c-Kit-IN-1_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.279721
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.151039
PGK1 phosphoglycerate kinase 1 0.127951
CXCL8 chemokine (C-X-C motif) ligand 8 0.0942474
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0899384
STC1 stanniocalcin 1 0.0859626
NAMPT nicotinamide phosphoribosyltransferase 0.0843463
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0790377
CD109 CD109 molecule 0.0785638
NDRG1 N-myc downstream regulated 1 0.0775111
ATP13A3 ATPase type 13A3 0.0767785
GOLGA4 golgin A4 0.0738571
BHLHE40 basic helix-loop-helix family, member e40 0.0734676
UBA6 ubiquitin-like modifier activating enzyme 6 0.0721345
COL6A1 collagen, type VI, alpha 1 0.071616
ANXA2 annexin A2 0.0712634
GARS1 glycyl-tRNA synthetase 1 0.0698399
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0679172
FAT1 FAT atypical cadherin 1 0.0664257
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.066316
TRIO trio Rho guanine nucleotide exchange factor 0.0590678
COL1A2 collagen, type I, alpha 2 0.0587754
MACF1 microtubule-actin crosslinking factor 1 0.0544859
SOD2 superoxide dismutase 2, mitochondrial 0.0541006
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0527531
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0514223
DLG1 discs, large homolog 1 (Drosophila) 0.0497194
MYO1B myosin IB 0.0484468
FRMD5 FERM domain containing 5 0.0483017
ZBTB38 zinc finger and BTB domain containing 38 0.0477465
JARID2 jumonji, AT rich interactive domain 2 0.045648
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0456472
RLF rearranged L-myc fusion 0.0455073
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0445105
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0444899
ZNF292 zinc finger protein 292 0.0440791
SFTPA2 surfactant protein A2 0.0436496
LOXL2 lysyl oxidase-like 2 0.0429644
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0429247
YEATS2 YEATS domain containing 2 0.0427953
FTH1 ferritin, heavy polypeptide 1 0.0426071
MSR1 macrophage scavenger receptor 1 0.0423215
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0422515
NRIP1 nuclear receptor interacting protein 1 0.041753
NUP58 nucleoporin 58 0.0407903
WAC WW domain containing adaptor with coiled-coil 0.0406498
WNT5A wingless-type MMTV integration site family, member 5A 0.0399156
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0397227
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0396223
CCNL1 cyclin L1 0.0393277
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0391671
AFF4 AF4/FMR2 family, member 4 0.0390928
FAM162A family with sequence similarity 162, member A 0.0389317
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0388904
RND3 Rho family GTPase 3 0.0383363
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0380764
ELL2 elongation factor, RNA polymerase II, 2 0.0377835
KIAA1217 KIAA1217 0.0375035
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0374344
TRA2A transformer 2 alpha homolog (Drosophila) 0.0374107
NRP1 neuropilin 1 0.0373215
PLEC plectin 0.0359604
RAB7A RAB7A, member RAS oncogene family 0.0358823
HOOK2 hook microtubule-tethering protein 2 0.0357904
PTPRG protein tyrosine phosphatase, receptor type, G 0.0356428
EXT1 exostosin glycosyltransferase 1 0.0355064
DST dystonin 0.0351899
CTSB cathepsin B 0.0350484
TPD52 tumor protein D52 0.0347483
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0346536
INHBA inhibin, beta A 0.0345097
EML5 echinoderm microtubule associated protein like 5 0.0343436
GNPDA1 glucosamine-6-phosphate deaminase 1 0.033737
ANKRD28 ankyrin repeat domain 28 0.033456
RYBP RING1 and YY1 binding protein 0.0333074
ANO6 anoctamin 6 0.0332117
TFG TRK-fused gene 0.0331734
TGM2 transglutaminase 2 0.0329558
PDE4D phosphodiesterase 4D, cAMP-specific 0.0328717
BACE2 beta-site APP-cleaving enzyme 2 0.0325642
YME1L1 YME1-like 1 ATPase 0.0319107
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0318732
ARL4C ADP-ribosylation factor-like 4C 0.0318143
PRRC2C proline-rich coiled-coil 2C 0.0317165
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0315294
RLIM ring finger protein, LIM domain interacting 0.0314215
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0313989
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0313971
FMNL2 formin-like 2 0.0313699
COL6A2 collagen, type VI, alpha 2 0.0312833
MIMS1 mitochondrial inner membrane scaffold 1 0.0310817
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0308664
USP3 ubiquitin specific peptidase 3 0.0308244
ANK2 ankyrin 2, neuronal 0.030509
RAB18 RAB18, member RAS oncogene family 0.0304501
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0302886
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0302258
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0302013
SVIL supervillin 0.030169
BRWD3 bromodomain and WD repeat domain containing 3 0.0301222

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.23036
UBC ubiquitin C -0.0949086
MT2A metallothionein 2A -0.0907476
CDH13 cadherin 13 -0.0834241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0829364
RPS27A ribosomal protein S27a -0.0777768
TMSB10 thymosin beta 10 -0.0724548
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0677741
FRMD4A FERM domain containing 4A -0.059739
PTMA prothymosin, alpha -0.0578907
COL1A1 collagen, type I, alpha 1 -0.0538612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0520816
CENPF centromere protein F, 350/400kDa -0.0496509
FAM20C family with sequence similarity 20, member C -0.0494354
RPS6 ribosomal protein S6 -0.0457493
ENO1 enolase 1, (alpha) -0.0440091
RPL37A ribosomal protein L37a -0.040017
TNS3 tensin 3 -0.0395833
HMGB2 high mobility group box 2 -0.0377667
RPLP2 ribosomal protein, large, P2 -0.0375098
RPS3 ribosomal protein S3 -0.0357262
COL7A1 collagen, type VII, alpha 1 -0.0349823
PSD3 pleckstrin and Sec7 domain containing 3 -0.0340443
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0338207
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0329365
TPT1 tumor protein, translationally-controlled 1 -0.0318507
SCLT1 sodium channel and clathrin linker 1 -0.0316929
RPL23 ribosomal protein L23 -0.0306848
RPL12 ribosomal protein L12 -0.0304403
POTEF POTE ankyrin domain family, member F -0.0303523
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0302418
RPS8 ribosomal protein S8 -0.0290623
RPS17 ribosomal protein S17 -0.0282842
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0276386
RPS19 ribosomal protein S19 -0.0275021
MCL1 myeloid cell leukemia 1 -0.0270984
RPS13 ribosomal protein S13 -0.0268429
RPL13A ribosomal protein L13a -0.0266867
RPLP1 ribosomal protein, large, P1 -0.0258131
TPX2 TPX2, microtubule-associated -0.025789
ZMYND8 zinc finger, MYND-type containing 8 -0.0256628
RPL26 ribosomal protein L26 -0.0255658
RPS29 ribosomal protein S29 -0.0253228
RPS23 ribosomal protein S23 -0.0248689
MBD5 methyl-CpG binding domain protein 5 -0.0248509
RAD51B RAD51 paralog B -0.0242815
FKBP1A FK506 binding protein 1A, 12kDa -0.0240428
CENPE centromere protein E, 312kDa -0.0235052
OGA O-GlcNAcase -0.023
XRN1 5'-3' exoribonuclease 1 -0.022796
ACTG1 actin gamma 1 -0.0223373
EGFR epidermal growth factor receptor -0.0221143
RPL28 ribosomal protein L28 -0.0220447
RPL9 ribosomal protein L9 -0.0220299
YBX1 Y box binding protein 1 -0.0213951
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0209715
RPS11 ribosomal protein S11 -0.0207331
LMO7 LIM domain 7 -0.0204781
RPS5 ribosomal protein S5 -0.0204666
NCOA1 nuclear receptor coactivator 1 -0.0202895
RPS16 ribosomal protein S16 -0.0201115
RPL8 ribosomal protein L8 -0.0199764
SRSF11 serine/arginine-rich splicing factor 11 -0.0193387
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0192969
PDIA4 protein disulfide isomerase family A, member 4 -0.0191315
SMC4 structural maintenance of chromosomes 4 -0.0189998
SPDYA speedy/RINGO cell cycle regulator family member A -0.0189809
RPL37 ribosomal protein L37 -0.0189094
SERINC3 serine incorporator 3 -0.0188819
NPAS2 neuronal PAS domain protein 2 -0.018626
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0183381
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0182698
IL1B interleukin 1, beta -0.0181919
BRWD1 bromodomain and WD repeat domain containing 1 -0.0181474
BBX bobby sox homolog (Drosophila) -0.0179348
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0179049
RPL36 ribosomal protein L36 -0.0177426
RPL31 ribosomal protein L31 -0.0177204
TNRC6B trinucleotide repeat containing 6B -0.0176503
CDC25B cell division cycle 25B -0.0174743
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.017385
APOLD1 apolipoprotein L domain containing 1 -0.0172111
SLC38A2 solute carrier family 38, member 2 -0.0167656
SERF2 small EDRK-rich factor 2 -0.0166892
NEK7 NIMA-related kinase 7 -0.0165527
RACK1 receptor for activated C kinase 1 -0.0165227
AGBL1 ATP/GTP binding protein-like 1 -0.0164522
TENM1 teneurin transmembrane protein 1 -0.0164132
RPS25 ribosomal protein S25 -0.0163587
RB1CC1 RB1-inducible coiled-coil 1 -0.0162734
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0162371
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0162048
TLN1 talin 1 -0.0161607
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0160382
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0159062
NABP1 nucleic acid binding protein 1 -0.0158198
CD44 CD44 molecule (Indian blood group) -0.0157331
INTS6 integrator complex subunit 6 -0.0155518
IPO9 importin 9 -0.01544
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.015302