 tumor protein, translationally-controlled 1 -0.116709
PTMA prothymosin, alpha -0.112753
RPS6 ribosomal protein S6 -0.101833
TMSB10 thymosin beta 10 -0.0846165
RPL35A ribosomal protein L35a -0.0719991
ACTG1 actin gamma 1 -0.0692584
HMGA1 high mobility group AT-hook 1 -0.0676587
RPS8 ribosomal protein S8 -0.0665273
RPLP1 ribosomal protein, large, P1 -0.06125
LAMA4 laminin, alpha 4 -0.0607274
RPS19 ribosomal protein S19 -0.0588167
RPS13 ribosomal protein S13 -0.0581963
TMSB4X thymosin beta 4, X-linked -0.056555
RPS3 ribosomal protein S3 -0.0538418
KRT19 keratin 19, type I -0.0521919
RPL37A ribosomal protein L37a -0.0510899
RPL23 ribosomal protein L23 -0.0505095
RPL12 ribosomal protein L12 -0.0503198
FN1 fibronectin 1 -0.0501051
B2M beta-2-microglobulin -0.0495434
FTL ferritin, light polypeptide -0.0480041
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0464978
TPM4 tropomyosin 4 -0.0461788
IFI27 interferon, alpha-inducible protein 27 -0.0457976
HLA-B major histocompatibility complex, class I, B -0.0454958
IGFBP3 insulin-like growth factor binding protein 3 -0.04541
RACK1 receptor for activated C kinase 1 -0.0449433
RPL19 ribosomal protein L19 -0.0447857
RPS29 ribosomal protein S29 -0.044276
RPL31 ribosomal protein L31 -0.0425987
RPS23 ribosomal protein S23 -0.042534
RPS27A ribosomal protein S27a -0.0405951
RPL34 ribosomal protein L34 -0.040144
MT2A metallothionein 2A -0.0401412
DSG2 desmoglein 2 -0.0400593
LMO7 LIM domain 7 -0.0399582
RPS14 ribosomal protein S14 -0.0398344
S100A6 S100 calcium binding protein A6 -0.0393629
RPS21 ribosomal protein S21 -0.0378542
RPL37 ribosomal protein L37 -0.0376587
RPL8 ribosomal protein L8 -0.037496
RPS12 ribosomal protein S12 -0.0373022
RPS15 ribosomal protein S15 -0.0369904
RPL36 ribosomal protein L36 -0.0368153
RPL28 ribosomal protein L28 -0.0366969
KRT7 keratin 7, type II -0.0359775
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0358814
EIF1 eukaryotic translation initiation factor 1 -0.0355101
LY6E lymphocyte antigen 6 complex, locus E -0.0349052
CD2AP CD2-associated protein -0.0344299
RPS25 ribosomal protein S25 -0.0336598
RPLP2 ribosomal protein, large, P2 -0.031536
RPL26 ribosomal protein L26 -0.0315239
RPL36A ribosomal protein L36a -0.0315048
POTEF POTE ankyrin domain family, member F -0.0306325
MAML2 mastermind-like 2 (Drosophila) -0.0304925
RPS17 ribosomal protein S17 -0.0294181
SOX4 SRY (sex determining region Y)-box 4 -0.0293425
TPI1 triosephosphate isomerase 1 -0.0290622
RPL11 ribosomal protein L11 -0.0289258
RPS24 ribosomal protein S24 -0.0286642
RPL35 ribosomal protein L35 -0.0278545
RPL9 ribosomal protein L9 -0.0276169
RPS27 ribosomal protein S27 -0.0273134
IFITM3 interferon induced transmembrane protein 3 -0.0272203
TM4SF1 transmembrane 4 L six family member 1 -0.0269676
RPS10 ribosomal protein S10 -0.0267581
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0265818
RPS11 ribosomal protein S11 -0.0264026
IFITM1 interferon induced transmembrane protein 1 -0.0263622
RPL38 ribosomal protein L38 -0.0259941
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.025993
F3 coagulation factor III (thromboplastin, tissue factor) -0.0259629
RPL32 ribosomal protein L32 -0.0257169
ANXA2 annexin A2 -0.0253772
EMP1 epithelial membrane protein 1 -0.0253339
HLA-A major histocompatibility complex, class I, A -0.0251008
RPS5 ribosomal protein S5 -0.0248901
EGR1 early growth response 1 -0.0248492
WFDC2 WAP four-disulfide core domain 2 -0.0246671
PLAUR plasminogen activator, urokinase receptor -0.0242772
S100A11 S100 calcium binding protein A11 -0.0239558
RPL5 ribosomal protein L5 -0.0238786
S100A10 S100 calcium binding protein A10 -0.0237919
MX2 MX dynamin-like GTPase 2 -0.0237696
C6ORF132 chromosome 6 open reading frame 132 -0.0233302
G0S2 G0/G1 switch 2 -0.0233204
LOC102724023 ES1 protein homolog, mitochondrial -0.0232798
S100A9 S100 calcium binding protein A9 -0.0229698
RPL13A ribosomal protein L13a -0.0228034
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0227154
RPS16 ribosomal protein S16 -0.02259
MUC4 mucin 4, cell surface associated -0.0225067
VIM vimentin -0.0224994
NPEPPS aminopeptidase puromycin sensitive -0.0224074
RPL30 ribosomal protein L30 -0.0213016
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.020763
PLAT plasminogen activator, tissue -0.0205787
RPL18 ribosomal protein L18 -0.0203754