c-Kit-IN-1_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description c-Kit-IN-1 perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the c-Kit-IN-1_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0875284
GARS1 glycyl-tRNA synthetase 1 0.0696945
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0570511
ZFAND3 zinc finger, AN1-type domain 3 0.056672
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0532545
CANX calnexin 0.0520278
SND1 staphylococcal nuclease and tudor domain containing 1 0.0518336
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0511479
EEF2 eukaryotic translation elongation factor 2 0.0507057
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0484132
WDR43 WD repeat domain 43 0.0473446
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0466706
GMDS GDP-mannose 4,6-dehydratase 0.0459377
NAMPT nicotinamide phosphoribosyltransferase 0.0456485
HSPA8 heat shock 70kDa protein 8 0.044804
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0445981
OLA1 Obg-like ATPase 1 0.0438439
FRMD5 FERM domain containing 5 0.0436239
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0433774
ZNRF3 zinc and ring finger 3 0.0430881
PTK2 protein tyrosine kinase 2 0.042826
ANKRD11 ankyrin repeat domain 11 0.0427618
GOLGA4 golgin A4 0.0424214
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0420334
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0412153
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0395464
TFRC transferrin receptor 0.0392155
EIF4A2 eukaryotic translation initiation factor 4A2 0.0384807
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0363861
TARS1 threonyl-tRNA synthetase 1 0.0356745
NCKAP1 NCK-associated protein 1 0.0354767
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0353457
FAR1 fatty acyl CoA reductase 1 0.0347185
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0341025
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.033544
PLEC plectin 0.0329753
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0325594
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0315735
TSC22D2 TSC22 domain family, member 2 0.031158
UPP1 uridine phosphorylase 1 0.0303117
MEMO1 mediator of cell motility 1 0.0299583
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0298911
GRB10 growth factor receptor-bound protein 10 0.0298856
IPO7 importin 7 0.0298733
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0298544
PUM3 pumilio RNA binding family member 3 0.0297137
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0294405
PDIA6 protein disulfide isomerase family A, member 6 0.0291126
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0289634
IARS1 isoleucyl-tRNA synthetase 1 0.0286202
FMNL2 formin-like 2 0.0285361
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0284637
APP amyloid beta (A4) precursor protein 0.0283168
MATR3 matrin 3 0.0282041
FLNA filamin A, alpha 0.0277844
EWSR1 EWS RNA-binding protein 1 0.0276362
HKDC1 hexokinase domain containing 1 0.0275986
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0270628
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.02692
TNNC1 troponin C type 1 (slow) 0.0266934
NUP58 nucleoporin 58 0.0261087
PRRC2C proline-rich coiled-coil 2C 0.0260669
SET SET nuclear proto-oncogene 0.0258727
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0255224
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0255181
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.0252267
PDIA3 protein disulfide isomerase family A, member 3 0.0252048
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0250818
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0249097
FNDC3B fibronectin type III domain containing 3B 0.0248846
GPHN gephyrin 0.0247731
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0246947
COG5 component of oligomeric golgi complex 5 0.0246605
TOP1 topoisomerase (DNA) I 0.0242799
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0242283
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0240303
BHLHE40 basic helix-loop-helix family, member e40 0.0240079
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0237795
ARL8B ADP-ribosylation factor-like 8B 0.0235318
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0234363
MYO10 myosin X 0.023423
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0234208
MYH9 myosin, heavy chain 9, non-muscle 0.0233087
PSAT1 phosphoserine aminotransferase 1 0.0230541
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0230359
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0228397
NBAS neuroblastoma amplified sequence 0.0227307
TXNRD1 thioredoxin reductase 1 0.0227298
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0224132
ATP13A3 ATPase type 13A3 0.0222923
XRN2 5'-3' exoribonuclease 2 0.0222332
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0221607
CAMKMT calmodulin-lysine N-methyltransferase 0.0219163
SIK3 SIK family kinase 3 0.0216936
GLS2 glutaminase 2 (liver, mitochondrial) 0.0216454
MAP4 microtubule-associated protein 4 0.0216441
SPAG9 sperm associated antigen 9 0.0216313
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 0.0211508
ZNF841 zinc finger protein 841 0.0209004
CCNY cyclin Y 0.0208904

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.184913
TMSB10 thymosin beta 10 -0.168844
FTL ferritin, light polypeptide -0.165241
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120212
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.114255
MAML2 mastermind-like 2 (Drosophila) -0.091761
NCEH1 neutral cholesterol ester hydrolase 1 -0.0776573
BCL2L1 BCL2-like 1 -0.0762525
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.07619
ZBTB20 zinc finger and BTB domain containing 20 -0.0723052
B2M beta-2-microglobulin -0.0636887
LOC102724023 ES1 protein homolog, mitochondrial -0.0614812
MYOF myoferlin -0.060353
TPT1 tumor protein, translationally-controlled 1 -0.059624
EZR ezrin -0.0584675
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0569635
ZMYND8 zinc finger, MYND-type containing 8 -0.056067
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0553447
AKAP9 A kinase (PRKA) anchor protein 9 -0.0550901
RPL35A ribosomal protein L35a -0.0550438
EGR1 early growth response 1 -0.0534731
RPLP1 ribosomal protein, large, P1 -0.0530681
RPS21 ribosomal protein S21 -0.0503334
MACC1 metastasis associated in colon cancer 1 -0.0496656
CST3 cystatin C -0.04861
PERP PERP, TP53 apoptosis effector -0.0460821
IFITM1 interferon induced transmembrane protein 1 -0.0458798
RPLP2 ribosomal protein, large, P2 -0.0435083
GCC2 GRIP and coiled-coil domain containing 2 -0.0424488
RPL28 ribosomal protein L28 -0.0419935
MYO1E myosin IE -0.0418318
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0416812
NEBL nebulette -0.0413976
RPS6 ribosomal protein S6 -0.0383154
BBX bobby sox homolog (Drosophila) -0.0370758
RPS13 ribosomal protein S13 -0.03653
ERBIN erbb2 interacting protein -0.0359493
RPS19 ribosomal protein S19 -0.0352804
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0350064
EPCAM epithelial cell adhesion molecule -0.0347289
SDK1 sidekick cell adhesion molecule 1 -0.0347113
S100A6 S100 calcium binding protein A6 -0.0338839
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0338734
S100A10 S100 calcium binding protein A10 -0.0333528
NEK7 NIMA-related kinase 7 -0.0329759
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0327955
PLSCR1 phospholipid scramblase 1 -0.032618
SP100 SP100 nuclear antigen -0.0324402
VCL vinculin -0.0323548
SBF2 SET binding factor 2 -0.0322285
RSF1 remodeling and spacing factor 1 -0.0321075
SLC38A1 solute carrier family 38, member 1 -0.0320375
IFITM3 interferon induced transmembrane protein 3 -0.0318073
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0312749
TNRC6B trinucleotide repeat containing 6B -0.0312726
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0312343
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0308419
GSTP1 glutathione S-transferase pi 1 -0.0302537
CCND1 cyclin D1 -0.0301946
ETV6 ets variant 6 -0.0299506
MX2 MX dynamin-like GTPase 2 -0.0296387
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.029492
DEK DEK proto-oncogene -0.029407
ARHGAP42 Rho GTPase activating protein 42 -0.0293351
RPL12 ribosomal protein L12 -0.029205
OSBPL10 oxysterol binding protein-like 10 -0.0291922
H3-3B H3.3 histone B -0.0290657
KLHL24 kelch-like family member 24 -0.0286342
SOX4 SRY (sex determining region Y)-box 4 -0.0286277
STAT1 signal transducer and activator of transcription 1, 91kDa -0.028499
IFI6 interferon, alpha-inducible protein 6 -0.0284871
CLDN4 claudin 4 -0.0284191
TMEM123 transmembrane protein 123 -0.0283975
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0280326
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0280258
GNAS GNAS complex locus -0.0279069
ANKRD12 ankyrin repeat domain 12 -0.0276943
LMO7 LIM domain 7 -0.0276118
RPL31 ribosomal protein L31 -0.0274755
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0273866
EIF1 eukaryotic translation initiation factor 1 -0.027233
EDN1 endothelin 1 -0.0272326
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0268234
KRT18 keratin 18, type I -0.0263723
EXOC4 exocyst complex component 4 -0.0262672
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0262301
RPS11 ribosomal protein S11 -0.0261282
IER3 immediate early response 3 -0.026071
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0260286
KRT8 keratin 8, type II -0.0254982
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.025413
MYL12B myosin, light chain 12B, regulatory -0.0252919
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0252755
CENPF centromere protein F, 350/400kDa -0.0252005
BCAS3 breast carcinoma amplified sequence 3 -0.0251536
FBXL20 F-box and leucine-rich repeat protein 20 -0.0250501
RB1CC1 RB1-inducible coiled-coil 1 -0.0249714
TPM4 tropomyosin 4 -0.0249581
SERINC5 serine incorporator 5 -0.0247919
CBX3 chromobox homolog 3 -0.0247632