c-Kit-IN-1_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANK2 ankyrin 2, neuronal 0.143282
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0938031
GPHN gephyrin 0.0908515
PDE4B phosphodiesterase 4B, cAMP-specific 0.0778824
PRELID2 PRELI domain containing 2 0.0718684
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0624864
HDAC9 histone deacetylase 9 0.0608909
EEF2 eukaryotic translation elongation factor 2 0.0594252
SMYD3 SET and MYND domain containing 3 0.0576576
NUP58 nucleoporin 58 0.0568567
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0548163
PTPRG protein tyrosine phosphatase, receptor type, G 0.0540254
ZFAND3 zinc finger, AN1-type domain 3 0.0532267
DOCK3 dedicator of cytokinesis 3 0.0517417
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0500467
GARS1 glycyl-tRNA synthetase 1 0.0500105
SRRM2 serine/arginine repetitive matrix 2 0.0498061
PCBP2 poly(rC) binding protein 2 0.0481292
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045813
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0451148
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0441968
NBAS neuroblastoma amplified sequence 0.0429918
SESN2 sestrin 2 0.0426116
PSAT1 phosphoserine aminotransferase 1 0.0400744
COG5 component of oligomeric golgi complex 5 0.039436
FNIP1 folliculin interacting protein 1 0.0377292
FNDC3B fibronectin type III domain containing 3B 0.0372811
TRIO trio Rho guanine nucleotide exchange factor 0.0372596
BRD2 bromodomain containing 2 0.0371059
SFPQ splicing factor proline/glutamine-rich 0.0365683
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0360079
APP amyloid beta (A4) precursor protein 0.0353342
RABGAP1L RAB GTPase activating protein 1-like 0.0353306
USP47 ubiquitin specific peptidase 47 0.0349615
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0348714
RPL3 ribosomal protein L3 0.0348564
DSCAM Down syndrome cell adhesion molecule 0.03422
GMDS GDP-mannose 4,6-dehydratase 0.0332283
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0330401
HOOK2 hook microtubule-tethering protein 2 0.0330153
GSE1 Gse1 coiled-coil protein 0.032881
ATP11A ATPase, class VI, type 11A 0.0327297
SOX6 SRY (sex determining region Y)-box 6 0.0324461
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0324316
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0321781
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0320887
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0320778
PUM3 pumilio RNA binding family member 3 0.0319291
MKI67 marker of proliferation Ki-67 0.0317876
DIAPH3 diaphanous-related formin 3 0.0317269
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0314796
LGALS12 lectin, galactoside-binding, soluble, 12 0.0314273
INTS6 integrator complex subunit 6 0.0311357
WDR43 WD repeat domain 43 0.0307897
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0305332
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0298647
TNPO1 transportin 1 0.0297307
RPTOR regulatory associated protein of MTOR, complex 1 0.0295139
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0292622
SRPK2 SRSF protein kinase 2 0.0289238
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0285895
PDE4D phosphodiesterase 4D, cAMP-specific 0.0285641
JMJD1C jumonji domain containing 1C 0.028544
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0284461
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0284364
AHCTF1 AT hook containing transcription factor 1 0.0280255
KMT2C lysine (K)-specific methyltransferase 2C 0.0279756
MACROD2 MACRO domain containing 2 0.0277236
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0276807
TTC28 tetratricopeptide repeat domain 28 0.027565
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0273516
MED12L mediator complex subunit 12-like 0.0273133
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0271887
MARS1 methionyl-tRNA synthetase 1 0.0271495
FAF1 Fas (TNFRSF6) associated factor 1 0.0270519
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0269531
CHD7 chromodomain helicase DNA binding protein 7 0.0268554
TARS1 threonyl-tRNA synthetase 1 0.0268355
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0265337
BIRC6 baculoviral IAP repeat containing 6 0.026502
MIPOL1 mirror-image polydactyly 1 0.0263911
HSPA8 heat shock 70kDa protein 8 0.0263293
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0262242
MEMO1 mediator of cell motility 1 0.0258993
SEC31A SEC31 homolog A (S. cerevisiae) 0.0257903
RBM26 RNA binding motif protein 26 0.0251624
INO80 INO80 complex subunit 0.0251155
PTEN phosphatase and tensin homolog 0.0251108
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.0248773
DDIT4 DNA-damage-inducible transcript 4 0.0248532
TRIM44 tripartite motif containing 44 0.0247138
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0246868
PTK2 protein tyrosine kinase 2 0.0246326
PMM2 phosphomannomutase 2 0.0245991
GLS2 glutaminase 2 (liver, mitochondrial) 0.0244508
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0241537
CCNH cyclin H 0.0241045
ZNF638 zinc finger protein 638 0.0240091
SND1 staphylococcal nuclease and tudor domain containing 1 0.0239828
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0239601

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.31021
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212448
VCL vinculin -0.171696
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.155599
TMSB4X thymosin beta 4, X-linked -0.144589
TPT1 tumor protein, translationally-controlled 1 -0.113098
AHNAK AHNAK nucleoprotein -0.103978
RPS6 ribosomal protein S6 -0.0966818
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0875358
TJP1 tight junction protein 1 -0.0820749
S100A6 S100 calcium binding protein A6 -0.079358
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0741917
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0732331
ACTG1 actin gamma 1 -0.0722053
PKM pyruvate kinase, muscle -0.0697768
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0660954
EGFR epidermal growth factor receptor -0.0659181
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0656684
RPS8 ribosomal protein S8 -0.0646944
ZBTB20 zinc finger and BTB domain containing 20 -0.0623328
SLC38A2 solute carrier family 38, member 2 -0.0609271
ADAM10 ADAM metallopeptidase domain 10 -0.0604769
RPL34 ribosomal protein L34 -0.0546317
FLNB filamin B, beta -0.0542318
RPL35A ribosomal protein L35a -0.0534425
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0533246
EVI5 ecotropic viral integration site 5 -0.0531864
RPL26 ribosomal protein L26 -0.0519431
RPL13A ribosomal protein L13a -0.0505711
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0472363
S100A4 S100 calcium binding protein A4 -0.0466
FOXP1 forkhead box P1 -0.0465142
RPL11 ribosomal protein L11 -0.0457661
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0456411
TGFBR3 transforming growth factor, beta receptor III -0.0453327
GNAS GNAS complex locus -0.0446087
RPS27A ribosomal protein S27a -0.0439869
NBEA neurobeachin -0.0418844
RPLP1 ribosomal protein, large, P1 -0.0414297
RPL12 ribosomal protein L12 -0.0403249
RPLP0 ribosomal protein, large, P0 -0.0400135
NAP1L1 nucleosome assembly protein 1-like 1 -0.0398961
WSB1 WD repeat and SOCS box containing 1 -0.0388321
MYL12B myosin, light chain 12B, regulatory -0.0381723
RPS23 ribosomal protein S23 -0.0381528
NPAS2 neuronal PAS domain protein 2 -0.0378631
RB1CC1 RB1-inducible coiled-coil 1 -0.0373843
SMNDC1 survival motor neuron domain containing 1 -0.0372833
PHF3 PHD finger protein 3 -0.0370862
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0357172
ARL4C ADP-ribosylation factor-like 4C -0.0356222
CCND1 cyclin D1 -0.0353116
RPLP2 ribosomal protein, large, P2 -0.0349523
SMC3 structural maintenance of chromosomes 3 -0.0346135
RAD21 RAD21 homolog (S. pombe) -0.0339709
RPS25 ribosomal protein S25 -0.0336022
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0333457
RPL31 ribosomal protein L31 -0.0331169
S100A10 S100 calcium binding protein A10 -0.0323482
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.032237
MXI1 MAX interactor 1, dimerization protein -0.0320325
DPYD dihydropyrimidine dehydrogenase -0.031698
OGA O-GlcNAcase -0.0316153
NEBL nebulette -0.0315906
NCEH1 neutral cholesterol ester hydrolase 1 -0.0314735
PNISR PNN-interacting serine/arginine-rich protein -0.0313405
ZEB1 zinc finger E-box binding homeobox 1 -0.0312379
RPL36 ribosomal protein L36 -0.0312242
ZNF217 zinc finger protein 217 -0.0310705
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0309096
TM4SF1 transmembrane 4 L six family member 1 -0.0307139
TXNIP thioredoxin interacting protein -0.0305395
NT5C2 5'-nucleotidase, cytosolic II -0.0300416
NEK7 NIMA-related kinase 7 -0.0299996
RPS24 ribosomal protein S24 -0.0298841
ZMYND8 zinc finger, MYND-type containing 8 -0.0297824
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0295847
B2M beta-2-microglobulin -0.0292536
TNRC6B trinucleotide repeat containing 6B -0.029234
BBX bobby sox homolog (Drosophila) -0.0288497
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0287314
RPS13 ribosomal protein S13 -0.0286183
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0285453
RPS3 ribosomal protein S3 -0.0283604
HSPB1 heat shock 27kDa protein 1 -0.028208
PYGB phosphorylase, glycogen; brain -0.0278866
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0277677
RPS11 ribosomal protein S11 -0.0274337
CD47 CD47 molecule -0.0272466
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0269001
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0265035
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0264093
RPL19 ribosomal protein L19 -0.0263886
RRBP1 ribosome binding protein 1 -0.0262736
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0262179
LOC112694756 uncharaterized LOC112694756 -0.0261927
RPL9 ribosomal protein L9 -0.0260577
RHOA ras homolog family member A -0.0256025
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0249028
RSL1D1 ribosomal L1 domain containing 1 -0.0248845