c-Kit-IN-1_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.144179
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.124
SLC39A11 solute carrier family 39, member 11 0.11157
MSI2 musashi RNA-binding protein 2 0.0759005
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0712733
TXNRD1 thioredoxin reductase 1 0.0650631
ZFAND3 zinc finger, AN1-type domain 3 0.0630752
PTPRG protein tyrosine phosphatase, receptor type, G 0.0602841
LSAMP limbic system-associated membrane protein 0.0585065
FMNL2 formin-like 2 0.0579582
NAV2 neuron navigator 2 0.0554672
FNDC3B fibronectin type III domain containing 3B 0.0553016
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0550421
NAMPT nicotinamide phosphoribosyltransferase 0.0549798
FRMD4A FERM domain containing 4A 0.0526662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0506376
ANKRD11 ankyrin repeat domain 11 0.0505689
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0487631
PRELID2 PRELI domain containing 2 0.0483152
NRG3 neuregulin 3 0.0462365
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0447979
ASPH aspartate beta-hydroxylase 0.0444246
CXCL8 chemokine (C-X-C motif) ligand 8 0.0438343
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0427795
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0422855
LINGO2 leucine rich repeat and Ig domain containing 2 0.041202
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0411197
TRIO trio Rho guanine nucleotide exchange factor 0.0407857
ATP13A3 ATPase type 13A3 0.0401919
TFRC transferrin receptor 0.0399208
DST dystonin 0.0391941
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0391637
SPAG9 sperm associated antigen 9 0.0390992
CHD1 chromodomain helicase DNA binding protein 1 0.0387688
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0387368
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0386276
GPHN gephyrin 0.0382782
DLG1 discs, large homolog 1 (Drosophila) 0.0379318
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0379101
ELL2 elongation factor, RNA polymerase II, 2 0.0375087
GARS1 glycyl-tRNA synthetase 1 0.0373491
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0368931
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0360223
BACE2 beta-site APP-cleaving enzyme 2 0.0358494
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0357599
FSTL5 follistatin-like 5 0.0354578
SEPTIN9 septin 9 0.0339207
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0339084
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332882
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.033081
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330014
CA8 carbonic anhydrase VIII 0.0329539
KAZN kazrin, periplakin interacting protein 0.0327915
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0327583
LAMP2 lysosomal-associated membrane protein 2 0.0324289
NOTCH2 notch 2 0.0322948
COG5 component of oligomeric golgi complex 5 0.031905
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.0316133
PTPRM protein tyrosine phosphatase, receptor type, M 0.0315671
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0312808
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.03101
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0309682
RYBP RING1 and YY1 binding protein 0.0301747
FHIT fragile histidine triad 0.0300218
IPO7 importin 7 0.0300088
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0297516
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0296548
PTK2 protein tyrosine kinase 2 0.0296294
ADAM17 ADAM metallopeptidase domain 17 0.0291952
TUSC3 tumor suppressor candidate 3 0.0290377
SFTPA2 surfactant protein A2 0.0288252
FLNB filamin B, beta 0.0287484
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0287274
SOD2 superoxide dismutase 2, mitochondrial 0.0286908
SMYD3 SET and MYND domain containing 3 0.0280698
SND1 staphylococcal nuclease and tudor domain containing 1 0.0280421
SMAD3 SMAD family member 3 0.0279545
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.027917
FLNA filamin A, alpha 0.0278089
MAP4 microtubule-associated protein 4 0.0273749
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0273237
UBA6 ubiquitin-like modifier activating enzyme 6 0.0271645
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0271595
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0270368
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0267616
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0267104
NBAS neuroblastoma amplified sequence 0.0262653
NAP1L1 nucleosome assembly protein 1-like 1 0.0259757
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0259343
ZNF638 zinc finger protein 638 0.0258831
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0256552
GMDS GDP-mannose 4,6-dehydratase 0.0255198
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0254309
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0253149
ENAH enabled homolog (Drosophila) 0.0252701
CORO1C coronin, actin binding protein, 1C 0.025192
MYH9 myosin, heavy chain 9, non-muscle 0.0251601
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0251483
MARCHF1 membrane associated ring-CH-type finger 1 0.0251259
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0250808

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.139789
VIM vimentin -0.138593
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100603
RPS3 ribosomal protein S3 -0.0588495
RPS6 ribosomal protein S6 -0.0534791
TMSB10 thymosin beta 10 -0.0486837
FTL ferritin, light polypeptide -0.0459868
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0438488
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.038546
RPL35A ribosomal protein L35a -0.03839
NLGN1 neuroligin 1 -0.0376362
MT2A metallothionein 2A -0.035329
PTMA prothymosin, alpha -0.0345718
B2M beta-2-microglobulin -0.0333942
IFI6 interferon, alpha-inducible protein 6 -0.0320261
POTEF POTE ankyrin domain family, member F -0.0291
RPS13 ribosomal protein S13 -0.0290355
TPT1 tumor protein, translationally-controlled 1 -0.028748
RPLP1 ribosomal protein, large, P1 -0.0279781
RPS21 ribosomal protein S21 -0.0271836
RPL31 ribosomal protein L31 -0.027122
RPL19 ribosomal protein L19 -0.0266639
HLA-B major histocompatibility complex, class I, B -0.0264824
RPLP2 ribosomal protein, large, P2 -0.0254864
RPL34 ribosomal protein L34 -0.0253882
RPL37A ribosomal protein L37a -0.0252662
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0239506
RPS8 ribosomal protein S8 -0.0237884
S100A9 S100 calcium binding protein A9 -0.0237687
EIF1 eukaryotic translation initiation factor 1 -0.0232114
RPS23 ribosomal protein S23 -0.0212313
CCND1 cyclin D1 -0.0206406
RPL36A ribosomal protein L36a -0.0205647
RPL36 ribosomal protein L36 -0.0202217
RPL38 ribosomal protein L38 -0.0200022
RPL11 ribosomal protein L11 -0.0197722
RPL23 ribosomal protein L23 -0.0193988
ACTG1 actin gamma 1 -0.019377
RPS17 ribosomal protein S17 -0.0185229
IFI16 interferon, gamma-inducible protein 16 -0.0184403
AKAP9 A kinase (PRKA) anchor protein 9 -0.018313
RPS27A ribosomal protein S27a -0.0181639
RPS14 ribosomal protein S14 -0.0181167
RPS11 ribosomal protein S11 -0.0180714
IFITM3 interferon induced transmembrane protein 3 -0.0176273
RPS12 ribosomal protein S12 -0.0173455
RPL27 ribosomal protein L27 -0.0171143
S100A10 S100 calcium binding protein A10 -0.0164202
FTH1 ferritin, heavy polypeptide 1 -0.0163793
RPL12 ribosomal protein L12 -0.0163187
S100A6 S100 calcium binding protein A6 -0.0163012
HMGA1 high mobility group AT-hook 1 -0.0162107
ENO2 enolase 2 (gamma, neuronal) -0.0158304
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0157082
CDK6 cyclin-dependent kinase 6 -0.0155724
RPS29 ribosomal protein S29 -0.015393
RPS25 ribosomal protein S25 -0.0151725
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0150873
CTSD cathepsin D -0.0144939
RPL26 ribosomal protein L26 -0.014452
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0140264
VDAC1 voltage-dependent anion channel 1 -0.0139107
RPL9 ribosomal protein L9 -0.0137653
HLA-A major histocompatibility complex, class I, A -0.0137437
RPS19 ribosomal protein S19 -0.0136996
RPS24 ribosomal protein S24 -0.0135383
RPS15 ribosomal protein S15 -0.0134053
RPS10 ribosomal protein S10 -0.0133344
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0133226
KLHL24 kelch-like family member 24 -0.0132985
RPLP0 ribosomal protein, large, P0 -0.0130427
PMP22 peripheral myelin protein 22 -0.0129579
TPI1 triosephosphate isomerase 1 -0.0129517
RPL35 ribosomal protein L35 -0.0126825
HDAC9 histone deacetylase 9 -0.0126746
RPL37 ribosomal protein L37 -0.0126508
MT1X metallothionein 1X -0.0126063
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0124823
SQSTM1 sequestosome 1 -0.0123177
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0122941
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0122745
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.0122738
HSPB1 heat shock 27kDa protein 1 -0.0121954
TNNC1 troponin C type 1 (slow) -0.0121155
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0120398
RPL8 ribosomal protein L8 -0.012023
APOD apolipoprotein D -0.0119981
ZBTB20 zinc finger and BTB domain containing 20 -0.0119774
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0119767
TAGLN2 transgelin 2 -0.0119537
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0118359
PFN1 profilin 1 -0.0118064
IFIH1 interferon induced with helicase C domain 1 -0.0115185
SP100 SP100 nuclear antigen -0.0115072
RPS27 ribosomal protein S27 -0.011396
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.0111585
TUBB tubulin, beta class I -0.0110971
OAZ1 ornithine decarboxylase antizyme 1 -0.0110409
CBX3 chromobox homolog 3 -0.0110282
RPL22L1 ribosomal protein L22-like 1 -0.0110181