c-Kit-IN-1_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.169664
VCAN versican 0.169056
SOD2 superoxide dismutase 2, mitochondrial 0.145583
NAMPT nicotinamide phosphoribosyltransferase 0.139389
FN1 fibronectin 1 0.12372
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.116056
UBA6 ubiquitin-like modifier activating enzyme 6 0.0982323
TRIO trio Rho guanine nucleotide exchange factor 0.0966535
COL6A3 collagen, type VI, alpha 3 0.0954181
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0932216
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.085276
EEF2 eukaryotic translation elongation factor 2 0.0840581
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0835799
ZFAND3 zinc finger, AN1-type domain 3 0.0767839
SFTPA2 surfactant protein A2 0.0758697
CADM1 cell adhesion molecule 1 0.0729296
SMYD3 SET and MYND domain containing 3 0.072127
GARS1 glycyl-tRNA synthetase 1 0.0686229
NAV2 neuron navigator 2 0.0683986
DST dystonin 0.066163
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0660413
FRMD5 FERM domain containing 5 0.0645037
TSC22D2 TSC22 domain family, member 2 0.0636729
APP amyloid beta (A4) precursor protein 0.062678
ZNF292 zinc finger protein 292 0.0622781
USP9X ubiquitin specific peptidase 9, X-linked 0.0620007
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0602494
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0588694
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0572491
GPC6 glypican 6 0.0571524
IGF2R insulin-like growth factor 2 receptor 0.0568258
FOXP1 forkhead box P1 0.0566069
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0556899
ELL2 elongation factor, RNA polymerase II, 2 0.0554385
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.055153
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0546586
PGK1 phosphoglycerate kinase 1 0.0538455
CD109 CD109 molecule 0.0529289
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0523536
GOLGA4 golgin A4 0.0507636
FNIP1 folliculin interacting protein 1 0.0505967
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0497214
WDFY1 WD repeat and FYVE domain containing 1 0.0496009
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0493339
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0473818
ATP13A3 ATPase type 13A3 0.046813
AFF4 AF4/FMR2 family, member 4 0.0454006
TBC1D19 TBC1 domain family, member 19 0.0451487
FNDC3B fibronectin type III domain containing 3B 0.0435374
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0428997
JMJD1C jumonji domain containing 1C 0.0428473
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.042748
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0426144
IPO7 importin 7 0.042275
RTN4 reticulon 4 0.0416676
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0405425
ARL8B ADP-ribosylation factor-like 8B 0.0400059
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0389558
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0386898
ATXN1 ataxin 1 0.0384364
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0382781
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0381985
PPARD peroxisome proliferator-activated receptor delta 0.0378918
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.037596
PRRC2C proline-rich coiled-coil 2C 0.037424
SLC39A11 solute carrier family 39, member 11 0.0373772
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0371158
RBM39 RNA binding motif protein 39 0.0369826
HELZ helicase with zinc finger 0.0369046
CDK17 cyclin-dependent kinase 17 0.0365588
SPAG9 sperm associated antigen 9 0.0361441
LAMP2 lysosomal-associated membrane protein 2 0.036102
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0359874
HOOK2 hook microtubule-tethering protein 2 0.0354938
ANXA1 annexin A1 0.0353073
NUP58 nucleoporin 58 0.034694
ARRDC3 arrestin domain containing 3 0.03413
IARS1 isoleucyl-tRNA synthetase 1 0.0339063
RYBP RING1 and YY1 binding protein 0.0336151
METTL15 methyltransferase like 15 0.0335185
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0334568
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0333976
BACE2 beta-site APP-cleaving enzyme 2 0.0332723
MKI67 marker of proliferation Ki-67 0.032965
PRELID2 PRELI domain containing 2 0.0328484
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0325919
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0325365
OGA O-GlcNAcase 0.0324345
ANO6 anoctamin 6 0.0319241
PCBP2 poly(rC) binding protein 2 0.0317949
RUNX1 runt-related transcription factor 1 0.0317506
CCNL1 cyclin L1 0.0316353
USP37 ubiquitin specific peptidase 37 0.031275
ZNF207 zinc finger protein 207 0.0312652
MATR3 matrin 3 0.0306909
CEP250 centrosomal protein 250kDa 0.030677
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0299672
NDRG1 N-myc downstream regulated 1 0.0297967
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0288326
ICAM1 intercellular adhesion molecule 1 0.0288143

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.218286
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123451
FRMD4A FERM domain containing 4A -0.111409
TPT1 tumor protein, translationally-controlled 1 -0.093301
HMGA2 high mobility group AT-hook 2 -0.0858352
AKAP12 A kinase (PRKA) anchor protein 12 -0.084047
GLIS3 GLIS family zinc finger 3 -0.08094
RPS6 ribosomal protein S6 -0.0738399
HLA-B major histocompatibility complex, class I, B -0.0730536
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0705818
FTL ferritin, light polypeptide -0.0691784
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0676408
FTH1 ferritin, heavy polypeptide 1 -0.0624302
TMSB10 thymosin beta 10 -0.0600396
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0588726
KYNU kynureninase -0.0585107
RPS8 ribosomal protein S8 -0.0575238
MT2A metallothionein 2A -0.0558178
VCL vinculin -0.0551096
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0549141
IER3 immediate early response 3 -0.0534905
ZMYND8 zinc finger, MYND-type containing 8 -0.0528171
RPL37A ribosomal protein L37a -0.052712
CD44 CD44 molecule (Indian blood group) -0.050159
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0498212
HLA-A major histocompatibility complex, class I, A -0.0495811
INTS6 integrator complex subunit 6 -0.0463227
CDH13 cadherin 13 -0.0458449
ACTG1 actin gamma 1 -0.043971
RPLP2 ribosomal protein, large, P2 -0.0425977
RPL35A ribosomal protein L35a -0.0418441
BTG1 B-cell translocation gene 1, anti-proliferative -0.0416975
RPS23 ribosomal protein S23 -0.0412656
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0409305
SLC38A2 solute carrier family 38, member 2 -0.0400502
AHNAK AHNAK nucleoprotein -0.0379278
SQSTM1 sequestosome 1 -0.0374886
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0373899
EGFR epidermal growth factor receptor -0.0370646
RPL26 ribosomal protein L26 -0.0367673
RPL31 ribosomal protein L31 -0.0367118
BICC1 BicC family RNA binding protein 1 -0.0360284
RPL9 ribosomal protein L9 -0.0356949
EXT1 exostosin glycosyltransferase 1 -0.0356909
RPLP1 ribosomal protein, large, P1 -0.0354174
RPS12 ribosomal protein S12 -0.0352541
ZBTB20 zinc finger and BTB domain containing 20 -0.0350806
RPS24 ribosomal protein S24 -0.0342376
PTMA prothymosin, alpha -0.0341653
FBXO32 F-box protein 32 -0.0340584
RPS10 ribosomal protein S10 -0.0335097
EIF1 eukaryotic translation initiation factor 1 -0.0323698
KLHL24 kelch-like family member 24 -0.0318268
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.031571
RPS27A ribosomal protein S27a -0.0315398
RPS3 ribosomal protein S3 -0.0314293
RPS13 ribosomal protein S13 -0.0311096
STC1 stanniocalcin 1 -0.030486
EFNA5 ephrin-A5 -0.0301278
CTSD cathepsin D -0.0296929
FAM20C family with sequence similarity 20, member C -0.0295558
RPL12 ribosomal protein L12 -0.0294324
RPS17 ribosomal protein S17 -0.0293476
RPL11 ribosomal protein L11 -0.028814
RPL19 ribosomal protein L19 -0.0287495
RAD51B RAD51 paralog B -0.0286206
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0282381
RAI14 retinoic acid induced 14 -0.0279374
TNRC6B trinucleotide repeat containing 6B -0.0278624
TMEM132D transmembrane protein 132D -0.0271981
AFF3 AF4/FMR2 family, member 3 -0.0271866
NABP1 nucleic acid binding protein 1 -0.0271492
RPS29 ribosomal protein S29 -0.0271206
GNAS GNAS complex locus -0.0266408
RPLP0 ribosomal protein, large, P0 -0.026223
PHF3 PHD finger protein 3 -0.0261993
TPM1 tropomyosin 1 (alpha) -0.0260928
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0257381
RPS19 ribosomal protein S19 -0.0256292
IGFBP3 insulin-like growth factor binding protein 3 -0.0255444
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0252332
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.025211
RPS14 ribosomal protein S14 -0.0251593
SNX14 sorting nexin 14 -0.0247959
NAV1 neuron navigator 1 -0.0247794
TPM4 tropomyosin 4 -0.0246897
PALLD palladin, cytoskeletal associated protein -0.0243906
CLMP CXADR-like membrane protein -0.0242512
SAMD3 sterile alpha motif domain containing 3 -0.0241575
RPL5 ribosomal protein L5 -0.0239252
EGR1 early growth response 1 -0.0236696
B2M beta-2-microglobulin -0.0235398
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0234709
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0234493
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0233576
CUX1 cut-like homeobox 1 -0.0233344
NT5E 5'-nucleotidase, ecto (CD73) -0.0232361
RACK1 receptor for activated C kinase 1 -0.0232072
SFRP1 secreted frizzled-related protein 1 -0.0230297
PTPRK protein tyrosine phosphatase, receptor type, K -0.0228523