c-Kit-IN-1_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.232587
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0760469
STC2 stanniocalcin 2 0.071835
NRG1 neuregulin 1 0.0717266
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0714712
TRIO trio Rho guanine nucleotide exchange factor 0.0630308
GRB10 growth factor receptor-bound protein 10 0.0568251
FAT1 FAT atypical cadherin 1 0.0536428
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0495122
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0466212
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0412406
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0392899
HMGA2 high mobility group AT-hook 2 0.0390481
RASAL2 RAS protein activator like 2 0.0388051
MYH9 myosin, heavy chain 9, non-muscle 0.0372142
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0363509
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0348484
FN1 fibronectin 1 0.0348337
FLNA filamin A, alpha 0.0346029
GPC6 glypican 6 0.0322495
MAP1B microtubule-associated protein 1B 0.032055
SAMD4A sterile alpha motif domain containing 4A 0.0313291
GPATCH2L G patch domain containing 2-like 0.0309393
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0305339
AEBP2 AE binding protein 2 0.0297612
SLC35F3 solute carrier family 35, member F3 0.0297316
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0296854
ZSWIM6 zinc finger, SWIM-type containing 6 0.0296105
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 0.029542
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0294843
GPHN gephyrin 0.0293057
DST dystonin 0.0292326
ASPH aspartate beta-hydroxylase 0.0290797
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0279248
PLEC plectin 0.0259051
TPM3 tropomyosin 3 0.0258978
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0256177
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0256174
CREB5 cAMP responsive element binding protein 5 0.025602
SCFD2 sec1 family domain containing 2 0.0255414
LIMCH1 LIM and calponin homology domains 1 0.0254424
TP53BP2 tumor protein p53 binding protein 2 0.02517
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0250525
INTS6 integrator complex subunit 6 0.024703
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0244754
HSPA8 heat shock 70kDa protein 8 0.0244167
MCL1 myeloid cell leukemia 1 0.024291
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0242749
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0241526
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0232233
TARS1 threonyl-tRNA synthetase 1 0.0231203
FNIP1 folliculin interacting protein 1 0.0228128
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0226859
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0226175
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0225124
SYT1 synaptotagmin I 0.0224428
CTBP2 C-terminal binding protein 2 0.0221585
FRMD5 FERM domain containing 5 0.0221099
GMDS GDP-mannose 4,6-dehydratase 0.0220567
SND1 staphylococcal nuclease and tudor domain containing 1 0.021746
ERRFI1 ERBB receptor feedback inhibitor 1 0.0211257
CD109 CD109 molecule 0.0210717
ATP13A3 ATPase type 13A3 0.0208055
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0204761
TXNRD1 thioredoxin reductase 1 0.0203057
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.020189
NAV3 neuron navigator 3 0.0201787
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0201346
VCL vinculin 0.019961
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0198447
FMNL2 formin-like 2 0.0198318
CORO1C coronin, actin binding protein, 1C 0.0195834
HSPH1 heat shock 105kDa/110kDa protein 1 0.0194748
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0193156
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0190033
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0189989
GARS1 glycyl-tRNA synthetase 1 0.0186799
MACF1 microtubule-actin crosslinking factor 1 0.0186644
PDLIM5 PDZ and LIM domain 5 0.018651
RASEF RAS and EF-hand domain containing 0.0185887
SRRM2 serine/arginine repetitive matrix 2 0.018466
LRMDA leucine rich melanocyte differentiation associated 0.018368
RND3 Rho family GTPase 3 0.0182693
GPR39 G protein-coupled receptor 39 0.0182278
AHNAK AHNAK nucleoprotein 0.0181549
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0179303
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.017682
TTC28 tetratricopeptide repeat domain 28 0.017629
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0173501
WDR43 WD repeat domain 43 0.0173067
CADM1 cell adhesion molecule 1 0.0172422
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0172247
EFNA5 ephrin-A5 0.0172132
GLS2 glutaminase 2 (liver, mitochondrial) 0.0171076
SFTPA2 surfactant protein A2 0.0170257
HOMER1 homer scaffolding protein 1 0.0169273
ADGRA3 adhesion G protein-coupled receptor A3 0.0169162
NBAS neuroblastoma amplified sequence 0.0167898
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.01677
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0166884

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.517941
MT2A metallothionein 2A -0.164635
NAMPT nicotinamide phosphoribosyltransferase -0.123508
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.119157
PTMA prothymosin, alpha -0.0978715
FTL ferritin, light polypeptide -0.0922118
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0910142
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0791415
B2M beta-2-microglobulin -0.0735787
RPS6 ribosomal protein S6 -0.0699066
VIM vimentin -0.0672836
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0641279
AHR aryl hydrocarbon receptor -0.0586503
TMSB10 thymosin beta 10 -0.0555443
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0548097
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0542534
HLA-B major histocompatibility complex, class I, B -0.0522218
NDRG1 N-myc downstream regulated 1 -0.0519886
TXNIP thioredoxin interacting protein -0.0511421
RPL26 ribosomal protein L26 -0.0477236
NEK7 NIMA-related kinase 7 -0.0475655
ITGA1 integrin, alpha 1 -0.0470722
S100A6 S100 calcium binding protein A6 -0.0460789
TPT1 tumor protein, translationally-controlled 1 -0.0451304
RPLP1 ribosomal protein, large, P1 -0.0450699
FNBP1 formin binding protein 1 -0.0447257
OGA O-GlcNAcase -0.042441
RPS19 ribosomal protein S19 -0.0409905
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0408478
RPS12 ribosomal protein S12 -0.0400728
TMEM156 transmembrane protein 156 -0.0392645
RPS27 ribosomal protein S27 -0.0390492
RPS8 ribosomal protein S8 -0.0390005
RPS29 ribosomal protein S29 -0.0379312
GCC2 GRIP and coiled-coil domain containing 2 -0.0378165
SQSTM1 sequestosome 1 -0.0377102
IFI27 interferon, alpha-inducible protein 27 -0.0376511
RPL37A ribosomal protein L37a -0.0369042
RB1CC1 RB1-inducible coiled-coil 1 -0.0364048
RPL9 ribosomal protein L9 -0.0363322
MIS18BP1 MIS18 binding protein 1 -0.0359307
CENPF centromere protein F, 350/400kDa -0.0358993
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0353168
RPS27A ribosomal protein S27a -0.0344218
RPL11 ribosomal protein L11 -0.0342747
RBM39 RNA binding motif protein 39 -0.0339988
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0339912
PELO pelota homolog (Drosophila) -0.0339452
KMT2E lysine (K)-specific methyltransferase 2E -0.0338469
RPL31 ribosomal protein L31 -0.033433
AKAP9 A kinase (PRKA) anchor protein 9 -0.0332408
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0330623
TMSB4X thymosin beta 4, X-linked -0.032855
RPL35A ribosomal protein L35a -0.0324929
RPS21 ribosomal protein S21 -0.0324748
RPL12 ribosomal protein L12 -0.032405
RPS23 ribosomal protein S23 -0.0321352
SMOX spermine oxidase -0.0321177
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0313019
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0310734
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0310363
RPS3 ribosomal protein S3 -0.0308523
TPR translocated promoter region, nuclear basket protein -0.0308438
RPL28 ribosomal protein L28 -0.0302502
EIF1 eukaryotic translation initiation factor 1 -0.0301442
RPS20 ribosomal protein S20 -0.0301236
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0300957
PNISR PNN-interacting serine/arginine-rich protein -0.0300703
NAP1L1 nucleosome assembly protein 1-like 1 -0.0293337
RPL19 ribosomal protein L19 -0.0290442
S100A10 S100 calcium binding protein A10 -0.0286433
CREBRF CREB3 regulatory factor -0.0284964
UGCG UDP-glucose ceramide glucosyltransferase -0.0281997
ZNF292 zinc finger protein 292 -0.0281945
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0281535
PKM pyruvate kinase, muscle -0.0280708
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0279033
TPI1 triosephosphate isomerase 1 -0.0278296
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0277346
CD44 CD44 molecule (Indian blood group) -0.0276835
RPL38 ribosomal protein L38 -0.0276803
RPS5 ribosomal protein S5 -0.0275322
ELL2 elongation factor, RNA polymerase II, 2 -0.0272167
RPL36 ribosomal protein L36 -0.0270613
RNF145 ring finger protein 145 -0.0270436
RPL34 ribosomal protein L34 -0.0269923
RPS25 ribosomal protein S25 -0.0269717
RPS16 ribosomal protein S16 -0.0269156
RPS11 ribosomal protein S11 -0.0268775
RPS2 ribosomal protein S2 -0.0268365
FBXO32 F-box protein 32 -0.0266693
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0264658
RPLP2 ribosomal protein, large, P2 -0.0262618
HBP1 HMG-box transcription factor 1 -0.0262123
SEPTIN7 septin 7 -0.0261778
RPL8 ribosomal protein L8 -0.0261584
S100A9 S100 calcium binding protein A9 -0.0261442
RAB2A RAB2A, member RAS oncogene family -0.0261198
ETV1 ets variant 1 -0.0261188
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0260264