c-Kit-IN-1_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTK2 protein tyrosine kinase 2 0.0902681
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.086419
ZFAND3 zinc finger, AN1-type domain 3 0.0853745
NUP58 nucleoporin 58 0.0815819
ATP13A3 ATPase type 13A3 0.0792443
EEF2 eukaryotic translation elongation factor 2 0.0720908
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0702199
ANK2 ankyrin 2, neuronal 0.0700339
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0689363
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0668957
MCTP1 multiple C2 domains, transmembrane 1 0.0654542
GARS1 glycyl-tRNA synthetase 1 0.0644586
SFPQ splicing factor proline/glutamine-rich 0.0630275
PRRC2B proline-rich coiled-coil 2B 0.061943
FMNL2 formin-like 2 0.0613666
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.059562
COG5 component of oligomeric golgi complex 5 0.0578211
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0570034
TFRC transferrin receptor 0.0568112
APP amyloid beta (A4) precursor protein 0.0549586
WDR43 WD repeat domain 43 0.054663
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0543696
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0526612
SRRM2 serine/arginine repetitive matrix 2 0.0519685
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0516103
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0514934
EXT1 exostosin glycosyltransferase 1 0.0504162
TXNRD1 thioredoxin reductase 1 0.0500611
TPD52 tumor protein D52 0.0496301
STK4 serine/threonine kinase 4 0.049194
UPP1 uridine phosphorylase 1 0.0491495
NAMPT nicotinamide phosphoribosyltransferase 0.049118
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0482914
CHD7 chromodomain helicase DNA binding protein 7 0.0481645
PUM1 pumilio RNA-binding family member 1 0.0478582
SND1 staphylococcal nuclease and tudor domain containing 1 0.0471255
MCL1 myeloid cell leukemia 1 0.0470319
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0467321
NCKAP1 NCK-associated protein 1 0.0463618
CLTC clathrin, heavy chain (Hc) 0.0463527
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0461721
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0457587
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0444545
CORO1C coronin, actin binding protein, 1C 0.0441132
USP34 ubiquitin specific peptidase 34 0.0435924
GMDS GDP-mannose 4,6-dehydratase 0.043548
WAC WW domain containing adaptor with coiled-coil 0.0435223
GPHN gephyrin 0.0431359
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0430993
BIRC6 baculoviral IAP repeat containing 6 0.0429155
FAM91A1 family with sequence similarity 91, member A1 0.0421187
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0415537
SRPK2 SRSF protein kinase 2 0.0412441
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0410653
CCNY cyclin Y 0.0410501
USP9X ubiquitin specific peptidase 9, X-linked 0.0409581
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0409024
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0406695
MYH9 myosin, heavy chain 9, non-muscle 0.0405536
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0400393
OTUD4 OTU deubiquitinase 4 0.0399385
RLF rearranged L-myc fusion 0.0387941
SGMS2 sphingomyelin synthase 2 0.0386718
ECPAS Ecm29 proteasome adaptor and scaffold 0.0384378
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0383025
RAB7A RAB7A, member RAS oncogene family 0.037707
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0376049
CCNL1 cyclin L1 0.0373689
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.0372174
CREB5 cAMP responsive element binding protein 5 0.0371769
CAPRIN2 caprin family member 2 0.036995
RCOR1 REST corepressor 1 0.0368199
HSPA8 heat shock 70kDa protein 8 0.0367407
RUNX1 runt-related transcription factor 1 0.0366796
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0365593
FNIP1 folliculin interacting protein 1 0.0363005
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0358868
STC1 stanniocalcin 1 0.0358093
PCNX1 pecanex 1 0.0353452
IARS1 isoleucyl-tRNA synthetase 1 0.0353033
FAR1 fatty acyl CoA reductase 1 0.0350859
FNDC3B fibronectin type III domain containing 3B 0.0348826
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0347119
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.034711
SAMD4A sterile alpha motif domain containing 4A 0.0343955
ZBTB43 zinc finger and BTB domain containing 43 0.0342394
CYRIB CYFIP related Rac1 interactor B 0.0341293
KMT2C lysine (K)-specific methyltransferase 2C 0.0339935
DSCAM Down syndrome cell adhesion molecule 0.0339502
XPO1 exportin 1 0.0333596
ZNF800 zinc finger protein 800 0.0332822
ZEB1 zinc finger E-box binding homeobox 1 0.0329731
TM4SF19 transmembrane 4 L six family member 19 0.0327712
SPAG9 sperm associated antigen 9 0.0325967
RTN4 reticulon 4 0.0322109
USP3 ubiquitin specific peptidase 3 0.0319072
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0318533
UBA6 ubiquitin-like modifier activating enzyme 6 0.0317995
ELL2 elongation factor, RNA polymerase II, 2 0.0317783
AGO2 argonaute RISC catalytic component 2 0.0317242

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.146583
RPS6 ribosomal protein S6 -0.120949
MT2A metallothionein 2A -0.0975774
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0943395
RPS8 ribosomal protein S8 -0.0901241
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0685486
IFI16 interferon, gamma-inducible protein 16 -0.0673356
ZNF438 zinc finger protein 438 -0.0661341
TPT1 tumor protein, translationally-controlled 1 -0.0658642
RPS3 ribosomal protein S3 -0.0588492
FTL ferritin, light polypeptide -0.0550156
HMGA2 high mobility group AT-hook 2 -0.054811
BNC2 basonuclin 2 -0.0519326
FRMD4A FERM domain containing 4A -0.0510196
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0507099
RPL8 ribosomal protein L8 -0.048592
HMGA1 high mobility group AT-hook 1 -0.0475088
RPLP1 ribosomal protein, large, P1 -0.0472018
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0468788
SLC38A2 solute carrier family 38, member 2 -0.0467543
CALD1 caldesmon 1 -0.0462749
RPS27A ribosomal protein S27a -0.045895
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0458412
RPS19 ribosomal protein S19 -0.0450426
RPL9 ribosomal protein L9 -0.0448815
RPL12 ribosomal protein L12 -0.0441238
RPS12 ribosomal protein S12 -0.0440651
RPLP2 ribosomal protein, large, P2 -0.0435824
RPL37A ribosomal protein L37a -0.0426849
RPL11 ribosomal protein L11 -0.0422684
RPL23 ribosomal protein L23 -0.040362
RPS29 ribosomal protein S29 -0.0398138
RPS17 ribosomal protein S17 -0.039755
RPS13 ribosomal protein S13 -0.0391383
RPL35 ribosomal protein L35 -0.0387305
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0385546
TTR transthyretin -0.0376926
SP100 SP100 nuclear antigen -0.0376205
MTAP methylthioadenosine phosphorylase -0.0374922
RPL22L1 ribosomal protein L22-like 1 -0.0372528
RPLP0 ribosomal protein, large, P0 -0.0367647
RPL19 ribosomal protein L19 -0.0362343
PTMA prothymosin, alpha -0.0350706
RPL26 ribosomal protein L26 -0.0350248
RPS21 ribosomal protein S21 -0.0348321
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0344137
NABP1 nucleic acid binding protein 1 -0.0334559
RIGI RNA sensor RIG-I -0.0327862
RPS23 ribosomal protein S23 -0.0325052
RPS2 ribosomal protein S2 -0.0323136
RPL35A ribosomal protein L35a -0.032233
ZBTB20 zinc finger and BTB domain containing 20 -0.0313069
RPL34 ribosomal protein L34 -0.030123
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0298599
FLNB filamin B, beta -0.0297912
POTEF POTE ankyrin domain family, member F -0.0295047
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0293461
RPS15 ribosomal protein S15 -0.028622
RPL31 ribosomal protein L31 -0.0285225
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0283177
PCNX4 pecanex 4 -0.0279002
RPS11 ribosomal protein S11 -0.0275618
RPS25 ribosomal protein S25 -0.027544
ASPH aspartate beta-hydroxylase -0.027133
ANTXR2 anthrax toxin receptor 2 -0.0266049
RPL28 ribosomal protein L28 -0.0265329
RPL38 ribosomal protein L38 -0.0264396
RPS27 ribosomal protein S27 -0.0263848
RPS20 ribosomal protein S20 -0.0262684
RPL13A ribosomal protein L13a -0.0262084
RPS14 ribosomal protein S14 -0.0258512
NAP1L1 nucleosome assembly protein 1-like 1 -0.0251572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.025126
AKAP9 A kinase (PRKA) anchor protein 9 -0.0250971
RB1CC1 RB1-inducible coiled-coil 1 -0.0248676
RAD51B RAD51 paralog B -0.0246659
RPL36 ribosomal protein L36 -0.0245578
RPL27A ribosomal protein L27a -0.0241602
TRIM56 tripartite motif containing 56 -0.0236167
RPS10 ribosomal protein S10 -0.0234742
CCDC91 coiled-coil domain containing 91 -0.0231968
IFI6 interferon, alpha-inducible protein 6 -0.0230687
RPL27 ribosomal protein L27 -0.0226002
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0225731
RPL37 ribosomal protein L37 -0.022454
RPS5 ribosomal protein S5 -0.022183
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0219882
RAB3IP RAB3A interacting protein -0.0219243
RPS24 ribosomal protein S24 -0.0218544
DGKI diacylglycerol kinase, iota -0.0215553
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0214939
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0212179
TMSB10 thymosin beta 10 -0.0207321
TNRC6B trinucleotide repeat containing 6B -0.0202932
S100A2 S100 calcium binding protein A2 -0.0201967
PFN1 profilin 1 -0.0201619
ACTG1 actin gamma 1 -0.0201397
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.020029
RPL36A ribosomal protein L36a -0.0199406
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0197557