| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | c-Kit-IN-1 perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the c-Kit-IN-1_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPC6 | glypican 6 | 0.175725 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.113401 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0631284 |
| CNTNAP2 | contactin associated protein-like 2 | 0.0620325 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.059402 |
| DTNA | dystrobrevin, alpha | 0.0586505 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0570599 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0548387 |
| NDRG1 | N-myc downstream regulated 1 | 0.0527916 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0495243 |
| AGMO | alkylglycerol monooxygenase | 0.0473917 |
| PTK2 | protein tyrosine kinase 2 | 0.0471546 |
| MSI2 | musashi RNA-binding protein 2 | 0.0458101 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.044506 |
| LSAMP | limbic system-associated membrane protein | 0.0443719 |
| TUSC3 | tumor suppressor candidate 3 | 0.0434625 |
| SNTG1 | syntrophin, gamma 1 | 0.0430107 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0422079 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0414609 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0409464 |
| NUP58 | nucleoporin 58 | 0.0404252 |
| HDAC9 | histone deacetylase 9 | 0.0390261 |
| RORA | RAR-related orphan receptor A | 0.0384117 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0367573 |
| SCFD2 | sec1 family domain containing 2 | 0.0359647 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0348288 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0346857 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0345563 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | 0.0342973 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0340074 |
| TENM1 | teneurin transmembrane protein 1 | 0.0339477 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0338132 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.033075 |
| NELL1 | NEL-like 1 (chicken) | 0.032039 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.031704 |
| NRG1 | neuregulin 1 | 0.031696 |
| KIF26B | kinesin family member 26B | 0.0310465 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0309211 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.03063 |
| PGK1 | phosphoglycerate kinase 1 | 0.0304503 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0299664 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0299315 |
| PALS2 | protein associated with LIN7 2, MAGUK p55 family member | 0.0298477 |
| FAT1 | FAT atypical cadherin 1 | 0.0291202 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0288717 |
| WDR45B | WD repeat domain 45B | 0.0285394 |
| DNM3 | dynamin 3 | 0.0281543 |
| ZNF804A | zinc finger protein 804A | 0.0270255 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | 0.0265337 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0261193 |
| NBEA | neurobeachin | 0.0260161 |
| GPATCH2L | G patch domain containing 2-like | 0.0259436 |
| ZMAT4 | zinc finger, matrin-type 4 | 0.0258732 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0256211 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0255346 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0254427 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0253946 |
| CLSTN2 | calsyntenin 2 | 0.0252263 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0251739 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0246014 |
| MIPOL1 | mirror-image polydactyly 1 | 0.0245537 |
| APP | amyloid beta (A4) precursor protein | 0.0243044 |
| PUM3 | pumilio RNA binding family member 3 | 0.0242778 |
| NF1 | neurofibromin 1 | 0.0242604 |
| WDR43 | WD repeat domain 43 | 0.0241365 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0241095 |
| IPO5 | importin 5 | 0.0239044 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0238041 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.0237794 |
| SQSTM1 | sequestosome 1 | 0.023742 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0237126 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0237077 |
| EPHA6 | EPH receptor A6 | 0.0233845 |
| GPHN | gephyrin | 0.0232042 |
| GRIK5 | glutamate receptor, ionotropic, kainate 5 | 0.0231287 |
| ATP11A | ATPase, class VI, type 11A | 0.0231273 |
| XPO6 | exportin 6 | 0.0230904 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.0227075 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | 0.0225498 |
| MDN1 | MDN1, midasin homolog (yeast) | 0.0222543 |
| CADM1 | cell adhesion molecule 1 | 0.0222321 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0219518 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0218526 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0217947 |
| BMERB1 | bMERB domain containing 1 | 0.0216884 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0216716 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0215951 |
| DST | dystonin | 0.0215334 |
| GPAT4 | glycerol-3-phosphate acyltransferase 4 | 0.0214353 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0212658 |
| URB1 | URB1 ribosome biogenesis 1 homolog (S. cerevisiae) | 0.0212577 |
| YTHDF3 | YTH N(6)-methyladenosine RNA binding protein 3 | 0.0210391 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0209957 |
| KLHL29 | kelch-like family member 29 | 0.0207129 |
| DGKB | diacylglycerol kinase, beta 90kDa | 0.0206754 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0204985 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0204286 |
| FMNL2 | formin-like 2 | 0.0203563 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0202827 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0202814 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.206895 |
| PTMA | prothymosin, alpha | -0.125771 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.121715 |
| CENPF | centromere protein F, 350/400kDa | -0.112122 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0850473 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0841491 |
| CALCA | calcitonin-related polypeptide alpha | -0.0783769 |
| FTL | ferritin, light polypeptide | -0.074831 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0725446 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0631871 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0596396 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0576217 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0560469 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0525698 |
| MT2A | metallothionein 2A | -0.0524285 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0517549 |
| CPE | carboxypeptidase E | -0.0517149 |
| IRS2 | insulin receptor substrate 2 | -0.049751 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.0459392 |
| RPS6 | ribosomal protein S6 | -0.045843 |
| NCKAP5 | NCK-associated protein 5 | -0.0449451 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0442739 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0441104 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0436971 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0436617 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0428786 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0424749 |
| RPS8 | ribosomal protein S8 | -0.0403456 |
| EGR1 | early growth response 1 | -0.0402369 |
| SYT1 | synaptotagmin I | -0.0401407 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0396836 |
| POTEF | POTE ankyrin domain family, member F | -0.0386047 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.0381483 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0381026 |
| RPS27A | ribosomal protein S27a | -0.0376675 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0372152 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0368008 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0364475 |
| SYT4 | synaptotagmin IV | -0.0360351 |
| FOXN3 | forkhead box N3 | -0.035885 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0355083 |
| RTN4 | reticulon 4 | -0.0352971 |
| RIT2 | Ras-like without CAAX 2 | -0.0352013 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0347367 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0340946 |
| NFIA | nuclear factor I/A | -0.0340549 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0340144 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.033869 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0330822 |
| RPL8 | ribosomal protein L8 | -0.0318969 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0312846 |
| PKM | pyruvate kinase, muscle | -0.0310572 |
| RNF213 | ring finger protein 213 | -0.0308115 |
| FOXP1 | forkhead box P1 | -0.0308052 |
| ZNF292 | zinc finger protein 292 | -0.0307405 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0306438 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0304026 |
| STMN1 | stathmin 1 | -0.0303066 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0300498 |
| KLHL24 | kelch-like family member 24 | -0.0297364 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | -0.029663 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.029659 |
| B2M | beta-2-microglobulin | -0.0295966 |
| RPL19 | ribosomal protein L19 | -0.0294939 |
| S100A9 | S100 calcium binding protein A9 | -0.0288327 |
| RPS3 | ribosomal protein S3 | -0.028673 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0284262 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.028173 |
| FOXC1 | forkhead box C1 | -0.028105 |
| CDH12 | cadherin 12, type 2 (N-cadherin 2) | -0.028103 |
| RPLP1 | ribosomal protein, large, P1 | -0.0277794 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0274471 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0273131 |
| PEG10 | paternally expressed 10 | -0.0267146 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0266534 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0266233 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0265231 |
| FGF14 | fibroblast growth factor 14 | -0.0263996 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0263604 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0262887 |
| HMGB2 | high mobility group box 2 | -0.0262039 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0258442 |
| BBX | bobby sox homolog (Drosophila) | -0.0258019 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -0.0257512 |
| CNKSR3 | CNKSR family member 3 | -0.0257233 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | -0.0256038 |
| ESRRG | estrogen-related receptor gamma | -0.0252911 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0252585 |
| GPRIN3 | GPRIN family member 3 | -0.025004 |
| VGF | VGF nerve growth factor inducible | -0.0248987 |
| TMSB10 | thymosin beta 10 | -0.0248926 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0247186 |
| ETV1 | ets variant 1 | -0.0246631 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0246424 |
| RPS21 | ribosomal protein S21 | -0.024383 |
| UBC | ubiquitin C | -0.0240871 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0239352 |
| SMAD9 | SMAD family member 9 | -0.0238685 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0238367 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0235965 |
